Category: freely available

At last, cancer reproducibility project releases some results — and they’re mixed

Nearly five years ago, researchers suggested that the vast majority of preclinical cancer research wouldn’t hold up to follow-up experiments, delaying much needed treatments for patients. In a series of articles publishing tomorrow morning, eLife has released the results of the first five attempts to replicate experiments in cancer biology — and the results are decidedly mixed.

As our co-founders Adam Marcus and Ivan Oransky write in STAT, the overall take-home message was that two studies generated findings similar to the original, one did not replicate the original, and two others were inconclusive.

They quote Brian Nosek, a psychologist at the University of Virginia, in Charlottesville, who runs the Center for Open Science, who has been leading the replication effort in his own field:

Continue reading At last, cancer reproducibility project releases some results — and they’re mixed

Breast cancer studies by fired Pfizer employee retracted

Last year, Pfizer fired one of its scientists following an investigation that ended with requests for retraction of five of her studies. Now, two of the five papers, which were first flagged on PubPeer, have been retracted.

One notice cites the Pfizer investigation, which found that cancer researcher Min-Jean Yin had included duplicated images in all five papers. Yin is the last author on both retracted papers.

Here’s the first notice from Clinical Cancer Research, which says most or all of the questioned images appear to be duplicates, and Pfizer — who sponsored the study and requested the retraction — can’t find the originals:
Continue reading Breast cancer studies by fired Pfizer employee retracted

“Crucial experiments” missing from retracted plant study

A 2016 study was retracted from a Frontiers journal after editors realized the authors had omitted experiments that didn’t support the hypothesis. 

Gearóid Ó Faoleán, ethics and integrity manager at Frontiers, which publishes Frontiers in Plant Science, told us:

In accordance with our complaints protocol, the Field Chief Editor led the investigation that resulted in the decision to retract the paper.

Here’s the retraction notice: Continue reading “Crucial experiments” missing from retracted plant study

Authors retract two statin papers, one with problems “too extensive to revise”

Researchers in China have retracted two 2016 papers about the possible use of a cholesterol-lowering agent to treat bleeding on the brain.

One of the retracted papers in the Journal of Neurosurgery (JNS) had multiple problems that were “too extensive to revise,” according to the lengthy retraction notice, relating to issues with authorship, data analyses, and patient enrollment. The notice is signed by first author Hua Liu of the Nanjing Medical University in China.

Liu is also the first author of another recently retracted paper in Frontiers in Neuroscience, pulled for incorrectly categorizing patients.

The JNS retraction notice begins: Continue reading Authors retract two statin papers, one with problems “too extensive to revise”

Journal retracts gastric cancer study with multiple duplications, authors MIA

An oncology journal has decided to retract a 2012 paper on gastric cancer after discovering duplicated data in multiple figures.

According to the retraction notice, the journal’s editorial board received a tip from a reader regarding the potential figure issues. Oncology Reports launched an investigation, which confirmed the allegations. The authors failed to respond to the journal’s multiple requests for more information.

Here’s the retraction notice: Continue reading Journal retracts gastric cancer study with multiple duplications, authors MIA

Authors retract tanning-UV radiation study for lacking approval

Researchers have agreed to pull a 2015 study exploring whether a plant extract can safeguard tanners from ultraviolet exposure after not obtaining formal approval from an ethics committee.

According to the first author, the problem lay in a misunderstanding – when they originally applied for approval six years ago, the researchers believed they didn’t need to go through a formal approval process, since the compound was commercially available without a prescription. Once they realized their mistake, they chose to retract the paper.

Here’s the retraction note for “Oral Polypodium leucomotos increases the anti-inflammatory and melanogenic responses of the skin to different modalities of sun exposures: a pilot study,” published in Photodermatology Photoimmunology & Photomedicine.  Continue reading Authors retract tanning-UV radiation study for lacking approval

Journal retracts surgery study with data “not intended for use in research”

A journal has retracted a surgery study by researchers at Brown University after noticing it included data that was not intended for research purposes. (Incidentally, the data were collected by the publisher of the journal.)

Ingrid Philbert, managing editor of the Journal of Graduate Medical Education — which published the paper — told Retraction Watch that senior staff at the publisher alerted the journal that they suspected the authors had used data from a confidential source:

This is a fairly new set of case log data, and as the collector [of] the data, the [Accreditation Council for Graduate Medical Education (ACGME)] gets to determine the use and it has decreed that this data be used solely for accreditation decisions.

Philbert said the journal asked the authors where they got the data:

Continue reading Journal retracts surgery study with data “not intended for use in research”

Nature paper with massive correction can’t be reproduced, says independent group

In 2011, authors of a Nature letter caught some flak for issuing a lengthy correction to a neuroscience paper that had raised eyebrows within days of publication — including some suggestions it should be retracted.

The correction notice, published months after the original letter, cited errors in image choice and labeling, but asserted the conclusions remained valid.

Now, those conclusions appear up for debate. In a recent Nature Brief Communications Arising (BCA) article, a team that raised concerns about the paper five years ago says they are unable to reproduce the results. But the authors of the original paper aren’t convinced: They argue that the BCA fails to cite important evidence, has a “complete absence or low quality of analysis,” and the scientists disregard some of their data.

Continue reading Nature paper with massive correction can’t be reproduced, says independent group

“An example for all authors to uphold:” Researcher logs 5 corrections

A scientist in Ireland has corrected five of his papers in a single journal dating back more than a decade, after image-related problems were brought to his attention.

Four of the newly corrected papers have a common last and corresponding author: Luke O’Neill of Trinity College Dublin in the Republic of Ireland. O’Neill is also a co-author of the remaining paper that was fixed. O’Neill told us the mistakes were a “bit sloppy,” noting that he takes responsibility for the errors in the four papers on which he is last author.

O’Neill forwarded Retraction Watch a comment he received from Kaoru Sakabe — data integrity manager at the American Society for Biochemistry and Molecular Biology (which publishes The Journal of Biological Chemistry (JBC)) — that reads:

Continue reading “An example for all authors to uphold:” Researcher logs 5 corrections

Japan group earns 4th retraction following investigation

Researchers in Japan have issued their fourth retraction, noting that the same figures were used to depict different experimental conditions.

The group lost two papers in 2015 for the same reason, following a misconduct investigation at Oita University in Japan. Last year, the same group notched another retraction, and pegged the responsibility for the problematic figures on first author Satoshi Hagiwara.

Now, the group has published a fourth retraction in the European Journal of Pharmacology; the latest notice doesn’t identify a culprit. All four retracted papers list Hagiwara as first author.

Here’s the latest retraction notice: Continue reading Japan group earns 4th retraction following investigation