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JAMA issues mega-correction for data breach letter due to “wording and data errors”

s_cover_jcv062315A JAMA letter published in April on data breaches accidentally included some data that shouldn’t have been published, either — specifically, “wording and data errors” that affected five sentences and more than 10 entries in a table. One result — a reported increase in breaches over time — also went from statistically significant to “borderline” significant, according to the first author. (So yeah, this post earns our “mega correction” category.)

According to an author, an “older version” of a table made it into the letter, “Data Breaches of Protected Health Information in the United States,” which was corrected in the journal’s June 23/30 issue.

The letter and table in question detail 949 breaches of “unencrypted protected health information.”  The letter says the number of breaches has increased from 2010 to 2013; the original article claimed that the P value on that increase was <.001, but the correction says it’s really 0.07. The original says 29.1 million personal records were affected in those breaches; the real number is 29.0. And so on.

Continue reading JAMA issues mega-correction for data breach letter due to “wording and data errors”

Cancer Research retraction is fifth for Robert Weinberg; fourth for his former student

13.coverAnother domino has fallen in a chain of retractions for Robert Weinberg, the man who discovered the first tumor-causing gene in humans, along with the first tumor suppressor gene: Cancer Research just retracted a paper of his on some of the molecular steps to metastasis.

The paper, “Concurrent Suppression of Integrin α5, Radixin, and RhoA Phenocopies the Effects of miR-31 on Metastasis,” has been cited 70 times, according to Thomson Scientific’s Web of Knowledge. As we have noted before, Weinberg’s papers are frequently highly cited. His bio at the Whitehead Institute bills him as “a pioneer in cancer research.”

Four of Weinberg’s retracted papers — including this latest — share a first author: Scott Valastyan, once a very promising grad student in Weinberg’s lab. 

This retraction, like Valastyan’s others, is linked to his retracted 2009 Cell paper. (That paper was cited 482 times, and there’s even a video from the Cell press office to go with it). Continue reading Cancer Research retraction is fifth for Robert Weinberg; fourth for his former student

Another author withdrawal from JBC earns another opaque notice

Journal of Biological Chemistry1The authors of a 2014 study on the biochemical changes that can encourage the progression of cancer have withdrawn the paper from the Journal of Biological Chemistry.

The post from the JBC – which we’ve noted are rarely helpful – doesn’t provide any details or reason for the withdrawal. As usual, this is all we got:

Continue reading Another author withdrawal from JBC earns another opaque notice

Misidentified genetic sequence causes retraction of pathogen paper one month after publication

Genome Announcements

The author of an article mapping the genome of an infectious bacterium is pulling the paper because — well, it wasn’t the bacterium she thought it was.

Study author Celia Abolnik is retracting her paper in Genome Announcements because it didn’t actually map out the DNA of Mycoplasma meleagridis, a bacterium that typically infects turkeys but has recently been found in chickens.

The trouble was, the sequence for Mycoplasma meleagridis in the National Institute of Health’s DNA database, Genbank, was actually a different variety of bacteria — Mycoplasma gallinaceum, another scourge of poultry.

Here’s the notice for “Complete Genome Sequence of Mycoplasma meleagridis, a Possible Emerging Pathogen in Chickens:”

Continue reading Misidentified genetic sequence causes retraction of pathogen paper one month after publication

Corrections (and one EoC) propagate for distinguished plant biologist, Olivier Voinnet

Olivier Voinnet
Olivier Voinnet

There may be some deeply rooted issues in the work of high-profile plant biologist Olivier Voinnet, biology department research director at ETH in Zurich. Corrections have continued to pile up months after his work was hit with a barrage of criticism on PubPeer. We’ve tracked a total of seven corrections over the past five months (not including the April retraction of a 2004 paper in The Plant Cell). One of the corrected papers also received an Expression of Concern this week.

Collectively, the corrected papers have accumulated more than 1200 citations.

In January, Voinnet said he planned to correct multiple papers, after receiving “an anonymous email.”

