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Liver spots: Hepatology journal yanks research letter on caffeine-fibrosis link, saying authors falsified data

Work from a prolific father-son team of liver researchers in Germany has come under scrutiny after accusations that they falsified data in a 2009 letter to the editor that appeared in the Journal of Hepatology.

The letter, retracted in the September issue (after an online notice in June), referred to a 2008 article in the journal by Axel Gressner, his son Olav, and their colleagues at University Hospital in Aachen in which the authors reported that doses of caffeine might be an effective treatment for liver fibrosis, scarring of the organ that results from chronic ailments such as cirrhosis or hepatitis.

Epidemiologic evidence has suggested that people who drink coffee are somewhat protected from liver fibrosis—although some experts dispute the purported connection—and the German group claimed to have been among the first to find a plausible molecular mechanism for the link. Their November 2008 paper on the subject has been cited 16 times, according to Thomson Scientific’s Web of Science, a hefty number for just 22 months.

In their follow-up letter, they went a step further, stating that injecting rats with caffeine blocked the expression of a key protein associated with growth of connective tissue necessary for the formation of liver scars.

But the evidence backing the letter appears to be far weaker than the researchers initially let on. Continue reading Liver spots: Hepatology journal yanks research letter on caffeine-fibrosis link, saying authors falsified data

Double trouble: Psych journal prints PTSD paper twice

Aging & Mental Health “welcomes original contributions” to fill its pages.

Or not so original. Last November, the journal published a study by two California researchers which looked at the possible effects of post-traumatic stress disorder on physical well-being in older women – and found no evidence of such a link.

Six months later, the journal published the findings again.

It issued a retraction earlier this month, which included the following: Continue reading Double trouble: Psych journal prints PTSD paper twice

Did a NOAA scientist “retract” an overoptimistic oil spill report?

Photo by Mindful Walker http://www.flickr.com/photos/27530874@N03/ via flickr

Yesterday, on a story about a Congressional hearing on the progress of oil spill cleanup in the Gulf of Mexico, the Guardian ran the following headline:

BP oil spill: US scientist retracts assurances over success of cleanup

NOAA’s Bill Lehr says three-quarters of the oil that gushed from the Deepwater Horizon rig is still in the Gulf environment while scientists identify 22-mile plume in ocean depths

The story, as do those in the Los Angeles Times, The Hill, and the New Orleans Times-Picayune, among others, point out that Lehr’s testimony seemed at odds with the almost celebratory atmosphere surrounding the release of a National Oceanic and Atmospheric Administration (NOAA) report two weeks ago, “BP Deepwater Horizon Oil Budget: What Happened To the Oil?”

The coverage yesterday also noted that other scientists have criticized the report, and that a study in Science this week suggests there’s still an underwater plume of oil in the Gulf.

But did Lehr actually “retract” assurances over the cleanup’s success, or the report itself? Continue reading Did a NOAA scientist “retract” an overoptimistic oil spill report?

It’s not a tumor: Authors retract 2005 Cancer Research paper linking adult stem cells to cancer

The authors of a 2005 Cancer Research paper that cast some doubt on the safety of a population of adult stem cells used frequently in research have retracted it. According to the retraction, in the August 15 issue of the journal:

Upon review of the data published in this article, the authors have been unable to reproduce some of the reported spontaneous transformation events and suspect the phenomenon is due to a cross-contamination artifact.

Transformation refers to changes in the cells that make them “immortal” — think HeLa cells, made popular by Rebecca Skloot’s book about Henrietta Lacks — and cancer-like. Continue reading It’s not a tumor: Authors retract 2005 Cancer Research paper linking adult stem cells to cancer

American Cancer Society drops ‘Screening is Seeing’ ad campaign

When we started Retraction Watch, Gary Schwitzer suggested that one of us might be a vampire.

Well, Schwitzer, let us say this: You are no Jesus.

However, criticism leveled by Schwitzer at an American Cancer Society (ACS) ad campaign earlier this week has accomplished the Retraction Watch equivalent of turning water into wine. The campaign, he wrote, Continue reading American Cancer Society drops ‘Screening is Seeing’ ad campaign

Shifting gears: Occupational health journal pulls study linking shift work, age and sleep disorders

Blaming “data coding errors,” the Journal of Occupational and Environmental Health has pulled an article linking shift work, age and sleeping problems.

