Don’t perform heart surgery described in retracted paper, says editor

Screen Shot 2016-02-08 at 10.53.50 PMA journal is retracting a paper about a heart surgery technique after discovering the researchers did not have ethics approval to perform a the procedure on 130 patients. What’s more, the local cardiac surgical society had asked the first author to stop using the method in 2004, six years before the study was complete.

The patients in the study had atrial septal defects — a congenital hole in their hearts that allows blood to leak between chambers. The retraction note concludes with the editor in chief advising other surgeons to not use the method to close the hole described in the retracted article, “Long-term assay of off-pump atrial septal defect closure using vena caval inflow occlusion and minimally invasive approaches in 130 cases.

A concern from a reader unraveled the paper. The retraction note explains how:

Continue reading Don’t perform heart surgery described in retracted paper, says editor

Why publishing negative findings is hard

Jean-Luc Margot
Jean-Luc Margot

When a researcher encountered two papers that suggested moonlight has biological effects — on both plants and humans — he took a second look at the data, and came to different conclusions. That was the easy part — getting the word out about his negative findings, however, was much more difficult.

When Jean-Luc Margot, a professor in the departments of Earth, Planetary & Space Sciences and Physics & Astronomy at the University of California, Los Angeles, tried to submit his reanalysis to the journals that published the original papers, both rejected it; after multiple attempts, his work ended up in different publications.

Disagreements are common but crucial in science; like they say, friction makes fire. Journals are inherently disinterested in negative findings — but should it take more than a year, in one instance, to publish an alternative interpretation to somewhat speculative findings that, at first glance, seem difficult to believe? Especially when they contain such obvious methodological issues such as presenting only a handful of data points linking biological activity to the full moon, or ignore significant confounders?

Margot did not expect to have such a difficult experience with the journals — including Biology Letters, which published the study suggesting that a plant relied on the full moon to survive: Continue reading Why publishing negative findings is hard

Paper on alleged – and paradoxical – health benefits of obesity pulled for plagiarism

cancer causes and controlAn article that suggested there is no benefit to being overweight among cancer survivors – the so-called “obesity paradox” – is being retracted for plagiarizing large sections from another paper that explored the same topic in cardiovascular disease.

The journal Cancer Causes & Control pulled the 2014 article last June after determining it contained “large portions” of text from another paper in Preventive Medicine by a different set of authors, which suggested that evidence linking obesity to health benefits in cardiovascular disease may stem from a form of selection bias.

Here’s more from the retraction note: Continue reading Paper on alleged – and paradoxical – health benefits of obesity pulled for plagiarism

Macchiarini defends ethics of 2011 Lancet paper

Paolo Macchiarini
Paolo Macchiarini

Embattled trachea surgeon Paolo Macchiarini, who has spent more than a year fighting misconduct allegations, is defending the ethical oversight behind one of his seminal papers published in The Lancet.

The 2011 paper “Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept study” described a first-of-its-kind procedure: A 36-year-old man with recurrent tracheal cancer received an artificial airway seeded with his own stem cells. The news launched Macchiarini into the stratosphere. And then the questions came. Continue reading Macchiarini defends ethics of 2011 Lancet paper

Court dismisses lawsuit by XMRV-chronic fatigue syndrome researcher

mikovitsA California court has dismissed virologist Judy Mikovits’s lawsuit against fourteen people and two Nevada corporations, in part because she failed to submit necessary documents on time.

Mikovits is the author on a now-retracted Science paper suggesting a link between a virus known as XMRV and chronic fatigue syndrome, which has no known cause. She alleged that she was fired from the Whittemore-Peterson Institute for blowing the whistle on her former colleague’s activities, and that the defendants then colluded to imprison and defame her.

The court dismissed her case last Wednesday. According to the court minutes,

Author dispute, “considerable overlap” retract chemistry study

Spectrochimica Acta Part A- Molecular and Biomolecular Spectroscopy

A chemistry journal has issued a retraction after “a thorough and time-consuming analysis” revealed two out of four authors did not agree to submitting an article published in May, which also contains “considerable overlap and redundancy” with another paper published a few weeks prior in a different journal.

