Category: clinical study retractions

Poldermans update: Magazine cites lack of informed consent, bogus patient surveys, invented data and more

Larry Husten at CardioBrief has an update on the case of Don Poldermans, a leading Dutch cardiologist who was accused of various iterations of research misconduct. Poldermans was fired last November by Erasmus Medical Center, where he had been head of perioperative cardiac care before the scandal.

According to Husten, Jeroen Bax, another prominent Dutch cardiologist with strong ties to Poldermans, has been cleared of wrongdoing by his institution, Leiden University Medical Centre: Continue reading Poldermans update: Magazine cites lack of informed consent, bogus patient surveys, invented data and more

Controversial homosexuality “reparative therapy” paper staying put despite author’s regrets

We’ve been watching with interest an unfolding flap about a controversial 2003 paper in the Archives of Sexual Behavior (ASB) by a prominent mental health researcher, Robert Spitzer, which suggested that gays could be deprogrammed by so-called “reparative therapy” to change their sexual orientation.

Spitzer, who was instrumental in the effort to extradite homosexuality from the realm of mental illnesses, apparently had developed serious doubts about the validity of his paper, which has been cited 47 times, according to Thomson Scientific’s Web of Knowledge. His regrets came to light recently in a piece by Gabriel Arana, of The American Prospect, detailing his own unfortunate experience with “ex-gay” therapy. In his article, Arana says Spitzer requested that he

  print a retraction of his 2001 study, “so I don’t have to worry about it anymore”? Continue reading Controversial homosexuality “reparative therapy” paper staying put despite author’s regrets

Group investigated by University of Louisville corrects lung cancer paper after retracting six others

A group of researchers whose work has been under investigation at the University of Louisville has issued a correction for a paper in the American Journal of Respiratory Cell and Molecular Biology (AJRCMB).

The correction follows three retractions each in the Journal of Biological Chemistry and the AJRCMB, the latter of which made it clear that lab member ShouWei Han was responsible for the manipulations and duplications that brought down the papers. Here’s the new notice, which appeared in the March 1, 2012 issue of the journal: Continue reading Group investigated by University of Louisville corrects lung cancer paper after retracting six others

193 papers could be retracted: Journal consortium issues ultimatum in Fujii case

A group of editors representing nearly two dozen medical journals has issued an ultimatum of sorts to officials at seven Japanese institutions that once employed Yoshitaka Fujii: Validate the papers of the disgraced anesthesiologist or they will be retracted.

Fujii, as we have reported, was fired by Toho University in late February, putatively for failing to obtain ethics approval for a handful of his studies. That much may be true, but the integrity of his data has been in question for more than a decade. At the time of his dismissal, journal editors expressed concern that the university would not pursue an inquiry into Fujii’s data.

Last month, the journal Anaesthesia published a statistical analysis of Fujii’s research bya UK anesthesiologist named John Carlisle which cast serious doubt on the veracity of the studies.

The joint letter forces the question. Continue reading 193 papers could be retracted: Journal consortium issues ultimatum in Fujii case

Back in the saddle: After more than 30 retractions, Naoki Mori publishing again

Naoki Mori

Perhaps it’s appropriate given the Easter season, but we have learned that Naoki Mori, the Japanese cancer researcher who received a 10-year publishing ban from the American Society of Microbiology (ASM) for imagine manipulation, has published a new paper.

Mori, who was fired and then rehired by the University of the Ryukyus over the scandal, is listed as the senior author on the paper, “Honokiol induces cell cycle arrest and apoptosis via inhibition of survival signals in adult T-cell leukemia,” which appears in the March issue of Biochimica et Biophysica Acta. The journal, an Elsevier title, is an umbrella for nine publications in the biosciences.

Two of Mori’s retracted articles appeared in the Elsevier journals Leukemia Research and Biochemical and Biophysical Research Communications. Continue reading Back in the saddle: After more than 30 retractions, Naoki Mori publishing again

JCO expresses concern over images from Spanish group that had aroused earlier concern

The Journal of Clinical Oncology has issued an expression of concern about a 2003 article by a group of researchers in Spain who appear to have had recurrent problems with images.

The paper has been cited 56 times, according to Thomson Scientific’s Web of Knowledge. Here’s the notice:

It has been brought to our attention, regarding Figure 1, Part A, that similarity exists between bands 3, 4, and 5 of the top row and bands 1, 2, and 3 of the bottom row, including the presence of artifacts, in the April 15, 2003 article by [Jose] RomanGomez et al, entitled, “Cadherin-13, a Mediator of Calcium Dependent Cell-Cell Adhesion, Is Silenced by Methylation in Chronic Myeloid Leukemia and Correlates With Pretreatment Risk Profile and Cytogenetic Response to Interferon Alfa” (J Clin Oncol 21:1472-1479, 2003).  This similarity has raised concerns about whether these rows represent independent data. We alerted the corresponding author, Dr. Roman-Gomez, of this concern, and he has repeated the experiment shown in the original Figure 1, with the results below. Although the results of the figure appear to be unchanged, we wish to inform the readers of this issue, so that they may make their own independent assessment.

Continue reading JCO expresses concern over images from Spanish group that had aroused earlier concern

Third retraction arrives for Alirio Melendez, this one in the Journal of Cellular Physiology

Alirio Melendez, the former National University of Singapore researcher who has already retracted two papers in the midst of an investigation into about 70 of his publications, has had a third retracted a third.

Here’s the notice from the Journal of Cellular Physiology: Continue reading Third retraction arrives for Alirio Melendez, this one in the Journal of Cellular Physiology

Salami slicing and heart attacks don’t mix: Duplication, lack of transparency lead to retraction

A group of French cardiology researchers have retracted a study of a potential way to rule out heart attacks, after it became clear they had used data from another study without alerting the journal.

In an unusually forthright letter accompanying the retraction of “Concomitant measurement of copeptin and high-sensitivity troponin for fast and reliable rule out of acute myocardial infarction,” originally published in Intensive Care Medicine, Bruno Riou and colleagues note: Continue reading Salami slicing and heart attacks don’t mix: Duplication, lack of transparency lead to retraction

A “retraction in part” for Anil Potti and colleagues, in Molecular Cancer Therapeutics

A partial retraction has joined the ten retractions and five corrections of Anil Potti’s papers, this one of a 2008 paper in Molecular Cancer Therapeutics. The move comes 14 months after the retraction of the Nature Medicine paper upon which much of the Molecular Cancer Therapeutics paper was based.

Here’s the notice: Continue reading A “retraction in part” for Anil Potti and colleagues, in Molecular Cancer Therapeutics

Three more retractions for resveratrol researcher Dipak Das, in free radical journals

Das, via UConn

The retraction count for Dipak Das, the resveratrol researcher whom the University of Connecticut found to have committed 145 counts of fabrication and falsification of data, has risen to eight with withdrawals by Free Radical Biology & Medicine and Free Radical Research.

The two Free Radical Biology & Medicine retractions, for “Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol” (cited 38 times, according to Thomson Scientific’s Web of Knowledge) and “Redox regulation of resveratrol-mediated switching of death signal into survival signal” (cited 32 times), are carefully detailed and read the same way: Continue reading Three more retractions for resveratrol researcher Dipak Das, in free radical journals