One of the recent corrections we found is for a 2003 article in The Plant Journal, “An enhanced transient expression system in plants based on suppression of gene silencing by the p19 protein of tomato bushy stunt virus,” which details using proteins from a tomato virus to help alter gene expression. The study has been cited 862 times, according to Thomson Scientific’s Web of Knowledge. Here’s the correction notice, posted June 8:

Continue reading Corrections (and one EoC) propagate for distinguished plant biologist, Olivier Voinnet

AIDS vaccine fraudster sentenced to nearly 5 years in prison and to pay back $7 million

court case

A researcher who confessed to spiking rabbit blood samples to make the results of an HIV vaccine experiment look better has been sentenced to 57 months of prison time, according to The Des Moines Register.

Dong-Pyou Han has also been ordered to repay more than $7 million to the U.S. National Institutes of Health, and will have three years of supervised release following his prison term.

In December, 2013, the U.S. Office of Research Integrity announced that Han, formerly at Iowa State University (ISU), had faked his results to make an HIV vaccine look more powerful. The faulty data made their way into seven national and international symposia between 2010 and 2012 (resulting in a retracted poster in 2014), along with three grant applications and multiple progress reports. Han agreed to a three-year research ban, and resigned from ISU in October the following year.

The NIH never sent the final $1.38 million grant payment of more than $10 million awarded to Han’s boss, Michael Cho, and ISU returned nearly $500,000 it had received for Han’s salary and other costs.

However, Continue reading AIDS vaccine fraudster sentenced to nearly 5 years in prison and to pay back $7 million

Duke University lung researchers cough up fourth retraction, due to “inconsistent” data

Journal of Applied PhysiologyThe Journal of Applied Physiology has retracted a 2012 respiratory study after the authors found “inconsistent” data that “could not be traced to their source.” It’s the fourth retraction for two of the researchers, including Erin Potts-Kant, who was arrested in 2013 for embezzling more than $14,000 from Duke University.

The study, “Effects of corticosteroid treatment on airway inflammation, mechanics, and hyperpolarized 3He magnetic resonance imaging in an allergic mouse model,” looked at how corticosteroid therapy, a steroid treatment used for asthma, worked on mice. It’s been cited four times, according to Thomson Scientific’s Web of Knowledge, and was one of the products of the environmental lung health research conducted by Potts-Kant and Duke professor William Foster, the other co-author on the retracted studies.

Here’s the complete retraction notice: Continue reading Duke University lung researchers cough up fourth retraction, due to “inconsistent” data

Macchiarini co-author objects to investigation’s misconduct verdict

dr-paolo-macchiarini
Paolo Macchiarini

One of Paolo Macchiarini’s co-authors on a 2011 Lancet paper describing an allegedly groundbreaking procedure to transplant an artificial trachea seeded with stem cells is objecting to a recent investigation that concluded Macchiarini had committed misconduct.

Ola Hermanson, who studies neural stem cells at Karolinska Institutet, argued in a report dated June 29 that the investigation contained “serious flaws and formal errors.”

Hermanson’s lengthy response (uploaded here except for supporting emails) is to the findings of an external review of allegations about Macchiarini’s work, conducted by Bengt Gerdin, of Uppsala University. In regards to the 2011 Lancet paper, Gerdin’s investigation found:

Continue reading Macchiarini co-author objects to investigation’s misconduct verdict

“Values were outside expected ranges”: Toxicology paper spiked after audit

Toxicological PathologyResearchers at the National Institute of Environmental Health Sciences have retracted a 2014 article after a review unearthed unresolved problems with the study’s control material.

The retracted paper, “Effect of Temperature and Storage Time on Sorbitol Dehydrogenase Activity in Sprague-Dawley Rat Serum and Plasma,” looked to test the durability and stability of sorbitol dehydrogenase, an enzyme used to detect cancerous liver damage in rats.

Here’s the complete retraction notice from Toxicologic Pathology :

Continue reading “Values were outside expected ranges”: Toxicology paper spiked after audit

JBC cancer paper felled by duplication is one author’s second retraction this month

25.coverA 2002 paper in the Journal of Biological Chemistry on how lung cancer cells resist death has been retracted for duplicating figures from a 2001 paper.

The retracted paper, “Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced apoptosis,” shares the first and last authors with the 2001 paper, in Oncogene, as well as two other co-authors.

Here’s JBC’s entire retraction note, a sub-genre with which we’ve become intimately familiar by now:

Continue reading JBC cancer paper felled by duplication is one author’s second retraction this month