Shortly after the paper appeared in Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, the journal was told “that parts of the manuscript were reused” from an article in the Journal of the Taiwan Institute of Chemical Engineers that was published online March 16. That led to the investigation, and the discovery of the additional authorship issues.

Here’s the full notice: Continue reading Author dispute, “considerable overlap” retract chemistry study

Seralini paper released by predatory publisher is plagiarized by predatory journal

ijtra-logoA 2012 paper co-authored by Gilles Seralini, who has published controversial research showing the dangers of genetically modified foods, has been plagiarized by another researcher.

The 2016 paper, published in the International Journal of Technical Research and Applications, has not been retracted, but the text comparison is fairly obvious.

It’s a case of intra-predatory crime: the International Journal of Technical Research and Applications is on the list of predatory journals compiled by Jeffrey Beall, and the Seralini paper appeared in the Journal of Environmental Protection, which is published by Scientific Research Publishing, which Beall considers to be a predatory publisher.

Here’s the abstract from Seralini’s 2012 paper, “Glyphosate Exposure in a Farmer’s Family:” Continue reading Seralini paper released by predatory publisher is plagiarized by predatory journal

Journal temporarily removes paper linking HPV vaccine to behavioral issues

1-s2.0-S0264410X16X00084-cov150hThe editor in chief of Vaccine has removed a paper suggesting a human papillomavirus (HPV) vaccine can trigger behavioral changes in mice.

The note doesn’t provide any reason for the withdrawal, although authors were told the editor asked for further review.

Two co-authors on the paper — about Gardasil, a vaccine against HPV — have previously suggested that aluminum in vaccines is linked to autism, in research a World Health Organization advisory body concluded was “seriously flawed.”

Approximately 80 million doses of Gardasil were administered in the U.S. between 2006 and 2015. Both the the WHO and the Centers for Disease Control and Prevention have ruled the vaccine to be safe — the CDC, for instance, calls it “safe, effective, and recommended.”

The journal published an uncorrected proof of “Behavioral abnormalities in young female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil” online on January 9th, 2016. In its place now is a note that says:

Continue reading Journal temporarily removes paper linking HPV vaccine to behavioral issues

8th retraction appears for researcher who faked patient records

S00219150An 8th paper has been retracted for Anna Ahimastos, a heart researcher who faked patient records.

It’s the last in a chain of retractions that were the result of an investigation by her former workplace, Baker IDI Heart & Diabetes Institute in Australia. As with the others, she did not agree to the retraction.

The investigation found fabricated patients records in some papers; in other papers, such as the newly retracted 2010 study in Atherosclerosis, the original data source could not be verified.  The latest retraction — “A role for plasma transforming growth factor-β and matrix metalloproteinases in aortic aneurysm surveillance in Marfan syndrome?” — followed up on a previous clinical trial, examining how a blood pressure drug might help patients with a life-threatening genetic disorder.

That previous trial — which also included 17 patients with Marfan syndrome treated with either placebo or perindopril — has been retracted from JAMA; the New England Journal of Medicine has also retracted a related letter.

The latest retraction note conveys similar information to the other perindopril/Marfan syndrome retractions: Continue reading 8th retraction appears for researcher who faked patient records

Johns Hopkins investigation leads to retraction of two lung papers, one highly cited

showCoverImageAn investigation at Johns Hopkins University has uncovered several issues with the figures in two papers on a lung disease linked to smoking, one of which is highly cited.

The American Journal of Respiratory and Critical Care Medicine is retracting both papers, which examine the role of protein NRF2 in chronic obstructive pulmonary disease. But both contain spliced and duplicated figures, among other issues.

Both papers — which share a total of five authors — received an expression of concern in 2014, after the corresponding author noticed anomalies in the figures. That same year, PubPeer commenters had begun raising questions about some of the figures in one of the papers.

A spokesperson for Johns Hopkins declined to say whether the investigation considered if the errors were the result of misconduct.

All authors agreed with the retraction, except for one who couldn’t be located. Here’s more from the retraction note for both papers:

Continue reading Johns Hopkins investigation leads to retraction of two lung papers, one highly cited