Category: methodological problems

Authors retract (and replace) cardiac rehab study in JAMA journal

jama-internal-medicine

Researchers have retracted and replaced a 2014 paper in JAMA Internal Medicine after realizing a number of errors had affected the findings.

The authors note the mistakes do not have a significant impact on the overall proportion of heart patients who participated in cardiac rehab. However, a number of findings were affected, such as the difference in participation in cardiac rehab defined by race, and how the overall participation has changed throughout the years.

Therefore, JAMA Internal Medicine has published a lengthy notice of retraction and replacement, which explains the errors made in the original paper, and updated the first paper with a new version of the study.

The retraction and replacement notice, issued this week, starts: Continue reading Authors retract (and replace) cardiac rehab study in JAMA journal

Costly genotyping mistake forces lab to pull 3rd paper

KPSB_11_09_COVER.inddA few months ago, an author alerted us to two retractions — including one in PNAS — after realizing his team had been using plants affected by inadvertent genotyping errors for an entire year. He initially told us these were the only two papers affected, but more recently reached out to say he had to pull a follow-up article, as well.

Recently, Steven C. Huber contacted us about the newest retraction, noting he was submitting a notice to the editor of Plant Signaling and Behavior:

Continue reading Costly genotyping mistake forces lab to pull 3rd paper

Child psychiatrist flagged for misconduct loses two more papers

Mani PavuluriA child psychiatrist has lost two papers after an institutional investigation concluded that she intentionally misrepresented children’s medication history in her research.

In November 2015, we reported on a retraction for Mani Pavuluri in the Journal of Psychiatry & Neuroscience following a probe at the University of Illinois at Chicago, her institution, which concluded that there was a “preponderance of evidence” that Pavuluri had committed misconduct. 

After an “unanticipated event” took place during a study, three studies by Pavuluri were halted and a letter was sent out to 350 research subjects, informing them of errors in the work. At the time, the Illinois spokesperson noted that Pavuluri — who, according to her LinkedIn page, is a Distinguished Fellow of the American Academy of Child and Adolescent Psychiatry — was also asked to retract two 2013 studies in the Journal of Affective Disorders. Those papers have now been retracted, noting that Pavuluri “intentionally and knowingly” misrepresented children’s medication history.

Here’s the retraction notice for “Deficits in emotion recognition in pediatric bipolar disorder: The mediating effects of irritability:” Continue reading Child psychiatrist flagged for misconduct loses two more papers

Oh, well — “love hormone” doesn’t reduce psychiatric symptoms, say researchers in request to retract

psychiatry-research

It turns out, snorting the so-called “love hormone” may not help reduce psychiatric symptoms such as depression and anxiety.

At least, that’s the conclusion the authors of a 2015 meta-analysis, which initially found intranasal doses of oxytocin could reduce psychiatric symptoms, have now reached. After a pair of graduate students pointed out flaws in the paper, the authors realized they’d made some significant errors, and oxytocin shows no more benefit than placebo.

First author Stefan Hofmann from Boston University in Massachusetts explains further in a lengthy letter he sent to Psychiatry Research, which he passed on to us: Continue reading Oh, well — “love hormone” doesn’t reduce psychiatric symptoms, say researchers in request to retract

Error in one line of code sinks cancer study

journl-of-clinical-oncologyAuthors of a 2016 cancer paper have retracted it after finding an error in one line of code in the program used to calculate some of the results.

Sarah Darby, last author of the now-retracted paper from the University of Oxford, UK, told Retraction Watch that the mistake was made by a doctoral student. When the error was realized, Darby said, she contacted the Journal of Clinical Oncology (JCO), explained the issue, and asked whether they would prefer a retraction or a correction. JCO wanted a retraction, and she complied.

The journal allowed the authors to publish a correspondence article outlining their new results.

