Category: clinical study retractions

Big corrections usually weaken findings. But a recent NEJM one strengthened them, author says

A 2016 study in New England Journal of Medicine has received a substantial correction, which affected several aspects of the article.

Typically, an error that affects so much of a paper would undermine the results (and possibly lead to a retraction). But in this case, the revised dose calculations actually strengthened the findings, according to the first author.

The NEJM study aimed to clarify whether patients with a neuromuscular disease called myasthenia gravis benefit from a surgical procedure to remove the thymus. About half of the patients received surgery plus the steroid prednisone, while the rest only received the steroid. The researchers found patients who received the surgery fared better.

Shortly after the paper was published in August 2016, the authors discovered an error in the calculation of the average prednisone dose. According to Gil Wolfe, the first author of the paper, when the researchers corrected the error: Continue reading Big corrections usually weaken findings. But a recent NEJM one strengthened them, author says

NIH researcher doctored 11 figures in 2016 paper, says ORI

A former Research Training Awardee at the National Institutes of Health “falsified and/or fabricated data” in 11 figures in a 2016 paper, according to the U.S. Office of Research Integrity.

This is the first finding of misconduct issued this year by the ORI.

According to the finding, published in the Federal Register, Brandi M. Baughman — formerly at the National Institute of Environmental and Health Sciences (NIEHS) — tweaked data and text in a PLOS ONE paper about screening for compounds that inhibit an enzyme known as inositol phosphate kinase. According to the notice, however, some of those experiments didn’t proceed as described:

Continue reading NIH researcher doctored 11 figures in 2016 paper, says ORI

Former prof fudged dozens of images, says university

On Dec. 2, 2013, Alison Lakin, the research integrity officer at the University of Colorado Denver, received a concerning email.

The emailer was alleging several problems in a 2012 paper in the Journal of Clinical Investigation, co-authored by one of its high-profile faculty members. Lakin discussed the allegations with some administrators and agreed they had merit; Lakin sequestered an author’s laptop and other materials. Over the next few months, the university learned of additional allegations affecting other papers — and discovered even more serious problems in the JCI paper. Namely, the first author had inserted changes to 21 figures in the paper after submitting it, without alerting the other authors, journal, or reviewers.

That journal retracted the paper this month, citing numerous problems:

Continue reading Former prof fudged dozens of images, says university

Following outcry, American Psychological Association “refocuses” takedown notice program

After a deluge of protests from researchers who received notices from the American Psychological Association (APA) to remove papers from their websites, the publisher announced it will shift its focus to commercial sites.

Earlier this week, researchers took to Twitter to lament the takedown notices they had received from the APA; one posted the letter in place of his paper. The letters were part of a pilot program by the APA to remove “unauthorized online postings of APA journal articles.”

That program has now taken a bit of a turn. In a release yesterday, the APA says that:

Continue reading Following outcry, American Psychological Association “refocuses” takedown notice program

Researchers protest publisher’s orders to remove papers from their websites

Researchers are protesting orders from the American Psychological Association to remove links to papers from their websites.

Multiple researchers took to Twitter recently to lament the takedown notices they’ve received from the APA; one posted the letter in place of the link to his paper. According to the APA, the letters are part of a pilot program to “monitor and seek removal of unauthorized online postings of APA journal articles.”

The notices cite misuse of the Digital Millennium Copyright Act (DMCA), which enables internet users to protect their own content. But it can be heavily abused by people who file false copyright infringement claims to remove content they don’t like from the internet. (We have even been the target of such attempts.)

According to the letter posted by Nathaniel Daw at Princeton University, the APA says:

Continue reading Researchers protest publisher’s orders to remove papers from their websites

Ex-researcher who shot dean found guilty of attempted murder

Hengjun Chao Credit: Westchester County DA

 

A New York jury has found Hengjun Chao, a former research assistant professor at Mount Sinai, guilty of attempted second degree murder and two other charges.

Last year, Chao shot Dennis Charney, a Mount Sinai dean who had fired him in 2010 for misconduct, outside of a deli in a wealthy New York suburb. After the incident, Chao admitted to police he shot Charney. During the trial, Chao’s lawyer argued that Chao had done so to draw attention to what he believed to be misconduct at Mount Sinai.

