ORI finds Parkinson’s-pesticides researcher guilty of faking data; two papers to be retracted

The U.S. Office of Research Integrity (ORI) has found that a neuroscientist who studied the effects of pesticides on a mouse model of Parkinson’s disease made up data.

As The Scientist reported on Friday, the ORI found that Mona Thiruchelvam faked cell counts in two grant applications and a number of papers that claimed to show how the pesticides paraquat, maneb, and atrazine might affect parts of the brain involved in Parkinson’s. The Scientist notes: Continue reading ORI finds Parkinson’s-pesticides researcher guilty of faking data; two papers to be retracted

Report: Fujii faked data in at least 172 papers

A Japanese web site is reporting that Yoshitaka Fujii, a Japanese anesthesiologist suspected of widespread data fabrication, did indeed fake his results in at least 172 published studies.

According to the article, on a site called Jiji Press: Continue reading Report: Fujii faked data in at least 172 papers

Authors retract PLoS Medicine foreign health aid paper that had criticized earlier Lancet study

On May 8, PLoS Medicine published a paper by Rajaie Batniji and Eran Bendavid of Stanford University, about “whether development assistance for health provided to developing country governments increases health expenditures.”

That paper caught the eye of the Center for Global Development’s David Roodman. He began a May 14 blog post about the study, “The Health Aid Fungibility Debate: Don’t Believe Either Side,” as follows: Continue reading Authors retract PLoS Medicine foreign health aid paper that had criticized earlier Lancet study

Withdraw that emotion: Psych journal retracts two Stapel papers on mood

Two more papers from Dutch fraudster Diederik Stapel have been retracted. Both appeared in the journal Psychological Science in 2008, with the same, evidently unwitting co-author, Kirsten Ruys, of Tilburg University.

Here is the notice: Continue reading Withdraw that emotion: Psych journal retracts two Stapel papers on mood

Reverse tissue engineering: data reuse causes retractions of three papers from German organ researchers

The body count has reached three for a group of German tissue engineers who appear to have cloned their data in many of their publications.

Tissue Engineering Part A has retracted one of the papers from the investigators, titled “Clinically established hemostatic scaffold (tissue fleece) as biomatrix in tissue- and organ-engineering research,” which was published in 2003.

The notice states: Continue reading Reverse tissue engineering: data reuse causes retractions of three papers from German organ researchers

Controversial paper on life-extending buckyballs corrected after blog readers note problems

Back in April, a group of French and Tunisian researchers published a paper in Biomaterials which came to the astonishing conclusion that buckyballs (carbon tetrachloride) coated in olive oil could dramatically extend the lives of lab rodents. That news was picked up by Derek Lowe’s In the Pipeline blog, on which he expressed some bemusement about the work but ultimately praised it:

These are reasonable (but unproven) hypotheses, and I very much look forward to seeing this work followed up to see some more light shed on them. The whole life-extension result needs to be confirmed as well, and in other species. I congratulate the authors of this work, though, for giving me the most number of raised eyebrows I’ve had while reading a scientific paper in quite some time.

One of those eyebrows dropped a bit the following day, when Lowe reported that readers had pointed him to a clear case of image duplication in the article. At the time, Lowe concluded: Continue reading Controversial paper on life-extending buckyballs corrected after blog readers note problems

Wham, bam, no thank you, ram: Publisher error leads to retraction of already-withdrawn sheep sperm paper

Caution: Sexual innuendo ahead.

The withdrawal method is a notoriously unreliable form of birth control. It seems that what happens between the sheets applies to paper as well as cotton.

Here’s a retraction notice from BMC Research Notes that speaks — and nudges and winks — for itself. The 2011 article, “Effect of controlled and uncontrolled cooling rate on motility parameters of cryopreserved ram spermatozoa,” by a team of Irani veterinary scientists: Continue reading Wham, bam, no thank you, ram: Publisher error leads to retraction of already-withdrawn sheep sperm paper

So what should happen to scientific papers that are proven wrong?

There’s been a lively discussion at Jeff Perkel’s guest post from this morning, “Should Linus Pauling’s erroneous 1953 model of DNA be retracted?” Most of our commenters say “no.” Some of those “nos” are quite emphatic, suggesting that Retraction Watch should brush up on epistemology, or that this was a silly question to begin with.

We appreciate all the feedback, of course, and thought this would be a good opportunity to expand the answers a bit from “yes” and “no” — which a few commenters have begun doing. So we’re posting this poll about what should happen to papers such as Pauling’s that are proven to be wrong, knowing that they continue to be cited as if they had no significant flaws. (Pauling’s, as Perkel pointed out, was actually wrong about at least one thing even when it was published, but leave that aside for these purposes.) Vote here: Continue reading So what should happen to scientific papers that are proven wrong?

Should Linus Pauling’s erroneous 1953 model of DNA be retracted?

Linus Pauling, via Wikimedia

We love history at Retraction Watch, but with few exceptions, such as covering what seems to have been the first-ever English language retraction in 1756, the daily march of retractions doesn’t leave us much time to take steps back. So we’re very glad to be able to present a guest post by our friend Jeff Perkel about a classic paper that scientists have known to be wrong for most of its nearly 60-year-life — and yet remains in the literature.

The date is December 31, 1952. Linus Pauling, the CalTech wunder-chemist who had recently solved the secondary structure of proteins by describing the alpha-helix and the beta-sheet, has just submitted a “Proposed Structure for the Nucleic Acids” to the Proceedings of the National Academy of Sciences. The PNAS description appears in February 1953 and runs for 14 pages, with seven figures and two tables (compare that with Watson and Crick’s one-pager two months later in Nature).

Pauling also submitted a short note to Nature to alert that journal’s readers to the basics of the PNAS paper. The Nature note appeared in the journal’s February 21 issue: Continue reading Should Linus Pauling’s erroneous 1953 model of DNA be retracted?

Is post-hoc statistical analysis the new fraud detection tool? A new review looks at fraudster Reuben’s work

In the beginning, there was Scott Reuben.

Well, not quite. Reuben, a Massachusetts anesthesiologist who fabricated data and briefly topped our list of most-retracted authors, didn’t invent research fraud, although he did spend six months in federal prison for his crimes. But his case was in no small measure responsible for the birth of this blog, and, well, the rest of human history that followed.

Although Reuben’s retractions are behind him now — his count ends at 22 — and other scientists, including two anesthesiologists, Joachim Boldt and Yoshitaka Fujii, have or likely soon will dramatically eclipsed his mark, a new paper has revisited his publications with an eye toward seeing if they could identify statistical evidence of data manipulation. It’s the same  kind of effort that Ed Yong highlighted as noteworthy about the Dirk Smeesters case, which we covered yesterday and which involved an anonymous statistically inclined whistleblower.

Before we get to whether there was evidence of such manipulation Continue reading Is post-hoc statistical analysis the new fraud detection tool? A new review looks at fraudster Reuben’s work