Category: clinical study retractions

Star pediatric oncologist committed misconduct, ethical violations: reports

Stefaan Van Gool

A high-profile pediatric oncologist quietly left his former institution in 2015 after it concluded his clinical trials had been affected by significant “administrative problems.” But now the results of the university’s investigations and what followed have become public, after a paper in Belgium published a series of news reports last month.

We’re still hazy on some details of the case. The recent news reports allege that Van Gool started some clinical trials without proper ethical approvals and informed consent, and may have misled patients and their families about the benefits and potential side effects of his experimental treatment. Meanwhile, the CEO University Hospitals Leuven (UZLeuven) told us that Stefaan Van Gool, who had appointments at both the hospital and the university (KULeuven), left the hospital in 2015 as a result of administrative problems, but did not disclose the specific nature of these issues.

For the past 15 years or so, Van Gool has been developing and studying a vaccine to treat various cancers, initially at UZLeuven and, after September 2015, at a private clinic in Germany. Today, patients travel to his private clinic from all over the world and pay tens of thousands of dollars to receive the vaccine. But according to Flemish daily newspaper De Standaard, several years ago, UZLeuven began investigating his research and patient care practices. The outcome of these investigations was kept private until last month, after De Standaard published its reports.

Marc Decramer, the CEO of UZLeuven, confirmed that Van Gool left the hospital in 2015 and the university in 2016, but did not provide the specific reasons for his exit:

Continue reading Star pediatric oncologist committed misconduct, ethical violations: reports

Once-prominent researcher logs retraction following misconduct finding

A researcher who resigned from the University of Dundee in Scotland after it concluded he was guilty of misconduct has issued his first retraction.

According to an internal email to staff forwarded to us last year, the university concluded that Robert Ryan had misrepresented clinical data and images in 12 different publications. The first retraction, published by Molecular Microbiology, cites image duplications in multiple figures.

Here’s the full notice:

Continue reading Once-prominent researcher logs retraction following misconduct finding

German funder bans researcher for five years following misconduct probe

A researcher in Germany has been banned from seeking money from the largest independent research funder in the country for five years after an investigation by her former employer found her guilty of misconduct.

According to a recent announcement from the Deutsche Forschungsgemeinschaft (DFG), scientist Tina Wenz cannot apply for any DFG funding for five years, after a probe by the University of Cologne in Germany concluded she should retract six papers over misconduct.

A spokesperson for the DFG told us the agency funds more than 30,000 projects per year, and since 1998, has announced a ban due to data manipulation or misconduct only 10 times.

Continue reading German funder bans researcher for five years following misconduct probe

Two researchers guilty of misconduct, says university investigation

Suchitra Sumitran-Holgersson

A Swedish university has concluded that two professors studying tissue engineering are guilty of misconduct in two published papers, including a 2012 study in The Lancet.

The two researchers are  Suchitra Sumitran-Holgersson and Michael Olausson, both based at the University of Gothenburg. The university investigation — launched after several of Holgersson’s papers were questioned on PubPeer — has concluded that the researchers didn’t follow proper ethical procedures in the two papers.

Here’s a statement from a university spokesperson:

Continue reading Two researchers guilty of misconduct, says university investigation

Group whose findings support video game-violence link loses another paper

Last July, Joseph Hilgard, a postdoctoral fellow at the Annenberg Public Policy Center at the University of Pennsylvania, saw an article in Gifted Child Quarterly that made him do a double take. Hilgard, who is studying the effects of violent media on aggressive behavior, said the results of the 2016 paper “caused me some alarm.”

The research—led by corresponding author Brad J. Bushman, a professor of communication and psychology at The Ohio State University (OSU)—showed that gifted and non-gifted children’s verbal skills dropped substantially after watching 12 minutes of a violent cartoon. The violent program had a greater impact on the gifted children, temporarily eliminating the pre-video verbal edge they displayed over their non-gifted peers.

To Hilgard, the results suggested that violent media can actually impair learning and performance. But the effect size was huge — so big, Hilgard thought it had to be a mistake. This, plus other questions, prompted Hilgard to contact the authors and the journal. Unfortunately, once he got a look at the data — collected by a co-author in Turkey who became unreachable after the recent coup attempt — the questions didn’t go away. So the journal decided to retract the paper.

Bushman’s body of work has continually supported the idea that violent media increases aggressive behavior, including a controversial 2012 study “Boom, Headshot!” that was retracted earlier this year.

