Category: british j of cancer

Suspicions of data manipulation lead to correction of testicular cancer paper

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The corresponding author of a paper on testicular cancer is telling readers to discount a figure after she learned it may have been manipulated.

Although that one figure in the 2005 paper in the British Journal of Cancer may be problematic, the authors found data to support the other figures, and its conclusions.

This isn’t the first time first author Kerry Manton has faced questions over her data — in 2012, one of her papers was retracted following an investigation by her institution, the Queensland University of Technology. And in 2014, QUT repaid a $275,000 grant after finding Manton

failed to fulfill (her) responsibilities in relation to the responsible dissemination of research findings and that this, coupled with a failure to correct the errors, constituted research misconduct.

Here’s the corrigendum for “Hypermethylation of the 5′ CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis:”

Continue reading Suspicions of data manipulation lead to correction of testicular cancer paper

Researchers retract breast cancer study after realizing they were using the wrong antibody

br j cancerA group of researchers at Istanbul University has swiftly retracted a paper they published in March in the British Journal of Cancer once it became clear that they were using the wrong antibody.

Here’s the notice for “Clinical significance of p95HER2 overexpression, PTEN loss and PI3K expression in p185HER2-positive metastatic breast cancer patients treated with trastuzumab-based therapies:” Continue reading Researchers retract breast cancer study after realizing they were using the wrong antibody

Cancer biology group notches sixth retraction, and earns an Expression of Concern

bjcA group at the University of Texas Southwestern that retracted five papers last year has retracted one more, and has had a paper subjected to an Expression of Concern at the request of the school’s dean.

Here’s the retraction notice for “DNA methylation-associated inactivation of TGFβ-related genes, DRM/Gremlin, RUNX3, and HPP1 in human cancers,” originally published in the British Journal of Cancer and cited 51 times, according to Thomson Scientific’s Web of Knowledge:
Continue reading Cancer biology group notches sixth retraction, and earns an Expression of Concern

Another retraction for Pfizer’s experimental cancer treatment figitumumab

6794 BJC_newblue_V1.qxdLast month, we brought you news that Pfizer had retracted a paper in the Journal of Clinical Oncology

purporting to show a benefit of their experimental drug for lung cancer figitumumab after discovering that its clinical lead on the project had done analyses improperly.

There’s been another retraction, of a related paper, in the British Journal of Cancer, “Pre-treatment levels of circulating free IGF-1 identify NSCLC patients who derive clinical benefit from figitumumab.” Here’s the notice: Continue reading Another retraction for Pfizer’s experimental cancer treatment figitumumab

Five retractions for cancer research team for manipulated figures

The International Journal of Cancer, a Wiley title, has retracted a pair of articles from a group at UT Southwestern Medical Center in Dallas, for image manipulation.

The papers, from the lab of Adi Gazdar, the W. Ray Wallace Distinguished Chair in Molecular Oncology Research who is known for his massive collection of human cancer cells, were published in 2005.

The first was titled “Aberrant methylation of Reprimo in human malignancies.” According to the retraction notice: Continue reading Five retractions for cancer research team for manipulated figures

Inability to reproduce Dutch grad student’s data prompts two retractions from the cancer lit

We are watching an intriguing case out of the Netherlands, involving a young researcher whose dubious results have led to the retraction of a pair of papers.

The retracted articles, which appeared in 2008 in Cancer Research and the British Journal of Cancer, come from the lab of the prominent Dutch scientist Ed Roos, of the Netherlands Cancer Institute in Amsterdam. Both papers addressed the actions of certain chemokine receptors — molecules on cell surfaces that interact with blood proteins involved in the immune response — on the behavior of tumor cells.

The first author on each paper was Joost Meijer, at the time a graduate student in Roos’ shop.

The retraction notices contain essentially the same information, although in the case of the BJC article — “Effect of the chemokine receptor CXCR7 on proliferation of carcinoma cells in vitro and in vivo” — the letter is quite personal. Dated Jan. 4, 2011, it reads: Continue reading Inability to reproduce Dutch grad student’s data prompts two retractions from the cancer lit