Project to “fact check” genetic studies leads to three more retractions. And it’s just getting started.

Jennifer Byrne

A project to identify studies doomed by problematic reagents has triggered three more retractions, bringing the total to five.

Jennifer Byrne, a scientist at the University of Sydney, who developed the the idea of double-checking the nucleic acid sequences of research materials — thereby ensuring studies were testing the gene in question — told Retraction Watch that all three retractions came after she started emailing journals in January  to alert them to the problems: Continue reading Project to “fact check” genetic studies leads to three more retractions. And it’s just getting started.

Two more retractions for former US prof who altered dozens of images

Two journals have retracted papers by a biologist who was recently found guilty of misconduct by his former employer, the University of Colorado Denver, bringing the total to five.

The investigation report by UC Denver, which we obtained earlier this year via a public records request, had recommended one of the two newest retractions, which appears in the journal Hepatology. The other retraction, in the Journal of Immunology, was not flagged by the report — which found, among other conclusions, that Almut Grenz had altered multiple values in research that had already been submitted for peer review.

Here’s the notice for the Journal of Immunology paper:

Continue reading Two more retractions for former US prof who altered dozens of images

Bone researcher is up to 17 retractions

A bone researcher has lost three more papers for scientific misconduct.

The new retractions bring Yoshihiro Sato’s total to 17 and put him on our Leaderboard.

According to the retraction notices, Sato asked the Journal of Neurology, Neurosurgery, and Psychiatry to retract three of his papers “due to scientific misconduct.” In the letter, Sato—who is corresponding author on all three papers—explained he included co-authors without their consent and that none of the other authors listed worked on the study or article.

In May, the editors issued expressions of concern while they investigated (1, 2, 3), and last month, the journal retracted the three articles.

Here’s the retraction notice for “Amelioration of osteopenia and hypovitaminosis D by 1alpha-hydroxyvitamin D3 in elderly patients with Parkinson’s disease:” Continue reading Bone researcher is up to 17 retractions

Authors withdraw study, citing “accidentally duplicated” images

Researchers in Australia have withdrawn a 2006 paper in The Journal of Biological Chemistry (JBC), citing image duplication.

In the withdrawal notice, published July 14, 2017, the authors claim that the “errors do not impact the underlying scientific findings of the article.”

Although the notice does not mention an investigation, a comment on PubPeer on March 2017—signed by Mark Hargreaves, the vice-chancellor at the University of Melbourne—indicates that the university conducted an investigation to assess the issues in the paper and determined that research misconduct “did not occur.”

Here’s the withdrawal notice for “Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1:” Continue reading Authors withdraw study, citing “accidentally duplicated” images

Author who previously claimed plagiarism was a mistake earns new erratum

A biotechnology journal has corrected a 2006 paper after discovering duplication and plagiarism.

This offense is the second we know of for the corresponding author, Uttam Chand Banerjee, in the same journal, Applied Microbiology and Biotechnology. Last year, Banerjee—who works at National Institute of Pharmaceutical Education and Research (NIPER) in Mohali, Punjab, India—had a 14-year-old review retracted in Applied Microbiology and Biotechnology after an investigation revealed the authors had plagiarized from numerous sources and failed to reference them. At the time, Banerjee told us that he and his co-authors took a few lines from other reviews and that omitting the references was “simply unintentional.” According to The Indian Express, Banerjee also faced plagiarism allegations in 2005, and was denied a prestigious fellowship in 2011 as a result. Continue reading Author who previously claimed plagiarism was a mistake earns new erratum

UCSF, VA investigations find “clear evidence” of misconduct in cancer papers

Earlier this year, the University of California, San Francisco and the San Francisco Veterans Administration Medical Center teamed up to write a letter.

Addressed to the editorial office at the American Association of Cancer Research (AACR), the letter, parts of which have been published in a retraction notice, contained information concerning two papers on genetic risk factors for a type of kidney cancer and a type of uterine cancer, respectively, published in different AACR journals over a decade ago by researchers affiliated with the institutions.

