Nobelist Linda Buck retracts two studies on olfactory networks — and the news is embargoed

Well, it’s happened: The Embargo Watch and Retraction Watch worlds have collided. I had initially figured on two posts here, but it soon became clear that how journals were handling these retractions, using embargoes, was central to both. So this is being cross-posted on both blogs.

Linda Buck, who shared the 2004 Nobel Prize in Physiology or Medicine, has retracted two papers published in 2005 and 2006. Both retractions — one in the Proceedings of the National Academy of Sciences (PNAS) and one in Science — appear online today.

The papers describe how nerves that carry information about scents connect from the nose to the olfactory bulb, where they are processed. They were published after the 2004 Nobel, which was for discoveries “of odorant receptors and the organization of the olfactory system.”

The retractions come two and a half years after Buck retracted a 2001 Nature paper co-authored with Zhihua Zou, a post-doc in her then-Harvard lab. She’s been at the Fred Hutchinson Cancer Research Center since 2002, and is a Howard Hughes Medical Institute investigator. In 2008, Nature’s news section reported:

Harvard Medical School has formed an ad hoc committee to review the retraction, and Buck has asked the Fred Hutchinson Cancer Research Center to review two later publications on which Zou was the lead author. “It’s disappointing of course,” says Buck. “The important thing is to correct the literature.”

The PNAS and Science retractions are of those two later publications. The PNAS study was cited 61 times, and the Science study was cited 73 times, according to the Thomson Scientific Web of Knowledge.

The Science retraction reads: Continue reading Nobelist Linda Buck retracts two studies on olfactory networks — and the news is embargoed

Gene therapy researcher Savio Woo retracts two more papers

courtesy Mount Sinai School of Medicine

Mount Sinai School of Medicine researcher Savio Woo, whom Retraction Watch reported last week has already retracted four papers from major journals as two postdocs have been fired from his lab, has retracted two more from Molecular Therapy: The Journal of the American Society of Gene Therapy.

The two papers, both from 2007, were Continue reading Gene therapy researcher Savio Woo retracts two more papers

Best Of Retractions, Part I: Water, water, everywhere, except in “Historical Palestine,” aka Israel

Although Retraction Watch might have been born just before yesterday, we find it instructive to look back in time for items we would have covered had we been around a bit longer. We’ll do this periodically to generate a “Best Of” collection of retractions that catch our eye both for what they might suggest about scientific publishing and for good old-fashioned  interest. Here’s the first installment:

A furtive attempt to play politics with a galley proof led to the retraction of a paper on Middle East water policy a few months ago. The article, “Optimizing irrigation water use in the West Bank, Palestine,” appeared in the February 2010 issue of Agricultural Water Management, an Elsevier journal. Written by Palestinian and Dutch researchers, the article modeled various scenarios of water and crop policies in the West Bank in an effort to determine the most efficient use of resources.

But a funny thing happened on the way to the printer. The authors decided to make a political protest of sorts in the galleys, a ham-handed gesture that led to the retraction of the paper, as the journal explained in a note: Continue reading Best Of Retractions, Part I: Water, water, everywhere, except in “Historical Palestine,” aka Israel

Progressive: How the Cochrane Library handles updates-in-progress

Over the summer, while searching for some studies and evidence for various treatments, my wife, a television writer and producer, noticed something she thought unusual enough to flag for me. The titles of a number of Cochrane Library reviews started with “WITHDRAWN.”

The Cochrane Library is the world’s leading publisher of systematic reviews, which gather all of the high-quality evidence on a given subject and offer a rigorous analysis of whether a given test or treatment works. It’s an invaluable resource. (Shameless plug: Join the Association of Health Care Journalists, where I’m treasurer, and access to the $285-per-year Cochrane subscription is included.)

Retraction Watch was curious about what “WITHDRAWN” meant, since “withdrawal” is often used synonymously with retraction. Cochrane updates its reviews regularly, as new evidence surfaces, of course. But these abstracts didn’t say anything about new reviews.

We asked Jen Beal, who handles media relations for Wiley, the Cochrane Library’s publisher. She responded: Continue reading Progressive: How the Cochrane Library handles updates-in-progress

Update on gene therapy researcher Savio Woo retractions: Two post-docs dismissed for fraud

More on the case of Savio Woo, the New York gene therapy researcher who, as Retraction Watch reported  this week, had several papers pulled by noted journals.

Two of Woo’s post-doctoral fellows at Mount Sinai School of Medicine were dismissed for “research misconduct,” said Ian Michaels, a spokesman for the institution. According to Michaels:

When Dr. Savio L C Woo came to suspect that two post-doctoral fellows in his laboratory may have engaged in research misconduct he notified the Mount Sinai Research Integrity Office. Mount Sinai immediately initiated institutional reviews that resulted in both post-doctoral fellows being dismissed for research misconduct. At no time were there allegations that Dr. Woo had engaged in research misconduct. As part of its review, the investigation committee looked into this possibility and confirmed that no research misconduct could be attributed to Dr. Woo, who voluntarily retracted the papers regarding the research in question. Mount Sinai reported the results of its investigations to the appropriate government agencies and continues to cooperate with them as part of its commitment to adhere to the highest standards for research integrity.

