Is misconduct more likely in drug trials than in other biomedical research?

A new paper by Chicago pharmacy researchers suggests that researchers performing drug studies are more likely to commit fraud than are their colleagues in the rest of biomedicine.

In the paper, “Retraction Publications in the Drug Literature,” which appears in Pharmacotherapy, Jennifer C. Samp, Glen T. Schumock, and A. Simon Pickard take a look at previous studies of retractions, including those by Grant Steen and John Budd, both of whose work we’ve covered. They also identify 742 retractions in the biomedical literature from 2000 to 2011, 102 of which were of drug studies, to analyze.

Noting the growing interest in retractions, they write that Continue reading Is misconduct more likely in drug trials than in other biomedical research?

Journal retracts protein paper from scientist who misused deceased mentor’s data

It seemed like a touching tribute when Jiasheng Diao dedicated his 2009 article, “Crystal Structure of Butyrate Kinase 2 from Thermotoga maritima, a Member of the ASKHA Superfamily of Phosphotransferases,” in the Journal of Bacteriology to a deceased mentor, Miriam Hasson.

Before her death in January 2006, of a brain tumor, Hasson and her husband, David Sanders, made up a power-team of protein researchers at Purdue.

Hasson was an X-ray crystallographer while Sanders is a biochemist, and together they would map out the structure and function of proteins. One of their projects  was a  collaboration funded by a grant to Sanders from the National Science Foundation. By the time Diao joined, the effort had already led to butyrate-kinase crystals — albeit of poor quality, Sanders said.

When Hasson died, Sanders — with his institution’s blessing — took control of her data. That made sense, since their labs had collaborated closely. Indeed, they occasionally shared post-docs, including Diao, who had started with Hasson on a project looking at a protein called butyrate kinase but then moved over to Sanders’ lab as the work evolved. Continue reading Journal retracts protein paper from scientist who misused deceased mentor’s data

Fujii retractions mount

Spring is a time of rebirth and renewal — and, if you are Yoshitaka Fujii, retraction.

We have seen retraction notices in two journals concerning papers by Fujii, the Japanese anesthesiologist who, according to an international group of editors, may ultimately lose some 190 publications to research fraud.

Otoloaryngology — Head and Neck Surgery last month had the following notice for a 2011 article titled “Antiemetic Efficacy of Low-Dose Midazolam in Patients Undergoing Thyroidectomy,” by Fujii and an M. Ikatura (who has not been accused of wrongdoing, as far as we know): Continue reading Fujii retractions mount

Brit psych journal retracts Stapel paper on the paradox of failure

In 2011, Diederik Stapel, a Dutch researcher who at the time was a shining star in the world of social psychology, published an article in the British Journal of Social Psychology with the counter-intuitive claim that failure can sometimes be more emotionally gratifying than success.

We’re guessing this isn’t one of those times. As readers of this blog well know, Stapel has admitted to fabricating loads of data. The BJSP has now retracted the article.

Here’s the notice for the paper, which has yet to be cited, according to Thomson Scientific’s Web of Knowledge: Continue reading Brit psych journal retracts Stapel paper on the paradox of failure

Skin in the game: Derm journal retracts identical cancer case study submitted by two groups at the same facility

It seems the faculty at Myongji Hospital, in Goyang, Korea, have some ‘splainin to do.

Two groups of physicians from the hospital, part of Kwandong University College of Medicine, published case reports on a rare form of basal cell carcinoma. Turns out they were writing about the same patient.

According to a retraction notice in the Annals of Dermatology, a publication of the Korean Dermatological Association and the Korean Society for Investigative Dermatology: Continue reading Skin in the game: Derm journal retracts identical cancer case study submitted by two groups at the same facility

Will a new literature format “radically alter” how scientists write, review, and read papers?

A group of authors at a Pittsburgh company have proposed a new way to write, review, and read scientific papers that they claim will “radically alter the creation and use of credible knowledge for the benefit of society.”

From the abstract of a paper appearing in the new Mary Liebert journal Disruptive Science and Technology, which, according to a press release, will “publish out-of-the-box concepts that will improve the way we live”: Continue reading Will a new literature format “radically alter” how scientists write, review, and read papers?

Would you pay $63 for a retraction notice?

For $63 plus tax, you can have a single steak with a side order of fried potatoes and a wedge of crisp iceberg lettuce at the famed Peter Luger steakhouse in Brooklyn. Or you can get a peek at one measly retraction notice from Bentham Science Publishers (at least it’s BYOB).

To be fair, the publisher, based in the United Arab Emirates, does offer a free version of the notice on its own website. But Bentham uses the company Ingenta Connect as a go-between to collect fees —  some of which reach $100 per article, according to a company employee — and as far as we can tell, no such gratis access is available through the middleman. Neither does Ingenta direct readers to the free version in its landing page for the notice.

The article in question, “Solubilization and Amorphization of Non Steroidal Anti-Inflammatory Drug with Low Molecular Weight Chitosan for a New Guar-Based Colon Delivery Formulation,” by Kadria A. Elkhodairy, Nahla S. Barakat and Fars K. Alanazi, appeared in the March 2011 issue of Letters in Drug Design & Discovery. The retraction notice reads: Continue reading Would you pay $63 for a retraction notice?

Retraction seven for Shouwei Han, this one in the American Journal of Physiology

ShouWei Han, who has been forced to retract six papers from various physiology journals following an investigation into his work by his former employer, the University of Louisville, has added another one to his tally.

Here’s the notice, from the American Journal of Physiology: Lung Cellular and Molecular Physiology: Continue reading Retraction seven for Shouwei Han, this one in the American Journal of Physiology

Weight loss surgeon who made up data loses job at University Hospital Leipzig

Edward Shang

Edward Shang, a weight loss surgeon who has now retracted two papers for fraudulent data, is out of his job at the University Hospital Leipzig.

According to a university release — which was apparently retracted for about an hour and which we’ve had trouble accessing at various points this morning — Shang’s employment contract with the Leipzig hospital is “terminated by mutual agreement with immediate effect.”

The release also says Continue reading Weight loss surgeon who made up data loses job at University Hospital Leipzig

Fleetwood Mac, anyone? Landslides paper crumbles under weight of “significant originality issue”

As Stevie Nicks sang in Fleetwood Mac’s hit, “Landslide”:

Well, I’ve been afraid of changing, cause I’ve built my life around you ….

The authors of a 2010 paper in the journal Landslides might have taken those words a little too much to heart. Their manuscript, “Real-time slope water table forecasting by multi-tank model combined with dual ensemble Kalman filter,” purported to be an original paper — but it was really “Second Hand News,” to quote more Fleetwood Mac, the kind that might have “Murrow Turning Over in His Grave.”

According to the notice: Continue reading Fleetwood Mac, anyone? Landslides paper crumbles under weight of “significant originality issue”