Cancer drug paper nulled by “statistical errors”

12032Researchers have pulled a paper about a drug used to treat pancreatic tumors due to “statistical errors.”

The 2014 paper suggested a drug that appears to treat pancreatic tumors also works in Chinese patients. We’re not exactly sure what went wrong with “A randomized phase II study of everolimus for advanced pancreatic neuroendocrine tumors in Chinese patients,” however, because the retraction note is not particularly helpful. Here’s the whole thing, published in Medical Oncology: Continue reading Cancer drug paper nulled by “statistical errors”

Correction “does not change the scientific meaning” of leukemia letter

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The journal Blood has issued a correction in a 2009 letter about the molecular underpinnings of chronic lymphocytic leukemia.

Despite the extent of the changes to a figure, “the error does not change the scientific meaning,” according to the erratum.

The article “p73, miR106b, miR34a, and Itch in chronic lymphocytic leukemia” was written in response to a 2009 Blood paper about the role of a microRNA in CLL. But its western blots were “assembled incorrectly,” leading to duplicated panels. Another set of panels was “shifted.”

So the authors repeated the experiments, and presented them in a correction. Here’s the correction notice in full, published earlier this month, including the figures in question:

Continue reading Correction “does not change the scientific meaning” of leukemia letter

Paper on chemtrails, a favorite subject of conspiracy theorists, retracted

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A paper claiming to expose the “tightly held secret” that long clouds trailing from jets are toxic coal fly ash — and not, as the U.S. government says, primarily composed of harmless ice crystals — has been retracted.

The paper is called “Evidence of Coal-Fly-Ash Toxic Chemical Geoengineering in the Troposphere: Consequences for Public Health,” and was published in the International Journal of Environmental Research and Public Health in August. Author J. Marvin Herndon — a geophysicist, and self-described “independent researcher” — also distributed a press release about the findings.

The abstract explains:

The author presents evidence that toxic coal combustion fly ash is the most likely aerosolized particulate sprayed by tanker-jets for geoengineering, weather-modification and climate-modification purposes and describes some of the multifold consequences on public health.

The detailed retraction note, authored by the academic editor of the paper, Paul B. Tchounwou, a biologist at Jackson State University, points out some errors with the science, and notes that the “language of the paper is often not sufficiently scientifically objective:” Continue reading Paper on chemtrails, a favorite subject of conspiracy theorists, retracted

Three retractions for geriatric medicine researcher

Screen Shot 2015-08-20 at 11.51.11 AMA trio of papers on health issues in elderly patients, all sharing an author, have been retracted from Geriatrics & Gerontology International. 

The reasons for the retractions range from expired kits, an “unattributed overlap” with another paper, “authorship issues,” and issues over sample sizes.

Tomader Taha Abdel Rahman, a researcher at Ain Shams University in Cairo, is the first author on two of the papers, and second author on the third.

Here’s the retraction note for a paper that showed elderly adults with chronic hepatitis C are at risk of having cognitive issues:

Continue reading Three retractions for geriatric medicine researcher

Stem cell researcher Jacob Hanna’s correction count updated to 10

Jacob Hanna
Jacob Hanna

Thanks to some eagle-eyed readers, we’ve been alerted to some corrections for high profile stem cell scientist Jacob Hanna that we had missed, bringing our count to one retraction and 13 errata on 10 papers.

The problems in the work range from duplications of images, to inadvertent deletions in figures, to failures by his co-authors to disclose funding sources or conflicts of interest. Hanna is the first or last author on 4 of the papers, and one of several on the rest.

First up, a correction to a Cell paper on which Hanna is the first author:

Continue reading Stem cell researcher Jacob Hanna’s correction count updated to 10

Retraction of grizzly bear-diabetes study follows departure of Amgen scientist for data manipulation

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The retracted paper made the cover of the August 2014 issue of the journal.

A study that looked to hibernating bears to understand the mechanisms behind diabetes has been retracted because an author based at the biotech company Amgen “manipulated specific experimental data” in two figures.

According to the The Wall Street JournalAmgen discovered the manipulation while reviewing the data following publication of the paper,”Grizzly bears exhibit augmented insulin sensitivity while obese prior to a reversible insulin resistance during hibernation.” Published in Cell Metabolism last year, the paper has been cited 8 times, according to Thomson Scientific’s Web of Knowledge.

A press release from the journal last year — coverage in Science and Nature followed — explained the purpose of the study:

Continue reading Retraction of grizzly bear-diabetes study follows departure of Amgen scientist for data manipulation

Investigation of prominent geneticist Latchman finds “procedural matters,” no misconduct

David Latchman, Birkbeck

An investigation by the University College London has cleared prominent geneticist David Latchman of misconduct, but concluded he has “procedural matters in his lab that required attention.”

Latchman has two retracted paperson PubPeer, there are questions about nearly four dozen more.

The results of the investigation were first reported by the Times Higher Education. We also received a short statement from a UCL spokesperson:

Continue reading Investigation of prominent geneticist Latchman finds “procedural matters,” no misconduct

“Our manuscript unintentionally failed to meet academic and publication standards”

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Authors of a 2014 review paper about the use of “as needed” medications by people with mental health diagnoses are retracting it, but we’re scratching our heads as to why.

The retraction appears in “The experiences of mental health professionals’ and patients’ use of pro re nata (PRN) medication in acute adult mental health care settings: a systematic review protocol of qualitative evidence,” published by The JBI Database of Systematic Reviews and Implementation Reports.

From the abstract of the paper:

Pro re nata is a Latin phrase meaning “for an unforseen need or contingency”…The authors of the systematic review found that although the practice of using “as required” medication is common there is no good evidence of whether this is the best way of helping people to be less agitated when compared to being given a regular dose of medication.

We’re not entirely sure what went wrong here. This is the full contents of the note:

Continue reading “Our manuscript unintentionally failed to meet academic and publication standards”

Three retractions for Oregon neuroscience student investigated by ORI

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Journals have retracted three out of the four papers flagged by the Office of Research Integrity during its investigation of a University of Oregon neuroscience student, David Anderson.

Last month, when we first reported on the case, Anderson told us that he “made an error in judgment,” and took “full responsibility.” Two of the retraction notes say that Anderson “knowingly falsified data,” and cited the Office of Research Integrity case summary.

All three papers focus on memory.

The note for the first retraction, from the  Journal of Experimental Psychology: Human Perception and Performance, reveals exactly how Anderson falsified data in the paper. It’s paywalled — tsk, tsk — but printed here in full:
Continue reading Three retractions for Oregon neuroscience student investigated by ORI

A mess: PLOS mistakenly publishes rejected ADHD-herbicide paper, retracts it

logoPLOS One has retracted a paper that links the most commonly used herbicide to ADHD, after it was “published in error.”

According to the note, the paper was “editorially rejected following peer review and consultation with the Editorial Board,” but ended up going through the production process anyway.

When we contacted the authors, they filled us in with more details.

Continue reading A mess: PLOS mistakenly publishes rejected ADHD-herbicide paper, retracts it