As reported by the Chappaqua Patch, in addition to one count of attempted second degree murder, Chao was convicted of one count of criminal use of a firearm and one count of assault. He faces a maximum of 25 years in state prison.

Chao’s attorney, Stewart Orden, told Retraction Watch:

Continue reading Ex-researcher who shot dean found guilty of attempted murder

When a tractor stabs a man in the eye, who gets to write up the case report?

A journal has retracted a paper after the university notified the editors that the authors presented the gruesome details of a patient who they didn’t directly treat.

But the paper’s corresponding author disputes that claim, arguing that the first author — a radiologist, who has since passed away, provided a crucial diagnosis in this case. We’ve tried to track down the doctors who lodged a complaint about the paper, alleging they were “actually involved in the original patient treatment,” but have so far been unsuccessful.

The paper describes an unfortunate accident during which a man fell from his tractor and stabbed himself in the eye on part of the machine. Initially, doctors could not locate the eye and “believed it to have been completely destroyed,” and discharged the patient after seven days. One week later he was back, complaining of headaches — and doctors found the eye embedded deep inside the skull, intact.

According to the retraction notice, issued by the Journal of Neuro-Ophthalmology, an investigation by a university in Iran determined the doctors who initially described the case didn’t have the right to do so: Continue reading When a tractor stabs a man in the eye, who gets to write up the case report?

A retraction gets retracted — but the first author’s contract is still terminated

After issuing a retraction notice May 30 for a biomedical engineering paper, the journal has since pulled the notice, citing “a potential problem.”

After doing some digging, we’ve learned more about the “potential problem.”

Apparently, the retraction was requested by Nanyang Technological University (NTU) in Singapore. NTU has been investigating the first author for months, after it received an allegation about an unrelated manuscript. As a result, NTU terminated first author Hamidreza Namazi‘s contract as a research fellow earlier this year.

As part of the investigation, NTU began to look at Namazi’s other papers, and discovered several with potential problems — including this one, which NTU believes did not receive proper ethical approvals. So it contacted the journal to raise its concerns.

Namazi, however, told us that he and his colleague obtained approval from another organization, but didn’t make that clear in the paper — so the journal has retracted its retraction notice while it investigates Namazi’s claim.

In place of the original retraction notice, a notice now reads:

Continue reading A retraction gets retracted — but the first author’s contract is still terminated

Anesthesiology society bans co-author of researcher with record-number of retractions

The Japanese Society of Anesthesiologists has permanently banned a co-author of notorious fraudster Yoshitaka Fujii, after investigating many of his publications for alleged fraud.

According to the announcement last month (in Japanese), a committee investigated approximately 40 publications by Yuhji Saitoh of Yachiyo Medical Center and Tokyo Women’s Medical University in Japan. Saitoh resigned from the society once the investigation started; after the committee found evidence of data manipulation and fraud, the society decided it would permanently ban him as a member.

Saitoh was a frequent co-author of Yoshitaka Fujii, an anesthesia researcher with a record-breaking number of retractions (more than 180). Last year, anesthesia fraud sleuth John Carlisle and a co-author analyzed Saitoh’s papers — including many he didn’t co-author with Fujii — and concluded there was very low likelihood the sampling had been conducted randomly, among other potential concerns.

On May 9, the Japanese Society of Anesthesiologists issued the following statement, which we translated:

Continue reading Anesthesiology society bans co-author of researcher with record-number of retractions

Two in 100 clinical trials in eight major journals likely contain inaccurate data: Study

A sweeping analysis of more than 5,000 papers in eight leading medical journals has found compelling evidence of suspect data in roughly 2% of randomized controlled clinical trials in those journals.

Although the analysis, by John Carlisle, an anesthetist in the United Kingdom, could not determine whether the concerning data were tainted by misconduct or sloppiness, it suggests that editors of the journals have some investigating to do. Of the 98 studies identified by the method, only 16 have already been retracted. [See update at end.]

The types of studies analyzed — randomized controlled clinical trials — are considered the gold standard of medical evidence, and tend to be the basis for drug approvals and changes in clinical practice. Carlisle, according to an editorial by John Loadsman and Tim McCulloch accompanying the new study published today in Anesthesia, Continue reading Two in 100 clinical trials in eight major journals likely contain inaccurate data: Study