There’s “no evidence” research was conducted at all in retracted cancer paper

cov200h (1)To one reader of a paper on a nerve cancer, the researchers, based at a hospital in China, seemed to have found a very large number of cases of a rare cancer to study. That observation triggered an investigation into the paper that led to its retraction — and the concern that the authors in the paper never did the research at all.

The authors say they recruited 156 patients who had a particular kind of cancer that affects the tissue around nerves, known as malignant peripheral nerve sheath tumors. For context on how rare that is: Other researchers found a mere 1,182 new cases over a nearly four-decade period in the U.S. The study, according to the methods section of the paper, was supposedly done with patients who had a specific type of the disease, and who were

consecutively recruited from Wuhan Union Hospital, Huazhong University of Science and Technology in Wuhan (Hubei, China) between July 2000 and November 2012

According to the retraction note for “Common genetic variants in the microRNA biogenesis pathway are associated with malignant peripheral nerve sheath tumor risk in a Chinese population,” the hospital where the work was done never treated all of those patients:

Continue reading There’s “no evidence” research was conducted at all in retracted cancer paper

Danish neuroscientist sentenced by court for lying about faked experiments

court caseIn a rare development, neuroscientist Milena Penkowa has been sentenced by a Danish court for faking data.

The ruling, from the Copenhagen City Court, resulted from Penkowa’s publication of her 2003 thesis describing experiments that she never carried out. The court “placed weight” on the fact that she didn’t just commit fraud, but “systematically supplied false information” to avoid being caught, according to the court’s notice.

The sentence is nine months of “conditional imprisonment,” according to our translation; The University Posta newspaper affiliated with the University of Copenhagen, calls it a “nine month suspended sentence with a two years probation.”

Here’s the full summary of the new ruling, from the Copenhagen City Court (translated from Danish by One Hour Translation):

Continue reading Danish neuroscientist sentenced by court for lying about faked experiments

4th ORI-flagged paper by Oregon student is retracted

home_cover (2)The last of four papers containing data falsified by University of Oregon neuroscience student David Anderson has been retracted.

When the Office of Research Integrity report flagging the papers came out in July, Anderson told us he “made an error in judgment,” and took “full responsibility” for the misconduct.

The newly retracted paper, “A common discrete resource for visual working memory and visual search,” published in Psychological Science, has been cited 28 times, according to Thomson Scientific’s Web of Knowledge. According to the abstract, it demonstrates a possible link between working memory and the ability to “rapidly identify targets hidden among distractors.”

But according to the retraction note, Anderson produced “results that conformed to predictions” by “removing outlier values and replacing outliers with mean values”  in some of the data.

Here’s the retraction note in full:

Continue reading 4th ORI-flagged paper by Oregon student is retracted

Mirror image in plant study flagged on PubPeer grows into retraction

djs_mpmi_28_9_cover-online.inddA 2010 paper on plant fungus has been retracted after a comment on PubPeer revealed that a study image had been flipped over and reused to represent two different treatments.

In May, a commenter pointed out the plants in Figure 2a of the paper in the journal Molecular Plant-Microbe Interactions “look remarkably similar.” A commenter writing under the name of corresponding author, Yukio Tosa at Kobe University in Japan, posted a response two days later agreeing with the assessment and stating that the paper should be retracted.

The notice reads: Continue reading Mirror image in plant study flagged on PubPeer grows into retraction

Science Signaling corrects data fudged by former UCSF student

afbb251f8bc8f71e26b313c77669d48fA paper containing data fudged by former University of California San Francisco grad student Peter Littlefield has been corrected. We knew that this was coming — last month, the Office of Research Integrity issued a report that Littlefield had admitted to misconduct, and agreed to a retraction or correction of the two affected papers.

Published in Science Signaling, “Structural analysis of the /HER3 heterodimer reveals the molecular basis for activating HER3 mutations” examined the structural details of a protein associated with cancer. It has been cited two times, according to Thomson Scientific’s Web of Knowledge.

According to the correction note, the concentration of a protein presented in one figure was “miscalculated;” in another figure, the error bars were “calculated incorrectly.”

A statement from the UCSF affirmed that principle investigator Natalie Jura has “not been implicated in any research misconduct finding,” and explains that Continue reading Science Signaling corrects data fudged by former UCSF student

“Fabricated results” retract JAMA clinical trial, plus a sub-analysis of the data

Screen Shot 2015-09-14 at 11.00.11 AMA JAMA clinical trial that suggested a blood pressure drug could help patients increase their physical fitness, and a sub-analysis of those data, have been retracted after “an admission of fabricated results” by the first author on both papers.

The three-year clinical trial was published in JAMA in 2013.  It was retracted this morning.

The trial found ramipril helped patients with artery disease walk longer and with less pain, according to the abstract:

Among patients with intermittent claudication, 24-week treatment with ramipril resulted in significant increases in pain-free and maximum treadmill walking times compared with placebo. This was associated with a significant increase in the physical functioning component of the SF-36 score.

The retraction note explains how the fabricated data came to light: 

Continue reading “Fabricated results” retract JAMA clinical trial, plus a sub-analysis of the data

CDC: Falsified data did not affect C. diff results

downloadDespite the fact that a former employee of the Oregon Health Authority falsified 56 case reports that were included in a report by the U.S. Centers for Disease Control and Prevention (CDC), a re-analysis has found that the results of the report remain valid.

The report included information about 10,342 cases of potentially deadly infections due to Clostridium difficile, so removing the cases affected by the misconduct — 57 in total — “did not” alter the results, according to an analysis published today by the CDC:

Continue reading CDC: Falsified data did not affect C. diff results

“Obviously stolen” figure squashes mosquito paper in author’s second retraction

jmr-cover2015The Journal of Mosquito Research has retracted a paper because it contains a figure that “was obviously stolen” from another paper.

The retracted paper’s first author Emtithal M. Abd El-Samiee is now up to two retractions, by our count. Last month, we reported on her fruit fly paper, felled by a faulty gene sequence. On the paper, she is listed as an entomologist at Cairo University.

The note tells us where the figure was stolen from:

Continue reading “Obviously stolen” figure squashes mosquito paper in author’s second retraction

Years after papers were withdrawn, JBC issues notices

Journal of Biological Chemistry.coverThe Journal of Biological Chemistry has posted withdrawal notices for six papers that had already been withdrawn, some more than a decade ago, in an effort to resolve “PubMed indexing problems.”

Each paper had been pulled by the author before it appeared in print, but still appeared online on the the journal’s website and in PubMed. 

By our count, the journal has posted six notices so far, and said we should expect to see more in the future.

Kaoru Sakabe the Manager of Publication Issues at the American Society for Biochemistry and Molecular Biology, which publishes JBC, provided a statement on the new withdrawal notices: Continue reading Years after papers were withdrawn, JBC issues notices

Retraction of grizzly bear-diabetes study follows departure of Amgen scientist for data manipulation

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The retracted paper made the cover of the August 2014 issue of the journal.

A study that looked to hibernating bears to understand the mechanisms behind diabetes has been retracted because an author based at the biotech company Amgen “manipulated specific experimental data” in two figures.

According to the The Wall Street JournalAmgen discovered the manipulation while reviewing the data following publication of the paper,”Grizzly bears exhibit augmented insulin sensitivity while obese prior to a reversible insulin resistance during hibernation.” Published in Cell Metabolism last year, the paper has been cited 8 times, according to Thomson Scientific’s Web of Knowledge.

A press release from the journal last year — coverage in Science and Nature followed — explained the purpose of the study:

Continue reading Retraction of grizzly bear-diabetes study follows departure of Amgen scientist for data manipulation