We have plenty of other questions for Mount Sinai about the details of the investigation—including when the post-docs were let go, which Michaels declined to answer—and will update when we learn more.

Work from noted gene therapy researcher Savio Woo under scrutiny with slew of retractions

Research from the lab of Savio Woo, a leading U.S. gene therapy scientist, has come into question with the retraction by major journals of at least four of his articles.

The papers, which appeared in the Proceedings of the National Academy of Sciences, the Journal of the National Cancer Institute and Human Gene Therapy, involve findings published between 2005 and 2009, address various aspect of gene therapy. Two of the articles boasted of potential breakthroughs, and even a possible cure, for diseases with extremely high rates of mortality.

The study in JNCI, for example, reported the finding of a genetically modified bacterium that showed promise for the treatment of pancreatic cancer, a particularly lethal malignancy, and other tumor types. Another, published in 2005 in PNAS, claimed to have discovered a possible cure for phenylketonuria, or PKU, in mice—a finding that was cited more than 30 times and trumpeted in the media.

However, in a retraction notice issued this month, Woo wrote that: Continue reading Work from noted gene therapy researcher Savio Woo under scrutiny with slew of retractions

What happens after a retraction for falsified data? An example from Endocrinology

In the world of scientific misconduct, it’s often worth keeping track of what happens to scientists whose papers were retracted because of falsified or otherwise fraudulent results.

Take the case of Hung-Shu Chang. Last week, the the federal Office of Research Integrity announced that it had closed its investigation into the scientist’s misdeeds. Chang was a visiting postdoctoral researcher from Taiwan who in 2005 had come to the renowned Skinner Laboratory at Washington State University to study the effects of endocrine disruptors — a class of compounds that includes BPA and which have been shown to disrupt the action of hormones — on sex cells.

Chang was accused of falsifying data in a 2006 paper in Endocrinology — later retracted — reporting the damaging effects of vinclozolin, a fungicide used to protect vineyards, on the genetic integrity of sperm cells.

According to federal and university investigators, Chang, who has since returned to Taiwan, “fabricated and falsified data” central to the authors’ claim that vinclozolin could alter sperm in such a way that the mutations could cause disease in future generations. Such mutations are referred to as epigenetic changes. Continue reading What happens after a retraction for falsified data? An example from Endocrinology

Update on stem cell-cancer link retraction: Why not everyone signed, and why authors ended up in another journal first

Last month, we wrote about the retraction of a 2005 paper suggesting that some adult stem cells might give rise to cancer. That, of course, would be a problem if researchers tried treating heart disease and other conditions with them. The paper’s authors retracted it, however, when it became clear that instead of being transformed — that’s the scientific word for “became cancerous” — the cells had simply become contaminated and overgrown with tumor cells used in research.

We had some questions for the authors of the original paper, and for the editor of the journal. Last week, we heard back from one of the paper’s authors, Javier Garcia-Castro, who had been on vacation without Internet access for weeks. In an email to Retraction Watch, Garcia-Castro wrote: Continue reading Update on stem cell-cancer link retraction: Why not everyone signed, and why authors ended up in another journal first

Missing authors: Journal retracts article showing stinky dairy products make good mosquito bait

Citing “authorship” issues, a parasitology journal has retracted a paper by a Kenyan scientist which showed that Limburger cheese and milk cream may be effective mosquito bait.

The paper, by Eunice Owino, of the University of Nairobi, was published online in Parasites & Vectors this June but retracted in late August after the editors quickly learned that Owino had neglected to list several other authors on her manuscript.

According to Chris Arme, a parasitologist and editor-in-chief of the journal, the article began to smell like Lim … well, you know, immediately: Continue reading Missing authors: Journal retracts article showing stinky dairy products make good mosquito bait

Update: German university investigating authors who retracted caffeine-liver fibrosis letter

Yesterday we reported on a retraction in a European liver journal involving post-acceptance shenanigans by a group of German researchers including a father and son, Axel and Olav Gressner. Well, it turns out there’s a bit more there there.

Didier Samuel, editor-in-chief of the Journal of Hepatology, where the team’s letter to the editor was retracted, tells Retraction Watch he was contacted earlier this year by the University of Aachen. The university was investigating potential misconduct by Olav Gressner. The journal launched its own inquiry, leading to the retracted letter, Samuel says.

Samuel’s journal has not pulled any other papers from the Gressners. However, the group “is not encouraged to submit to our journal” in the future, he says. Although the lab has claimed that “typewritten errors” were to blame for the alerted manuscript, Samuels says, “the editors were not convinced” of this explanation. Continue reading Update: German university investigating authors who retracted caffeine-liver fibrosis letter