Category: cell metabolism

NIH researcher responds as sleuths scrutinize high-profile study of ultra-processed foods and weight gain

via Hall et al, Cell Metabolism

[This post has been updated since publication; see update note at end for details.]

In July 2019, Kevin Hall, of the U.S. National Institutes of Health, and colleagues published a study in Cell Metabolism that found, according to its title, that “Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain.” 

A year and a half after its publication, the paper is the subject of two critical blog posts, one by Nick Brown and one by Ethan and Sarah Ludwin-Peery. In the days since we first shared embargoed drafts of those posts with Hall, he and the sleuths engaged in a back and forth, and Brown and the Ludwin-Peerys now say they are satisfied that many of the major issues appear to have been resolved. They have also made changes to their posts, including adding responses from Hall.

In short, it seems like a great example of public post-publication peer review in action. For example, the Ludwin-Peerys write:

When we took a close look at these data, we originally found a number of patterns that we were unable to explain. Having communicated with the authors, we now think that while there are some strange choices in their analysis, most of these patterns can be explained…

In a draft of their post shared with us early last week — see “a note to readers” below — the Ludwin-Peerys said that some of the data in the study “really bothered” them. In particular, they write, the two groups of people studied — 20 received ultra-processed foods, while 20 were given an unprocessed diet — “report the same amount of change in body weight, the only difference being that one group gained weight and the other group lost it.” They were also surprised by the “pretty huge” correlation between weight changes and energy intake.

Brown’s draft post, which digs into the data, concludes:

Continue reading NIH researcher responds as sleuths scrutinize high-profile study of ultra-processed foods and weight gain

Researchers retract two well-cited papers for misconduct

A scientist in Germany has lost two papers that were collectively cited more than 500 times, after an investigation at her former university found her guilty of scientific misconduct.

The probe into Tina Wenz by the University of Cologne in Germany, her former employer, recommended that six of her papers — which have induced some chatter on PubPeer — should be retracted. One of these papers was pulled by Cell Metabolism last year. Now, Cell Metabolism has pulled another of Wenz’s papers, and she has also lost another study published in the Proceedings of the National Academy of Sciences (PNAS), which was previously corrected. 

First, here’s the PNAS retraction notice, issued today: Continue reading Researchers retract two well-cited papers for misconduct

How a Cell journal weeds out the “bad apples”

Anne Granger (left) and Nikla Emambokus (right)
Anne Granger (left) and Nikla Emambokus (right)

There are a lot of accusations about research misconduct swirling around, and not every journal handles them the same. Recently, Cell Metabolism Scientific Editor Anne Granger and Cell Metabolism Editor-in-Chief Nikla Emambokus shared some details about their investigative procedure in “Weeding out the Bad Apples.” We talked to them about why they don’t necessarily trust accusations leveled on blogs (including ours), but will consider the concerns of anyone who approaches the journal directly – even anonymously.

Retraction Watch: What made you decide to write an editorial about research fraud now? Continue reading How a Cell journal weeds out the “bad apples”

German university recommends that six papers be retracted following probe

200px-siegel_uni-koeln_grau-svgThe University of Cologne has conducted an investigation into the research of Tina Wenz, and determined that six papers should be pulled due to scientific misconduct.

In a release issued last week (as first reported by Leonid Schneider), the university lists six papers that “present scientific misconduct,” according to our Google Translate.

One of the six papers was already retracted last year by Cell Metabolism, which cited reused northern and western blot band images in two figures.

The other six papers are: Continue reading German university recommends that six papers be retracted following probe

How can we improve preclinical research? Advice from a diabetes researcher

Daniel Drucker
Daniel Drucker

By all accounts, science is facing a crisis: Too many preclinical studies aren’t reproducible, leading to wasted time and effort by researchers around the world. Today in Cell Metabolism, Daniel Drucker at the Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital in Toronto details numerous ways to make this early research more robust. His most important advice: more transparent reporting of all results (not just the positive findings), along with quantifying, reporting, tracking, and rewarding reproducibility, for both scientists and journals and universities/research institutes.

