Archive for the ‘czech republic’ Category
Several months after a drug company cancelled development of a potential diabetes cure because it found evidence that a biotech they had recently acquired had committed misconduct in studies of the drug, two retractions of relevant studies have appeared.
The research involves DiaPep277, which, as Josh Levy explained here in September, “would cause the immune system to stop attacking beta cells,” the cells in the pancreas that produce insulin. But Hyperion Therapeutics, which had acquired DiaPep277 developer Andromeda Biotech in June, announced in September that it had
uncovered evidence that certain employees of Andromeda Biotech, Ltd., which Hyperion acquired in June 2014, engaged in serious misconduct, including collusion with a third-party biostatistics firm in Israel to improperly receive un-blinded DIA-AID 1 trial data and to use such data in order to manipulate the analyses to obtain a favorable result.
The retractions are both of papers published in Diabetes Care in May 2014. Here’s the notice for “Treatment of Recent-Onset Type 1 Diabetic Patients With DiaPep277: Results of a Double-Blind, Placebo-Controlled, Randomized Phase 3 Trial:” Read the rest of this entry »
Karel Bezouška, a researcher who broke into a lab refrigerator to tamper with an investigation into his work, has nine retractions.
Here’s the retraction notice in Biochemistry for 2010’s “Cooperation between Subunits Is Essential for High-Affinity Binding of N-Acetyl-d-hexosamines to Dimeric Soluble and Dimeric Cellular Forms of Human CD69:” Read the rest of this entry »
Karel Bezouška, the scientist who tried to derail an investigation into his work by breaking into a lab refrigerator has had an eighth paper retracted.
Here’s the notice for “Synthetic N-Acetyl-d-glucosamine Based Fully Branched Tetrasaccharide, a Mimetic of the Endogenous Ligand for CD69, Activates CD69+ Killer Lymphocytes upon Dimerization via a Hydrophilic Flexible Linker:” Read the rest of this entry »
Here’s the notice for “Carboxylated calixarenes bind strongly to CD69 and protect CD69+ killer cells from suicidal cell death induced by tumor cell surface ligands,” which was first published in Bioorganic & Medicinal Chemistry in 2010: Read the rest of this entry »
Here’s the notice from Bioconjugate Chemistry for 2012’s “Dimerization of an Immunoactivating Peptide Derived from Mycobacterial hsp65 Using N-Hydroxysuccinimide Based Bifunctional Reagents Is Critical for Its Antitumor Properties:” Read the rest of this entry »
Karel Bezouška, who, as we noted last year “broke into a lab refrigerator so he could tamper with samples being used to try to replicate the experiments during the investigation,” has had his fourth paper retracted.
Here’s the notice, for “Synthesis of Multivalent Glycoconjugates Containing the Immunoactive LELTE Peptide: Effect of Glycosylation on Cellular Activation and Natural Killing by Human Peripheral Blood Mononuclear Cells,” in the Journal of the American Chemical Society (JACS): Read the rest of this entry »
We’ve found a third retraction for Karel Bezouška, the Czech scientist, who, as we reported this summer, broke into a lab in an attempt to tamper with experiments trying to replicate his own falsified data.
The article, “Molecular Characterization of Binding of Calcium and Carbohydrates by an Early Activation Antigen of Lymphocytes CD69,” had appeared in 2003 in Biochemistry. and has been cited 29 times, according to Thomson Scientific’s Web of Knowledge.
Okay, so it’s not quite Kafka, but a group of forensic geneticists from Prague’s Charles University has lost a paper in Folia Biologica (a journal from that famed institution where Kafka studied) over what appears to be a rather Byzantine dispute about authorship and the quality of the data.
The 2010 article, “DNA analysis of ancient skeletal remains” was written by a trio of authors from Charles University’s Department of Anthropology and Human Genetics. According to its abstract: Read the rest of this entry »
Earlier this month we wrote about the retraction by Nature of a 19-year-old paper by Karel Bezouska, a former star researcher at Prague’s Charles University whose “dangerous and irresponsible deviations” from acceptable practice went as far as tampering with refrigerated samples to cover his tracks.
BMC Biotechnology has retracted another Bezouska paper, this one from 2011. He’s the second author on the article, titled “Heterologous expression, purification and characterization of nitrilase from Aspergillus niger K10.”
The paper, “Static High-Gradient Magnetic Fields Activate Transient Receptor Potential Vanilloid 4 (TRPV4) Ion Channels Enabling Remote Control of Cell Function,” whose corresponding author is Thomas Simmet of Ulm University, appeared online on June 11. Since June 24, the PDF of the paper has been stamped: Read the rest of this entry »