Category: molecular biology

Retraction no. 8 (and a 1/2) hits former Duke researcher Erin Potts-Kant

American Journal of Physiology - Lung Cellular and Molecular PhysiologyAnother retraction and a correction that retracts two figures — ie, a partial retraction — have been posted for Duke University lung researchers, Erin Potts-Kant and Michael Foster.

These latest notices move the count up to 8.5 retractions for Potts-Kant and 7.5 for Foster (counting the partial retraction as 1/2), along with the correction for both. In both cases and in a familiar note from previous retractions, authors found “potential discrepancies” between two sets of data (partial retraction) and study figures that weren’t “reliable” (retraction).

The retraction comes after the authors discovered problems with three of the study figures. In the corrected paper, the authors were able to validate some of their findings after repeating the experiments, but retracted two of the study figures that they were “unable to verify.”

Continue reading Retraction no. 8 (and a 1/2) hits former Duke researcher Erin Potts-Kant

5th retraction for Voinnet follows correction, EoC to PLOS Genetics paper

PLOS GeneticsAfter correcting a paper due to problematic figure panels, researchers led by high-profile biologist Olivier Voinnet have now retracted it, after “further analysis of the paper revealed flaws in the interpretation of” another figure.

PLOS Genetics published the retraction notice September 3 for the 2013 paper on the molecular details of embryonic stem cells in mice. First author Constance Ciaudo and Voinnet assume “full responsibility for the mistakes on this paper,” according to the note.

Continue reading 5th retraction for Voinnet follows correction, EoC to PLOS Genetics paper

Correction “does not change the scientific meaning” of leukemia letter

blood

The journal Blood has issued a correction in a 2009 letter about the molecular underpinnings of chronic lymphocytic leukemia.

Despite the extent of the changes to a figure, “the error does not change the scientific meaning,” according to the erratum.

The article “p73, miR106b, miR34a, and Itch in chronic lymphocytic leukemia” was written in response to a 2009 Blood paper about the role of a microRNA in CLL. But its western blots were “assembled incorrectly,” leading to duplicated panels. Another set of panels was “shifted.”

So the authors repeated the experiments, and presented them in a correction. Here’s the correction notice in full, published earlier this month, including the figures in question:

Continue reading Correction “does not change the scientific meaning” of leukemia letter

Stem cell researcher Jacob Hanna’s correction count updated to 10

Jacob Hanna
Jacob Hanna

Thanks to some eagle-eyed readers, we’ve been alerted to some corrections for high profile stem cell scientist Jacob Hanna that we had missed, bringing our count to one retraction and 13 errata on 10 papers.

The problems in the work range from duplications of images, to inadvertent deletions in figures, to failures by his co-authors to disclose funding sources or conflicts of interest. Hanna is the first or last author on 4 of the papers, and one of several on the rest.

First up, a correction to a Cell paper on which Hanna is the first author:

Continue reading Stem cell researcher Jacob Hanna’s correction count updated to 10

Researchers suspended in Japan for funding violations

Sanae Ariga
Sanae Ariga

Hokkaido University has suspended two of its professors after an investigation found “improper receipt of research funding.”

One member of the team was awarded more than 15 million yen (roughly $120,000 USD) in research grants from the Japan Society for the Promotion of Science (JSPS), according to the official statement (translated by One Hour Translation).

The researchers share a last name. Hiroyoshi Ariga, a professor of Biomedical and Pharmaceutical Science and the head of a university lab, was given 8 million yen in 2006 and 7.5 million in 2007. It appears that Sanae Ariga also received funds for a similar study, based on the translation:

Continue reading Researchers suspended in Japan for funding violations

First author refuses to sign PNAS retraction after “key findings” are not reproduced

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Two out of the three authors of a PNAS paper on mutations underlying lung diseases are pulling it after failing to reproduce key findings.

The paper, published in 2012, investigated how mutations in lung surfactant genes induce molecular changes that lead to lung pulmonary fibrosis and lung cancer might work. But follow-up work revealed problems. In the retraction note, last author Christine Kim Garcia and second author Christoper Cano, both at the University of Texas Southwestern Medical Center, write:

Current members of the C.K.G. laboratory are unable to reproduce key findings reported in the paper.

Here’s the retraction note in full:

Continue reading First author refuses to sign PNAS retraction after “key findings” are not reproduced

Investigation digs up data falsification in two papers on roundworm stress

18.coverAn investigation at the University of Florida has led to the retraction of a pair of papers on the stress responses of Caenorhabditis elegans in Molecular and Cellular Biology.

One paper has been retracted, and one “partially” retracted, as the main conclusion was “not compromised.” According to the retraction notes, the investigation found the data were “falsified” by first author Chi Leung, a former postdoc at UF.

Here’s the note in full for the partial retraction of “A Negative-Feedback Loop between the Detoxification/Antioxidant Response Factor SKN-1 and Its Repressor WDR-23 Matches Organism Needs with Environmental Conditions:”

Continue reading Investigation digs up data falsification in two papers on roundworm stress

A correction to a correction for stem cell researcher Jacob Hanna

Jacob Hanna
Jacob Hanna

A correction to a correction is the latest problem for highly cited researcher Jacob Hanna. The stem cell scientist — whose high-profile work has received scrutiny over the past year — has amended an earlier correction notice after a reader spotted an inadvertent “mistake.”

We reported on the original correction, to the 2009 Cell Stem Cell paper “Metastable Pluripotent States in NOD-Mouse-Derived ESCs,” in July. The paper has been cited 184 times, according to Thomson Scientific’s Web of Knowledge.

Apparently, a pair of images in the original correction note are of the same cell colonies, when they are supposed to be of separate cell colonies.

The new (and detailed) note explains how that happened:

Continue reading A correction to a correction for stem cell researcher Jacob Hanna

Authors withdraw immunology study, no reasons given

Journal of Biological Chemistry1Researchers have withdrawn a 2010 article in the Journal of Biological Chemistry about an immune regulator.

The paper was pulled without any explanation (in standard JBC style). Here’s the complete notice:

This article has been withdrawn by the authors.

The study’s authors were based out of Shandong University Medical School, Jinan General Hospital of Jinan Command and Duke University Medical Center.

Two of the authors have had previous papers retracted.

Continue reading Authors withdraw immunology study, no reasons given

Inquiry into duplications reveals “multiple” image problems in tumor study

STEM_17_1.c1.inddA paper on how abnormal stem cells can cause benign bone tumors has been retracted by Cell Stem Cell after an inquiry into image duplications also uncovered “multiple instances of inappropriate western blot image adjustment.”

The first two authors “declined” to sign the retraction, according to the notice.

Besides confirming initial suspicions that images had been duplicated, the editors also found “multiple instances of inappropriate western blot image adjustment, such as uneven compression of images and removal of background elements:”

Continue reading Inquiry into duplications reveals “multiple” image problems in tumor study