Retraction Watch: Which of your recommendations will researchers most object to, and why? Continue reading How can we improve preclinical research? Advice from a diabetes researcher

Singapore investigation leads to two retractions, two more on the way

cov150hAuthors have retracted papers from Cell Metabolism and the Journal of Biological Chemistry after an investigation in Singapore found issues, including falsified data. The investigation is ongoing, and two additional retractions, along with two corrections, are on the horizon.

The investigation looked into papers by first authors Sudarsanareddy Lokireddy, now a postdoc at Harvard, and Sandhya Sriram, a postdoc at the Agency for Science, Technology and Research in Singapore. Led by the Nanyang Technological University in Singapore, where some of the work was done, the investigation concluded that there were issues with six papers on which either Sriram or Lokireddy was first author.

All authors but Lokireddy have agreed to retractions or corrections. Ravi Kambadur of NTU, and Mridula Sharma at the National University of Singapore, are the last two authors on all the papers.

According to a notice from the NTU, the “investigation found a number of instances of alterations to data” in three papers on which Lokireddy is first author. One of those was retracted December 1 by Cell Metabolism: Continue reading Singapore investigation leads to two retractions, two more on the way

University investigating duplicated images in retracted paper

Cell MetabolismThe authors of a Cell Metabolism paper are pulling it after discovering blot images that “appear more than once in independent and unrelated experiments.” 

Just how the duplication occurred in the 2009 paper — about transcription of mitochondrial DNA — remains a mystery, the authors note:

…the reasons for the errors are still under investigation…

Meanwhile, we’ve learned that the last author on the paper — Carlos Moraes of the University of Miami — has requested a retraction for another 2013 paper in Mitochondrion, also co-authored by Tina Wenz at the University of Cologne in Germany. That paper is among multiple publications co-authored by Moraes and Wenz that have been flagged on PubPeer.

We’ve reached out to the parties involved, and received a warning from an attorney representing Wenz that if we write about Continue reading University investigating duplicated images in retracted paper

Retraction of grizzly bear-diabetes study follows departure of Amgen scientist for data manipulation

cov150h
The retracted paper made the cover of the August 2014 issue of the journal.

A study that looked to hibernating bears to understand the mechanisms behind diabetes has been retracted because an author based at the biotech company Amgen “manipulated specific experimental data” in two figures.

According to the The Wall Street Journal, Amgen discovered the manipulation while reviewing the data following publication of the paper,”Grizzly bears exhibit augmented insulin sensitivity while obese prior to a reversible insulin resistance during hibernation.” Published in Cell Metabolism last year, the paper has been cited 8 times, according to Thomson Scientific’s Web of Knowledge.

A press release from the journal last year — coverage in Science and Nature followed — explained the purpose of the study:

Continue reading Retraction of grizzly bear-diabetes study follows departure of Amgen scientist for data manipulation

Authors retract leptin paper due to “fabricated data”

CellPress_ak2The authors of a study on the effects of the hormone leptin on the liver have retracted it from Cell Metabolism, almost four months after the Office of Research Integrity (ORI) determined it contained faked data, courtesy of its first author.

However, the authors say that the paper’s conclusions remain valid, and are supported by new experiments and additional research by outside groups.

Here’s more from the retraction notice: Continue reading Authors retract leptin paper due to “fabricated data”

Former University of Utah researchers, one guilty of “reckless disregard,” have another paper retracted

cell metabolismA pair of University of Utah researchers who both left their posts last year following an investigation into problems with their work have had another paper retracted from Cell Metabolism.

The investigation found “reckless disregard” in papers in which Ivana De Domenico was first author. She left the university at the end of June 2013, and and her lab head, Jerry Kaplan, retired at the same time.

Here’s the notice for 2008’s “The Hepcidin-Binding Site on Ferroportin Is Evolutionarily Conserved:” Continue reading Former University of Utah researchers, one guilty of “reckless disregard,” have another paper retracted