Data fabrication by ex-Harvard researcher takes down paper on Huntington’s disease

A researcher at Harvard Medical School and Massachusetts General Hospital is retracting a paper due to “inappropriate manipulation and fabrication of data” by the first author.

According to the retraction notice, published Aug. 22, corresponding author Marian DiFiglia is retracting the paper because the alleged misconduct by the first author, Antonio Valencia:

led to an incorrect conclusion in the paper that NADPH activity is elevated in Huntington’s disease (HD). Some original data were missing and efforts to replicate findings using the reported method or an alternative approach were unsuccessful. An institutional faculty panel supports the decision and the reasons for the retraction.

The notice added that the alleged data manipulation and fabrication affected bar graphs in two of the paper’s figures.

Terri Ogan, a spokesperson for Mass General, told Retraction Watch that Valencia no longer works at the institution, but declined to say whether there has been an investigation into the alleged misconduct: Continue reading Data fabrication by ex-Harvard researcher takes down paper on Huntington’s disease

Authors retract Science paper after investigation reveals manipulated images

Researchers at a prominent Japanese university have retracted a 2015 paper in Science, after an investigation uncovered image falsification and fabrication.

Last September, the University of Tokyo began an investigation of seven papers from the lab of cell biologist Yoshinori Watanabe after receiving anonymous allegations. In May 2017, the university determined that five papers contained falsified or fabricated images, and announced the results of its investigation on August 1. Two of the papers were published in Science, two in Nature and one in EMBO Reports.

On July 1 2017, EMBO Reports issued an erratum to the 2011 paper flagged in the investigation, correcting issues in several figures. Here’s the retraction notice for “The inner centromere–shugoshin network prevents chromosomal instability,” the 2015 paper in Science and the first of the papers to be retracted: Continue reading Authors retract Science paper after investigation reveals manipulated images

Amid legal battle, psych journal issuing caution about torture paper

A psychology journal plans to issue an editor’s note about a controversial paper exploring what the author called “the biggest scandal to hit” the American Psychological Association (APA) in years.

The note cautions readers that the subject of the paper, published in the SAGE journal Teaching of Psychology, is part of a pending lawsuit, and that “teachers considering using the article in their classrooms” should watch for developments in the case.   Continue reading Amid legal battle, psych journal issuing caution about torture paper

“Scientifically misleading errors” prompt authors to withdraw paper

A group of authors have withdrawn a paper after revealing a litany of issues to the journal that published it. Among those issues were “scientifically misleading errors,” “insufficient” validation, and a disagreement between the researchers on whether it should have been published at all.

“Optimal DNA structure of reverse-hairpin beacons for label-free and positive surface enhanced Raman scattering assays,” originally published in June in Optical Materials Express (OMEx), was retracted Aug. 7. The paper purported to describe a detection method for RNA associated with influenza virus. It has not yet been cited, according to Clarivate Analytics’ Web of Science.

Here’s the full list of issues cited in the retraction notice: Continue reading “Scientifically misleading errors” prompt authors to withdraw paper

Weekend reads: Publishing too much?; CRISPR doubts; Pharma in predatory journals

The week at Retraction Watch featured the retraction of a paper from Yale on ketamine and depression, a retraction for Carlo Croce, and a discussion of when a citation may not be enough. Here’s what was happening elsewhere: Continue reading Weekend reads: Publishing too much?; CRISPR doubts; Pharma in predatory journals

Bogus affiliation scuttles paper on Atlantic currents

An oceanography journal has retracted a 2017 paper by a group of researchers in China after learning from a reader that one of the authors had a bogus affiliation in the United States.

The paper, “Southward migrations of the Atlantic Equatorial Currents during the Younger Dryas,” appeared in early spring in Limnology and Oceanography, a publication of the Association for the Sciences of Limnology and Oceanography (limnology is the study of fresh-water bodies). It had three authors: one from Shanghai, one from Wuhan and one, a Chaoyang Zhang, identified as being on the faculty of the Georgia Institute of Technology (otherwise known as Georgia Tech). But that last part was false — no Chaoyang Zhang works at Georgia Tech.

Alarm bells sounded, the journal investigated and turned up other reasons to be concerned about the paper. According to the notice, which it sent to the entire association (more on that in a moment):  Continue reading Bogus affiliation scuttles paper on Atlantic currents

PNAS retracts paper linked to ex-Ohio State researcher who had chemistry PhD revoked

Researchers from The Ohio State University and The Scripps Research Institute are retracting a 2013 paper in Proceedings of the National Academy of Sciences after they uncovered data irregularities.

The retraction notice for “Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation,” will appear online on Sept. 5. The paper purported to find clues about what makes antibodies stable at different temperatures. In a press release issued at the time of publication, corresponding author Thomas Magliery, of The Ohio State University, said the paper might help pharmaceutical companies make better antibody-based drugs. It has been cited 36 times, according to Clarivate Analytics’ Web of Science.

At some point — we’re not exactly sure when — the authors discovered that the antibody stability data was suspect. According to the notice: Continue reading PNAS retracts paper linked to ex-Ohio State researcher who had chemistry PhD revoked

Journal flags four papers by researcher in Spain over figure issues noted on PubPeer

A journal has issued expression of concerns (EOCs) for four papers after a concerned reader notified the editors of issues in several figures.

According to the EOCs, the Journal of Cell Science (JCS) discussed the concerns with the corresponding author, José Ignacio Rodriguez-Crespo, and subsequently notified his institution, Complutense University of Madrid. Last year, all four papers were questioned on PubPeer (1, 2, 3, 4).

The journal’s executive editor, Sharon Ahmad, told us: Continue reading Journal flags four papers by researcher in Spain over figure issues noted on PubPeer

Author cops to “randomly” choosing data for figures in paper, colleagues say

On April 17th, Mathieu Bollen, a researcher at KU Leuven in Belgium, received a notice from PubPeer: A paper he had published in 2013 appeared to have data duplications.

The article, “Maternal Embryonic Leucine Zipper Kinase (MELK) Reduces Replication Stress in Glioblastoma Cells,” published in the Journal of Biological Chemistry, offered an explanation for why elevated levels of the MELK protein are associated with growth of a particular kind of brain tumor, glioblastoma. Several clinical trials are investigating MELK inhibitors as cancer treatments.

Bollen, the paper’s corresponding author, told Retraction Watch that one instance of image duplication, the inclusion of a gel-band from an unrelated experiment to represent a control, was “worrisome” but easily explainable:

Continue reading Author cops to “randomly” choosing data for figures in paper, colleagues say