What first struck Hilgard as odd about the 2016 paper was how large the effect of the violent cartoon was: Continue reading Group whose findings support video game-violence link loses another paper

Author duplicated a figure in three papers; two get retracted

Two journals have retracted two papers by the same group within months of each other, after editors were independently tipped off that they contained duplicated figures representing different experiments.

The two papers were published by PLOS ONE and The Egyptian Journal of Biochemistry and Molecular Biology (EJBMB) in 2015 and 2014, respectively. According to the PLOS ONE paper’s corresponding author, last author Saad A. Noeman from Tanta University in Egypt used the same Figure 1 in both papers, along with another 2013 paper in EJBMB.

Corresponding author Yasser S. El-Sayed, head of the Department of Forensic Medicine and Toxicology at Damanhour University in Egypt, told us he learned of this issue after a reader brought the figure manipulation and duplication concerns to PLOS ONE’s attention.

El-Sayed said that he tried to figure out what had happened.

Continue reading Author duplicated a figure in three papers; two get retracted

“Strange. Very strange:” Retracted nutrition study reappears in new journal

In an unusual turn of events, a nutrition paper has come back to life a year after being pulled from its original publication.

After the paper was retracted from the journal Obesity, the authors revised it and republished it in another journal, Pediatric Obesity. Both journals are published by Wiley. The second version of the paper doesn’t mention the previous retraction. Indeed, the journal editor told us he didn’t know the paper had been retracted. Still, he stood by his decision to publish it.

The authors told us the paper was retracted after editors at Obesity raised concerns over the authors’ methodology. The authors revised the paper, adding some analysis and explanation of their methodological approach, and said the new version was accepted by peer reviewers before being published in Pediatric Obesity.

However, an outside expert who reviewed both papers for us said he thinks the authors didn’t change enough. According to Patrick McKnight, head of the Measurement, Research methodology, Evaluation, and Statistics group at George Mason University and a Statistical Advisory Board member of STATS.org:

Continue reading “Strange. Very strange:” Retracted nutrition study reappears in new journal

Patient misdiagnosed with rare neurological side effect in retracted case study

When two surgeons in Greece learned that a patient had developed a rare side effect following weight loss surgery, they were eager to publish the case.

After extensive testing, the patient was diagnosed with Wernicke’s encephalopathy—a neurological disorder caused by thiamine deficiency—following a sleeve gastrectomy procedure. As the authors note in the paper, they had seen only eight other cases following the procedure in the literature.

It turns out, theirs was not the ninth. After the patient unfortunately died, he was examined by a coroner, who ruled he did not, in fact, have Wernicke’s encephalopathy. So Dimitrios Manatakis and Nikolaos Georgopoulos, both based at Athens Naval and Veterans Hospital in Greece, have retracted their 2014 case study.

When the first learned of the patient, the authors wanted to alert the surgical community to the case, given the rarity of this side effect, Manatakis told us: Continue reading Patient misdiagnosed with rare neurological side effect in retracted case study

Macchiarini blames Karolinska for losing data as he retracts 2014 paper

Ask and ye shall receive: A journal has retracted a 2014 paper by Paolo Macchiarini, upon request from the Karolinska Institutet (KI).

The latest news is only one step in a long-running saga about former star surgeon Macchiarini, who was dismissed from KI last year. To read more, check out our timeline.

KI announced it was asking the journal to pull the paper late last year, after concluding that four authors — including Macchiarini — were guilty of scientific misconduct. The paper had already been flagged by the journal with an expression of concern, noting the data presented in the paper may not be “fully representative” of the experiments.

Today, the journal issued a retraction notice, saying the authors wanted to retract the paper. All of the authors who could be reached have agreed to the retraction, including Macchiarini.

Here’s more from the notice:

Continue reading Macchiarini blames Karolinska for losing data as he retracts 2014 paper

Nature paper adds non-reproducibility to its list of woes

Despite taking some serious hits, a 2006 letter in Nature isn’t going anywhere.

Years ago, a university committee determined that two figures in the letter had been falsified. The journal chose to correct the paper, rather than retract it — and then, the next year, published a correction of that correction due to “an error in the production process.” To round it out, in June of last year, Nature published a rebuttal from a separate research group, who had failed to replicate the letter’s results.

Still, the first author told us there are no plans to retract the paper, since the follow up experiments published in the corrections confirmed the paper’s conclusions.

Continue reading Nature paper adds non-reproducibility to its list of woes