The study was published four months ago, but managed in its brief lifespan to garner significant attention in the mainstream media and the blogosphere, although it has not been cited by any other papers. It comes alongside growing interest in the potential lnks between shift work and various health conditions including irritable bowel syndrome and breast cancer. Denmark even awards damages to shift workers who have developed the latter.

Ironically, the researchers, led by Philip Tucker, of Swansea University in Wales, U.K., had hoped to demonstrate the toll of shift work that previous studies were unable to show conclusively because of “methodological difficulties”: Continue reading Shifting gears: Occupational health journal pulls study linking shift work, age and sleep disorders

The shroud of retraction: Virology Journal withdraws paper about whether Christ cured a woman with flu

Jesus healing a bleeding woman, courtesy http://campus.belmont.edu/honors/CatPix/womanblood.jpg via Wikipedia

It takes decades, and even centuries, to overturn the Catholic canon of law, but medical journals move much more quickly: Just three weeks after the Virology Journal published a paper speculating that a woman described in the Bible as being “cured by our Lord Jesus Christ” had flu, the journal has apologized for ever posting it online.

After bemused — to put it mildly — reactions from bloggers Bob O’Hara (who alerted us to the retraction), P.Z. Myers, and Tara C. Smith, as well as questions from a journal reader, the journal’s editor, Robert F. Garry, posted a retraction to O’Hara’s blog, and in his own journal: Continue reading The shroud of retraction: Virology Journal withdraws paper about whether Christ cured a woman with flu

Double negatives: Four years later, a journal restores retracted headache paper

drawing by JD Fletcher via Wikipedia http://en.wikipedia.org/wiki/File:Clusterhead.jpg

It might not be a first – although we can’t find another example — but a mental health journal has reinstated an article it retracted four years ago.

The retracted retraction notice appears in the August issue of the Journal of Neurology, Neurosurgery & Psychiatry, a BMJ title, and refers to a 2005 article describing an alarming case of treatment-related emotional problems in a patient with cluster headaches.

These headaches, which often strike behind the eyes, are akin to migraines and have been dubbed “suicide headaches” because they are so intensely painful that many sufferers have said that death would be a preferable fate. (Think: “It beats a poke in the eye with a sharp stick.”)

The patient had been taking high doses of the drug methysergide and began to experience Continue reading Double negatives: Four years later, a journal restores retracted headache paper

Monkey business? 2002 Cognition paper retracted as prominent psychologist Marc Hauser takes leave from Harvard

Marc Hauser, a prominent Harvard psychology researcher and author, will be taking a leave of absence from the university following “a lengthy internal investigation found evidence of scientific misconduct in his laboratory” that has led to the retraction of one of his papers, according to The Boston Globe.

The retraction, of a 2002 paper in Cognition, reads, in part: “An internal examination at Harvard University . . . found that the data do not support the reported findings. We therefore are retracting this article,” the Globe reports.  It also includes the sentence “MH accepts responsibility for the error.”

The retraction notice does not yet appear anywhere on the journal’s site, where the PDF version of the study is still available, nor on the Medline abstract. Its circumstances appear to be atypical, according to the Globe: Continue reading Monkey business? 2002 Cognition paper retracted as prominent psychologist Marc Hauser takes leave from Harvard

Science wants “reactome array” enzyme chip authors to retract paper

Following an investigation into an October 2009 study in Science that claimed to have proven the ability of a device to measure all of the enzyme activity in a cell at a particular time, the journal has asked the study’s authors to retract the paper, Science‘s news blog, ScienceInsider, reported on Friday.

The move comes after Bruce Alberts, Science‘s editor in chief, issued an Editorial Expression of Concern in December in response to concerns raised by other scientists

to alert our readers to thefact that serious questions have been raised about the methodsand data presented in this article. The questions focus in particularon the synthesis of the dye-labeled metabolites that are centralto the microarray technique. In addition, the spectroscopicdata the authors cite in support of their claim were not postedto the Bangor University School of Biological Sciences Web siteat the time of publication, despite the authors’ indicationin the Supporting Online Material that the data would be soposted. In response to inquiries from Science, the authors haveprovided new descriptions of the synthetic methods that differsubstantially from those in their published article. Based onour original concerns and the authors’ response, Science hasrequested evaluation of the original data and records by officialsat the authors’ institutions: These officials have agreed toundertake this task.

That evaluation, reported late last month by Nature, concluded Continue reading Science wants “reactome array” enzyme chip authors to retract paper