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Retraction Watch

Tracking retractions as a window into the scientific process

Archive for the ‘cell’ Category

Cell retraction of Alzheimer’s study is second for Tufts neuroscientist

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Domnez_Gizem

Gizem Donmez, via Tufts

A researcher at Tufts University has retracted a paper in Cell, a year after retracting a study on a similar subject from the Journal of Biological Chemistry.

Here’s the notice for “SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10,” a 2010 paper by Tufts’ Gizem Donmez, MIT’s Leonard Guarante — of longevity research fame — and colleagues: Read the rest of this entry »

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Written by Ivan Oransky

August 13, 2014 at 8:30 am

Fraud fells Alzheimer’s “made to order” neurons paper in Cell

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cell414In 2011, a group of researchers at Columbia University reported in Cell that they had been able to convert skin cells from patients with Alzheimer’s disease into functioning neurons — a finding that raised the exciting prospect of “made to order” brain cells for patients with the degenerative disease. As one researcher not involved with the study, led by Asa Abeliovich, put it:

“[This is] simply a remarkable and complete piece of work which will now set a standard for stem cell work in neurological disease. The standard of the characterization of the neuronal cultures is very high,” John Hardy at University College London, U.K., wrote to [Alzforum]. He was not involved in the work but is taking a similar approach in his own lab.

According to the abstract of “Directed Conversion of Alzheimer’s Disease Patient Skin Fibroblasts into Functional Neurons:”

Read the rest of this entry »

“I am deeply saddened and disturbed:” Co-author of retracted Nature paper reveals how problems came to light

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Ben Scheres

Ben Scheres

On Wednesday, we reported on a Nature retraction of a paper whose corresponding author had also had a Cell paper retracted, and had been found to have committed a “violation of academic integrity” by Utrecht University. Today, we present the back story of how those retractions came to be, from another co-author of both papers, Ben Scheres, of Wageningen University: Read the rest of this entry »

Utrecht University finds “violation of academic integrity” by former researcher

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dhonukshe

Pankaj Dhonukshe

We have an update on the case of Pankaj Dhonukshe, a scientist about whom we reported in November. Utrecht University has found that Dhonukshe, a former researcher at the Dutch university, committed “a violation of academic integrity” in work that led to a number of papers, including one published in Nature and once since retracted from Cell.

Here’s the university’s statement: Read the rest of this entry »

Written by Ivan Oransky

February 25, 2014 at 12:57 pm

Cell update: Co-corresponding author let go from Belgian university; retraction notice language changed

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cell november 2013We’ve learned more about the circumstances behind a Cell retraction that we covered last week.

First, one of the two corresponding authors left the institution where he most recently worked. Belgium’s VIB Ghent told us that Pankaj Dhonukshe was no longer employed there and said: Read the rest of this entry »

Authors retract Cell paper amid ongoing investigation

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cell november 2013The authors of a 2012 paper in Cell have retracted it after discovering “serious issues with several figures.”

Here’s the notice for “A PLETHORA-Auxin Transcription Module Controls Cell Division Plane Rotation through MAP65 and CLASP:” Read the rest of this entry »

Nature yanks controversial genetics paper whose co-author was found dead in lab in 2012

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naturecover1113Nature has retracted a controversial 2012 paper by a group from Johns Hopkins University which has been the subject of a protracted public dispute.

The article, “Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK,” came from the lab of Jef Boeke,  a celebrated biochemist. But a former lab member, Daniel Yuan, who was fired by Hopkins in late 2011 after 10 years at the institution, had repeatedly raised questions about the validity of the findings. Those concerns eventually made their way into the Washington Post, prompting this response from the university. Read the rest of this entry »

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