Archive for the ‘cell’ Category
In 2011, a group of researchers at Columbia University reported in Cell that they had been able to convert skin cells from patients with Alzheimer’s disease into functioning neurons — a finding that raised the exciting prospect of “made to order” brain cells for patients with the degenerative disease. As one researcher not involved with the study, led by Asa Abeliovich, put it:
“[This is] simply a remarkable and complete piece of work which will now set a standard for stem cell work in neurological disease. The standard of the characterization of the neuronal cultures is very high,” John Hardy at University College London, U.K., wrote to [Alzforum]. He was not involved in the work but is taking a similar approach in his own lab.
According to the abstract of “Directed Conversion of Alzheimer’s Disease Patient Skin Fibroblasts into Functional Neurons:”
“I am deeply saddened and disturbed:” Co-author of retracted Nature paper reveals how problems came to light
On Wednesday, we reported on a Nature retraction of a paper whose corresponding author had also had a Cell paper retracted, and had been found to have committed a “violation of academic integrity” by Utrecht University. Today, we present the back story of how those retractions came to be, from another co-author of both papers, Ben Scheres, of Wageningen University: Read the rest of this entry »
We have an update on the case of Pankaj Dhonukshe, a scientist about whom we reported in November. Utrecht University has found that Dhonukshe, a former researcher at the Dutch university, committed “a violation of academic integrity” in work that led to a number of papers, including one published in Nature and once since retracted from Cell.
Cell update: Co-corresponding author let go from Belgian university; retraction notice language changed
We’ve learned more about the circumstances behind a Cell retraction that we covered last week.
First, one of the two corresponding authors left the institution where he most recently worked. Belgium’s VIB Ghent told us that Pankaj Dhonukshe was no longer employed there and said: Read the rest of this entry »
The article, “Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK,” came from the lab of Jef Boeke, a celebrated biochemist. But a former lab member, Daniel Yuan, who was fired by Hopkins in late 2011 after 10 years at the institution, had repeatedly raised questions about the validity of the findings. Those concerns eventually made their way into the Washington Post, prompting this response from the university. Read the rest of this entry »
Cell is looking into whether the authors of a widely hailed study published last week claiming to have turned human skin cells into embryonic stem cells manipulated images inappropriately, Retraction Watch has learned.
The potential image problems came to light on PubPeer, a site designed to allow for post-publication peer review. A commenter, identified as Peer1, identified “several examples of image reuse which might be of interest to PubPeer members and readers:” Read the rest of this entry »
Alice Ting, winner of an NIH Directors Pioneer Award and named one of Technology Review’s “Innovators Under 35,” published the paper, “Imaging Activity-Dependent Regulation of Neurexin-Neuroligin Interactions Using trans-Synaptic Enzymatic Biotinylation,” in Cell in 2010 along with Amar Thyagarajan.
One of the things we try to do here at Retraction Watch is keep tabs on retracted work that appears again the literature. We did that twice in one day last year, once with a paper about chimps that was retracted from Biology Letters and ended up in the Journal of Human Evolution, and then again with a PLOS ONE paper on on “longevity genes” that had been retracted from Science.
Today, we have another case. Read the rest of this entry »
The senior author on the paper — there were 22 altogether — is Paul Worley of Johns Hopkins. Here’s the notice for “Enhanced Polyubiquitination of Shank3 and NMDA Receptor in a Mouse Model of Autism:” Read the rest of this entry »