Category: molecular biology

Voinnet notches second retraction, two more corrections

PNASOlivier Voinnet — a plant researcher who was recently suspended for two years from the Centre national de la recherche scientifique (CNRS) after an investigation by ETH Zurich and CNRS found evidence of misconduct — has issued his second retraction and two more corrections.

PNAS posted the retraction earlier this week for a 2006 article after an inspection of the raw data revealed “errors” in study images. Authors confirmed the issues in some figures and revealed “additional mounting mistakes” in others.

Voinnet has promised to issue retractions and corrections for every study that requires them. These latest notices bring our tally up to nine corrections, two retractions and one Expression of Concern.

Continue reading Voinnet notches second retraction, two more corrections

Judge dismisses cardiac stem cell researchers’ lawsuit against Harvard

Piero Anversa
Piero Anversa

A Massachusetts judge has dismissed a lawsuit by researchers who argued that an investigation by Harvard cost them job offers.

Last year, Piero Anversa, a stem cell researcher at the Brigham & Women’s Hospital, and a colleague, Annarosa Leri, sued Harvard over an investigation into their work that they claim damaged their reputations: Continue reading Judge dismisses cardiac stem cell researchers’ lawsuit against Harvard

Penn State postdoc faked data in cancer manuscript

oriweb_logoA former postdoctoral fellow at Penn State University faked numerous data and analyses in a manuscript submitted to Molecular Cancer Research, according to the Office of Research Integrity (ORI).

In a notice released today, the ORI found Julie Massè: Continue reading Penn State postdoc faked data in cancer manuscript

What do you do after painful retractions? Q&A with Pamela Ronald and Benjamin Schwessinger

ARNOLD1
Pamela Ronald and Benjamin Schwessinger, wearing the shirts of a swim competition they entered

2013 was a rough year for biologist Pamela Ronald. After discovering the protein that appears to trigger rice’s immune system to fend off a common bacterial disease – suggesting a new way to engineer disease-resistant crops – she and her team had to retract two papers in 2013 after they were unable to replicate their findings. The culprits: a mislabeled bacterial strain and a highly variable assay. However, the care and transparency she exhibited earned her a “doing the right thing” nod from us at the time.

After many months spent understanding what went wrong and redoing the experiments correctly, today Ronald and her team release another paper in Science Advances that reveals the protein they thought they had identified in 2013.

Ronald and co-first author Benjamin Schwessinger (who recently became an independent research fellow at the Australian National University in Canberra) spoke to us about the experience of recovering from the retractions and finally getting it right. The conversation has been edited for brevity and clarity.

-What did you do differently this time so you didn’t repeat the same mistakes?

Continue reading What do you do after painful retractions? Q&A with Pamela Ronald and Benjamin Schwessinger

Duke lung researcher up to seven retractions

Enviromental Health Perspectives

More journals have pulled papers co-authored by researchers Erin Potts-Kant and Michael Foster, at Duke University, bringing the total up to seven for Potts-Kant and six for Foster.

Authors were unable to replicate the experiments after “concerns about the initial data from the animal physiology laboratory” led them to reanalyze source data, according to the note in Environmental Health Perspectives. The comparison showed “potential inconsistencies in the data,” which “significantly impact the overall conclusions of the manuscript.” Similar issues appear to have felled the pair’s other papers, including the other two recent retractions in the American Journal of Respiratory and Critical Care Medicine and the American Journal of Physiology – Lung Cellular and Molecular Physiology — but in the latter case, the discrepancies don’t affect the conclusion.

Potts-Kant was arrested on embezzlement charges in 2013. Authorities alleged that she stole almost $15,000 from Duke University.

Environmental Health Perspectives posted a retraction in July, for a 2012 paper that looked at the molecular underpinnings in airways that react to ozone.

Here’s the full notice:

Continue reading Duke lung researcher up to seven retractions

Gynecologic cancer researcher up to 13 retractions

13277Noriyuki Takai, a gynecologic cancer researcher at Oita University in Japan, has lost another five papers. With a new total of 13, that means he’s now on our leaderboard.