The papers had been at the center of research misconduct investigations at both UCSF and the VA and the investigations came to the conclusion that both papers contained:

fabrication or falsification of data that constitutes Research Misconduct.

Though one of the papers has been retracted, it’s unclear what will happen to the other. [Note: See update at the bottom of the post.] Continue reading UCSF, VA investigations find “clear evidence” of misconduct in cancer papers

Data fabrication by ex-Harvard researcher takes down paper on Huntington’s disease

A researcher at Harvard Medical School and Massachusetts General Hospital is retracting a paper due to “inappropriate manipulation and fabrication of data” by the first author.

According to the retraction notice, published Aug. 22, corresponding author Marian DiFiglia is retracting the paper because the alleged misconduct by the first author, Antonio Valencia:

led to an incorrect conclusion in the paper that NADPH activity is elevated in Huntington’s disease (HD). Some original data were missing and efforts to replicate findings using the reported method or an alternative approach were unsuccessful. An institutional faculty panel supports the decision and the reasons for the retraction.

The notice added that the alleged data manipulation and fabrication affected bar graphs in two of the paper’s figures.

Terri Ogan, a spokesperson for Mass General, told Retraction Watch that Valencia no longer works at the institution, but declined to say whether there has been an investigation into the alleged misconduct: Continue reading Data fabrication by ex-Harvard researcher takes down paper on Huntington’s disease

Authors retract Science paper after investigation reveals manipulated images

Researchers at a prominent Japanese university have retracted a 2015 paper in Science, after an investigation uncovered image falsification and fabrication.

Last September, the University of Tokyo began an investigation of seven papers from the lab of cell biologist Yoshinori Watanabe after receiving anonymous allegations. In May 2017, the university determined that five papers contained falsified or fabricated images, and announced the results of its investigation on August 1. Two of the papers were published in Science, two in Nature and one in EMBO Reports.

On July 1 2017, EMBO Reports issued an erratum to the 2011 paper flagged in the investigation, correcting issues in several figures. Here’s the retraction notice for “The inner centromere–shugoshin network prevents chromosomal instability,” the 2015 paper in Science and the first of the papers to be retracted: Continue reading Authors retract Science paper after investigation reveals manipulated images

SAGE journal retracts three more papers after discovering faked reviews

SAGE recently retracted three 2015 papers from one of its journals after the publisher found the articles were accepted with faked peer reviews. The retraction notices call out the authors responsible for submitting the reviews.

This trio of retractions is the second batch of papers withdrawn by Technology in Cancer Research & Treatment over faked reviews in the past eight months. In 2016, the journal began investigating concerns from an anonymous tipster about faked reviewer reports and subsequently retracted three papers in December over “manipulation of the peer-review process” (1, 2, 3).

Jennifer Lovick, the journal’s executive editor, told us the recent issues have prompted the journal to take steps to strengthen the peer review process: Continue reading SAGE journal retracts three more papers after discovering faked reviews

Genetic disorder gets name change, but patient’s father still not happy

Credit: Online Mendelian Inheritance in Man

The leading genetic disease database has chosen a new name for a genetic condition, following complaints from a man whose son has the condition.

On Aug. 11, 2017, two days after our coverage of the situation, the Online Mendelian Inheritance in Man (OMIM) database changed the primary name of the phenotype associated with mutations in the RPS23 gene. The new name describes a set of features: “Brachycephaly, Trichomegaly, and Developmental Delay,” or BTDD.

Brachycephaly describes a condition where the back of the head is abnormally flat and trichomegaly refers to extra length, curling, pigmentation, or thickness of the eyelashes.

Marc Pieterse, of the Netherlands, has a son with the rare RPS23 mutation, one of two known patients in the world. The mutation affects ribosomes, cell components involved in protein production. On Aug. 9, we reported on Pieterse’s crusade against OMIM’s original name for the condition, which dubbed it a syndrome. He has feared that calling it a syndrome would “stigmatize” his son’s condition and tried to get the paper underpinning the OMIM entry retracted. The American Journal of Human Genetics has said it will not retract the paper.

Continue reading Genetic disorder gets name change, but patient’s father still not happy