Do scientists need audits?

Viraj Mane
Viraj Mane
Amy Lossie
Amy Lossie

If audits work for the Internal Revenue Service, could they also work for science? We’re pleased to present a guest post from Viraj Mane, a life sciences commercialization manager in Toronto, and Amy Lossie at the National Institutes of Health, who have a unique proposal for how to improve the quality of papers: Random audits of manuscripts.

Skim articles, books, documentaries, or movies about Steve Jobs and you’ll see that ruthlessness is the sine qua non of some of our greatest business leaders. It would be naïve to assume that scientists somehow resist these universal impulses toward leadership, competition, and recognition. In the white-hot field of stem cell therapy, where promising discoveries attract millions of dollars, egregious lapses in judgment and honesty have been uncovered in Japan, Germany, and South Korea. The nature of the offenses ranged from fraudulent (plagiarism and duplication of figures) to horrifying (female subordinates coerced into donating their eggs).

When a researcher embraces deception, the consequences extend well beyond the involved parties. Former physician Andrew Wakefield published a linkage between MMR vaccines and autism with overtly substandard statistical and experimental methods, while hiding how his financial compensation was tied to the very hysteria he helped unleash.

Let’s ask some hard questions. Continue reading Do scientists need audits?

News site The Intercept says reporter created fake quotes, sources

interceptThe Intercept is apologizing to readers after an investigation revealed one of its reporters fabricated multiple quotes and even created a fake email address for a source to deceive his editors.

The online news site is retracting and correcting several articles by former staff writer Juan Thompson, who was employed there from November 2014 until last month.

In a note issued earlier today, editor Betsy Reed revealed some details of the results of the investigation to readers:

Continue reading News site The Intercept says reporter created fake quotes, sources

“Innocent mistake” leads to bioethics article retraction

jbiA July article that incorrectly called out nine leading bioethics journals for their lack of availability to researchers in low- and middle-income countries is being pulled after editors of the indicted journals refuted the allegations.

The last author on the article, published in the Journal of Bioethical Inquiry, told us an “innocent mistake” and difficulty navigating a website led the authors to incorrectly note that nine journals had not made their contents available through the World Health Organization’s Health InterNetwork Research Initiative database (HINARI), which gives bioethicists who live in low- and middle-income countries access to research articles either free of charge or at reduced cost. The authors argued that the mistake didn’t affect the paper’s conclusions, but the journal disagreed, and opted to pull the paper entirely.

After searching through the database, first author Subrata Chattopadhyay mistakenly determined that the journals had not made their contents available through HINARI, when in fact they were listed but on a different part of the website.

Even with the error, the authors maintain that their conclusions remain sound and that the field is shaped by a “hegemony of Western bioethics.” Continue reading “Innocent mistake” leads to bioethics article retraction

EMBO takes back Voinnet’s award, investigates other awardee who just lost a Nature Genetics paper

Screen Shot 2016-01-28 at 11.41.20 AMEMBO has taken back an award given to beleaguered plant biologist Olivier Voinnet in 2009, and is investigating a recent grantee who had a paper retracted from Nature Genetics yesterday.

The European Molecular Biology Organization (EMBO) “promotes excellence in the life sciences” in Europe, in part by awarding prizes to promising young scientists. Voinnet and Sonia Melo earned their awards by exhibiting potential as young scientists studying genetics — of plants and cancer, respectively — but now EMBO is skeptical of the papers that formed the basis of their applications.

Melo’s Installation Grant from EMBO was announced just last month, and consists of 50,000 Euros annually for three to five years. She is currently based at the University of Porto, in Portugal.

Voinnet’s problems are well-documented on this blog — 21 corrections, seven retractions, and two investigations. Earlier this week, we reported that the Swiss National Science Foundation had cut off Voinnet’s funding, and banned him for three years. Continue reading EMBO takes back Voinnet’s award, investigates other awardee who just lost a Nature Genetics paper

Investigation of undisclosed conflicts in catheter paper uncovers flawed data, too

cov150hAn investigation into a paper that compared infection rates from different types of central lines started with an allegation about a failure to disclose a conflict of interest, and ended up concluding that the science in the paper was flawed.

The 2013 paper — now retracted by the American Journal of Infection Control — suggested a particular kind of connector between the catheter and the patient could reduce some of the notoriously deadly bloodstream infections associated with the procedure, according to a press release that publicized the work. But last year, the journal issued an expression of concern for the paper, noting there were questions about the data. The retraction note reveals an investigation at Georgia Regents University — now known as Augusta University — started looking into undisclosed conflicts of interest in the paper, and ultimately concluded the science was flawed.