Here’s the lengthy retraction notice, published online last month: Continue reading Error in one line of code sinks cancer study

Authors retract two papers on shock therapy, citing language barriers

the-journal-of-ectAn electroconvulsive therapy (ECT) journal has retracted two 2016 papers after uncovering problems in the data analyses, which the author says were due to language barriers.

Interestingly, two authors of the newly retracted papers — Yu-Tao Xiang from the University of Macau in China and Gabor Ungvari from the University of Western Australia — also recently co-authored another paper on an entirely different topic that has received a lengthy correction. That paper — on the use of organs from executed prisoners in China — raised controversy for allegedly reporting a “sanitized” account of the practice. The correction notice, in the Journal of Medical Ethics, was accompanied by a critics’ rebuttal to the paper.

According to Xiang, the newly retracted papers in The Journal of ECT — which examined the efficacy of ECT in treating schizophrenia — were pulled due to “genuine errors” resulting from differences in language. All the authors agree with the retraction, Xiang noted. 

Xiang told us: Continue reading Authors retract two papers on shock therapy, citing language barriers

How can we improve preclinical research? Advice from a diabetes researcher

Daniel Drucker
Daniel Drucker

By all accounts, science is facing a crisis: Too many preclinical studies aren’t reproducible, leading to wasted time and effort by researchers around the world. Today in Cell Metabolism, Daniel Drucker at the Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital in Toronto details numerous ways to make this early research more robust. His most important advice: more transparent reporting of all results (not just the positive findings), along with quantifying, reporting, tracking, and rewarding reproducibility, for both scientists and journals and universities/research institutes.

Retraction Watch: Which of your recommendations will researchers most object to, and why? Continue reading How can we improve preclinical research? Advice from a diabetes researcher

Author objects to retraction of heart study, implies industry played role

JACC

The Journal of the American College of Cardiology (JACC) has retracted a recently published paper that questioned the effectiveness of a treatment for irregular heartbeat, against the last author’s wishes. 

Andrea Natale, the study’s last and corresponding author and Executive Medical Director of Texas Cardiac Arrhythmia at Austin, took to social media today to express his frustration in the retraction of the July paper, which showed electrical rotors were less effective at fixing irregular heartbeat than other treatments. On Twitter, Natale implied industry played a role in its demise.

However, according to the retraction notice, the paper was felled by problems with randomization; Natale has admitted that some patients were removed from the analysis after one center included them incorrectly.

Here’s the retraction notice for “Impact of Rotor Ablation in Nonparoxysmal Atrial Fibrillation Patients Results From the Randomized OASIS Trial:” Continue reading Author objects to retraction of heart study, implies industry played role

Anesthesia journal pulls study lacking patient consent

Journal of AnesthesiaAn anesthesia journal has retracted a paper after an author admitted that the study did not obtain appropriate consent from patients receiving a neuromuscular block in muscles on the face and hands. 

The first author, Yuhji Saitoh, has the same name as a co-author of Yoshitaka Fujii, the all-time record holder with 183 retractions listed on our leaderboard. Thirty-six of those retracted papers include a co-author with the name of Yuhji Saitoh, but we were unable to confirm this is the same person listed on the newly retracted paper.  

Here’s the retraction notice, issued by the Journal of Anesthesia on August 11: Continue reading Anesthesia journal pulls study lacking patient consent

Collateral damage: Paper — and editorial, and author’s response — retracted in one fell swoop

euro jA journal has retracted the results of a clinical trial comparing strategies for bladder tumors after the authors mischaracterized the way patients were assigned to each procedure.

In addition, the journal European Urology has pulled a string of correspondence between author Harry Herr at Memorial Sloan Kettering Cancer Center and an outside expert, who had questioned aspects of the study totally unrelated to the methodology, such as its generalizability.

Here’s the retraction notice for ” Randomized Trial of Narrow-band Versus White-light Cystoscopy for Restaging (Second-look) Transurethral Resection of Bladder Tumors:”  Continue reading Collateral damage: Paper — and editorial, and author’s response — retracted in one fell swoop