Three of the retractions are from the journal Tumor Biology, one is from the International Journal of Gynecological Cancer, and one from Anticancer Research.

Takai is the first author on all 5 papers.

As has been the case with Takai’s retractions, and there’s evidence that all were felled by issues with figures. In all, according to the retraction notices, “original data were processed inappropriately.” Four end with the following sentence (or some close variation thereof):

Continue reading Gynecologic cancer researcher up to 13 retractions

Gut paper retracted after university review says “figures cannot be validated by original data”

IBDA biologist at Case Western Reserve University School of Medicine in Ohio has retracted a paper from Inflammatory Bowel Diseases after a university review found the figures within it could not be “validated by original data.”

The 2010 paper, “Elevated IL-13Rα2 in intestinal epithelial cells from ulcerative colitis or colorectal cancer initiates MAPK pathway,” concerns the elevated expression and role of an inflammatory protein in colon cancer cells.

According to the notice, corresponding author and biologist Alan Levine — who recently received a $3.9 million Avant-Garde Award for HIV/AIDS Research from the National Institute on Drug Abuse — requested the retraction.

Here’s the full notice: Continue reading Gut paper retracted after university review says “figures cannot be validated by original data”

JBC retraction on neuron development marks second for two biologists

JBCTwo biologists have retracted a second paper on the development of neurons, but that’s about all we know.

The 2007 paper from the Journal of Biological Chemistry, “The Interaction of mPar3 with the Ubiquitin Ligase Smurf2 Is Required for the Establishment of Neuronal Polarity,” concerns the role of a protein, mPar3, in neuron development. It has been cited 29 times, according to Thomson Scientific’s Web of Knowledge.

We don’t know why this one was retracted, because JBC (as usual) offered no explanation in its retraction note:

Continue reading JBC retraction on neuron development marks second for two biologists

Cancer Research retraction is fifth for Robert Weinberg; fourth for his former student

13.coverAnother domino has fallen in a chain of retractions for Robert Weinberg, the man who discovered the first tumor-causing gene in humans, along with the first tumor suppressor gene: Cancer Research just retracted a paper of his on some of the molecular steps to metastasis.

The paper, “Concurrent Suppression of Integrin α5, Radixin, and RhoA Phenocopies the Effects of miR-31 on Metastasis,” has been cited 70 times, according to Thomson Scientific’s Web of Knowledge. As we have noted before, Weinberg’s papers are frequently highly cited. His bio at the Whitehead Institute bills him as “a pioneer in cancer research.”

Four of Weinberg’s retracted papers — including this latest — share a first author: Scott Valastyan, once a very promising grad student in Weinberg’s lab. 

This retraction, like Valastyan’s others, is linked to his retracted 2009 Cell paper. (That paper was cited 482 times, and there’s even a video from the Cell press office to go with it). Continue reading Cancer Research retraction is fifth for Robert Weinberg; fourth for his former student

Corrections (and one EoC) propagate for distinguished plant biologist, Olivier Voinnet

Olivier Voinnet
Olivier Voinnet

There may be some deeply rooted issues in the work of high-profile plant biologist Olivier Voinnet, biology department research director at ETH in Zurich. Corrections have continued to pile up months after his work was hit with a barrage of criticism on PubPeer. We’ve tracked a total of seven corrections over the past five months (not including the April retraction of a 2004 paper in The Plant Cell). One of the corrected papers also received an Expression of Concern this week.

Collectively, the corrected papers have accumulated more than 1200 citations.

In January, Voinnet said he planned to correct multiple papers, after receiving “an anonymous email.”

One of the recent corrections we found is for a 2003 article in The Plant Journal, “An enhanced transient expression system in plants based on suppression of gene silencing by the p19 protein of tomato bushy stunt virus,” which details using proteins from a tomato virus to help alter gene expression. The study has been cited 862 times, according to Thomson Scientific’s Web of Knowledge. Here’s the correction notice, posted June 8:

Continue reading Corrections (and one EoC) propagate for distinguished plant biologist, Olivier Voinnet