Here’s the retraction note, published in the January 1st 2016 issue of the journal, for “Comparison of central line-associated bloodstream infection rates when changing to a zero fluid displacement intravenous needleless connector in acute care settings

Continue reading Investigation of undisclosed conflicts in catheter paper uncovers flawed data, too

What to do when you make a mistake? Advice from authors who’ve been there

cpp-150After a group of researchers noticed an error that affected the analysis of a survey of psychologists working with medical teams to help pediatric patients, they didn’t just issue a retraction — they published a commentary explaining what exactly went wrong.

The error was discovered by a research assistant who was assembling a scientific poster, and noticed the data didn’t align with what was reported in the journal. The error, the authors note, was:

an honest one, a mistake of not reverse coding a portion of the data that none of the authors caught over several months of editing and conference calls. Unfortunately, this error led to misrepresentation and misinterpretation of a subset of the data, impacting the results and discussion.

Needless to say, these authors — who use their “lessons learned” to help other researchers avoid similar missteps — earn a spot in our “doing the right thing” category. The retraction and commentary both appear in Clinical Practice in Pediatric Psychology.

Their first piece of advice in “Retraction experience, lessons learned, and recommendations for clinician researchers” — assume errors will happen, and not vice versa: Continue reading What to do when you make a mistake? Advice from authors who’ve been there

Paper on the adhesiveness of a material doesn’t stick

1-s2.0-S0169433215X00213-cov150hApplied Surface Science has retracted an article that looks at the structure of thin tungsten-titanium coating, because it was submitted without all of the co-authors’ consent.

According to the introduction of the paper, “Structure adhesion and corrosion resistance study of tungsten bisulfide doped with titanium deposited by DC magnetron co-sputtering,” such thin films are “widely used as a surface treatment for optimizing base material properties.”

Here’s the retraction note in full, published in the September issue of the journal:

Continue reading Paper on the adhesiveness of a material doesn’t stick

Can a journal retract its plan to retract? Science may

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Science is reconsidering its plan to retract a paper about using RNA to make palladium nanoparticles after one of the authors submitted a last-minute correction.

Editor in chief Marcia McNutt told us that the journal will make a decision about whether to retract or correct the paper by February 5th.

We are not certain that what he submitted changes anything, but we wanted to consider this new information before acting.

In the meantime, today the journal issued an Expression of Concern for the paper.

The journal’s initial decision to retract the paper stemmed from an investigation at the National Science Foundation, which concluded that co-authors Bruce Eaton and Dan Feldheim — currently at the University of Colorado at Boulder — engaged in “a significant departure from standard research practices,” and cut them off from NSF funding unless they took specific actions. When the report on the investigation came to light earlier this month, Science editor in chief Marcia McNutt told us that she planned to issue a retraction:

We are checking to see how soon we can get it published.

McNutt explained what changed:  Continue reading Can a journal retract its plan to retract? Science may

So, pot may not be as harmless as a recent study suggested

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Researchers are correcting a widely covered study that suggested chronic use of pot might not put users at risk of problems later in life.

It turns out that initial, unexpected finding — covered by Newsweek, The Washington Post, Quartzand (of course) The Stoner’s Cookbook (now known as HERB) wasn’t quite right, and a reanalysis found users had a small uptick in risk for psychosis. The authors have issued a lengthy correction in Psychology of Addictive Behaviors that includes some supplemental analysis, too.

Not surprisingly, the study’s findings engendered some controversy, which prompted the authors to reanalyze their data, collected from 408 males with varying levels of marijuana use, who were followed from their teens into their 30s.

Now, an American Psychological Association press release that accompanied the initial findings in August contains an editors note explaining why those aren’t quite correct:

Continue reading So, pot may not be as harmless as a recent study suggested

Lawsuit against Ole Miss for rescinded Sarkar job offer dismissed; briefs filed in PubPeer case

court caseWe recently obtained court documents showing that, in September, a judge dismissed a lawsuit filed by cancer researcher Fazlul Sarkar against the University of Mississippi after it rescinded a job offer after reviewing concerns raised about his research on PubPeer.

Sarkar’s connection to PubPeer will be familiar to many readers — he has also taken the site to court to force them to reveal the identity of the anonymous commenters who have questioned his findings. He has accused the commenters of defamation, arguing they cost him the job offer. Today, the American Civil Liberties Union filed a brief on behalf of PubPeer’s appeal of the court’s most recent ruling, that the site must disclose the identity of an anonymous commenter. At the same time, some heavy hitters in science – Bruce Alberts and Harold Varmus — and technology — Google and Twitter — filed briefs in support of the appeal.

The lawsuit against Ole Miss has brought to light the reasoning behind the school’s decision to rescind their offer to Sarkar — and the key role played by the concerns raised on PubPeer.

In a letter dated June 19, 2014 to Sarkar from Larry Walker, the director of the National Center for Natural Products Research at the University of Mississippi, Walker chides Sarkar for not revealing the extent of the ongoing questions over his research during the interview process:

Continue reading Lawsuit against Ole Miss for rescinded Sarkar job offer dismissed; briefs filed in PubPeer case