Category: molecular biology

STAP stem cell researcher Obokata loses another paper

Nature protocols

The first author of two high-profile Nature retractions about a technique to easily create stem cells has lost another paper in Nature Protocols.

Haruko Obokata, once “a lab director’s dream,” according to The New Yorker, also had her PhD revoked from Waseda University last fall.

After learning of concerns that two figures are “very similar” and “some of the error bars look unevenly positioned,” the rest of the authors were unable to locate the raw data, according to the note. The journal could not reach Obokata for comment before publishing the retraction.

“Reproducible subcutaneous transplantation of cell sheets into recipient mice” has been cited 21 times, according to Thomson Reuters Web of Science. It was published in June 2011, soon after Obokata earned her PhD. 

Here’s the note:

Continue reading STAP stem cell researcher Obokata loses another paper

Journals retracts three bone papers for duplication by same author

1-s2.0-S0168365907X02700-cov150hA journal is Journals are retracting three papers after a biomaterials researcher duplicated his own work, sometimes using the same figures to describe different experiments.

Two of the papers are on bone regeneration; one is about targeting tumors. In addition to issues with figures, two one of the retraction notes explain that the papers contain “widespread plagiarism of text” from other papers by the researcher, Hossein Hosseinkhani.

Hosseinkhani is currently affiliated with the National Taiwan University of Science and Technology; when he did the work in the now retracted papers, published in 2004 and 2007, he was based at Kyoto University Hospital and then National Institute for Materials Science in Japan.

The Journal of Controlled Release published all three two of the papers. Here’s the retraction note for “Bone regeneration through controlled release of bone morphogenetic protein-2 from 3-D tissue engineered nano-scaffold,” which has been cited 118 times, according to Thomson Scientific’s Web of Knowledge.

Continue reading Journals retracts three bone papers for duplication by same author

Journal retracts nanoparticles paper for duplicating figures

no spine minimum. full size. Editor: Ann Meares JEM: Diane RTP: Jill Kessler

A paper on nanoparticles that target cancer cells has been retracted for duplicating figures from three other papers.

The articles all share a first author: Manasmita Das, based at the time of the research at the Indian Institute of Technology Kharagpur and the National Institute of Pharmaceutical Education and Research (NIPER). According to her LinkedIn profile, she is currently a postdoc at the University of North Carolina.

The abstract of the 2011 Bioconjugate Chemistry paper explains just what the new nanoparticles would be useful for:

Multifunctional nanoparticles, developed in the course of the study, could selectively target and induce apoptosis to folate-receptor (FR) overexpressing cancer cells with enhanced efficacy as compared to the free drug. In addition, the dual optical and magnetic properties of the synthesized nanoparticles aided in the real-time tracking of their intracellular pathways also as apoptotic events through dual fluorescence and MR-based imaging.

But according to the retraction note, figure duplications “seriously undermine the conclusions presented in the research article.” Here’s more about the source of those duplications from the full note: Continue reading Journal retracts nanoparticles paper for duplicating figures

Researchers plagiarized chapter of doctoral thesis in mol bio paper

mol cell biochemA journal has pulled a paper about the molecular details of different types of adipose tissues after learning the researchers had plagiarized much of a Ph.D. thesis.

The researchers copied from former Ph.D. student Bettina Meissburger’s doctoral thesis in a 2013 paper in Molecular and Cellular Biochemistry. The retraction note for “Adipose stromal-vascular fraction-derived paracrine factors regulate adipogenesis” provides the name of Meissburger’s thesis: Continue reading Researchers plagiarized chapter of doctoral thesis in mol bio paper

JACS imaging paper “under editorial review”

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The Journal of the American Chemical Society has issued an expression of concern over “the presentation of results” in a 2014 paper about a new probe for use in imaging.

We haven’t heard back from the journal nor the authors of the paper, so there’s not much we can officially say about what the journal is investigating.

Here’s the text from the expression of concern:
 Continue reading JACS imaging paper “under editorial review”

Following an earlier investigation, GW biologist earns two expressions of concern

3.cover (1)The Journal of Biological Chemistry has flagged two papers by a George Washington University cancer biologist with expressions of concern, following an investigation completed by the university in 2014.

The notes contain little specific information; all we know is that there are questions about the data and conclusions in the papers.

The last author on both papers is Rakesh Kumar, who adds these EoCs to a count that includes, according to our records, three retractions and five corrections. Plus an $8 million lawsuit against his employer for emotional distress when they put him on leave from his position as department chair.

The studies — “Stimulation of inducible nitric oxide by hepatitis B virus transactivator protein HBx requires MTA1 coregulator” and “Regulation of NF-B circuitry by a component of the nucleosome remodeling and deacetylase complex controls inflammatory response homeostasis” — have been cited 22 times and 33 times respectively, according to Thomson Scientific’s Web of Knowledge.

The expression of concern is the same for both papers — and matches others that we’ve seen from JBC:

Continue reading Following an earlier investigation, GW biologist earns two expressions of concern

You’ve been dupe’d: Meet authors who like their work so much, they publish it twice

fertility and sterility

When our co-founders launched the site in 2010, they wondered whether there would be enough retractions to write about on a regular basis. Five+ years and three full-time staffers later, and we simply don’t have the time to cover everything that comes across our desk.

In 2012, we covered a group of duplication retractions in a single post, simply because duplications happen so frequently (sadly) and often don’t tell an interesting story. So in the interest of bookkeeping, we’re picking up the practice again.

Here are five unrelated retractions for your perusal: all addressing duplications, in which the same – or mostly the same – authors published the same – or mostly the same – information in two different – or sometimes the same – journals.

So, on the buffet table we offer the following entrees: Continue reading You’ve been dupe’d: Meet authors who like their work so much, they publish it twice

Wiley published a biology paper in the wrong journal

Screen Shot 2016-01-04 at 2.47.07 PMWiley Periodicals is withdrawing a biochemistry paper after mistakenly publishing it in the wrong journal.

The mistake took a few months to sort out.  Wiley initially published “Protein Kinase C Is Involved in the Induction of ATP-Binding Cassette Transporter A1 Expression by Liver X Receptor/Retinoid X Receptor Agonist in Human Macrophages” online in Journal of Cellular Physiology in May of last year. The article was posted in the correct journal — Journal of Cellular Biochemistry — in July.

At the very end of 2015, the publisher officially withdrew the version it posted in the Journal of Cellular Physiology.

Here’s the withdrawal note (which is paywalled — tsk, tsk):

Continue reading Wiley published a biology paper in the wrong journal

Three expressions of concern added to cancer researcher’s notice list

3.coverQuestions about data and conclusions in papers by a cancer researcher at the University of Maryland have led to three expressions of concern in the Journal of Biological Chemistry.

The notices follow four retractions — two for image duplications and two for unknown reasons — for Anil K. Jaiswal. The three papers under notice are all on mechanisms that regulate gene expression; PubPeer commenters have raised questions about some of the figures in the papers.

The expression of concern on all three papers reads, in full:

Continue reading Three expressions of concern added to cancer researcher’s notice list

List of retractions, corrections grows for Duke researchers

cov200hDuke researcher Michael Foster and his former co-author Erin Potts-Kant are adding to their notice count with a major correction from late last year to a paper on how certain cells in mice respond to a pneumonia infection, citing “potential discrepancies in the data.”

The correction is actually a partial retraction: The note explains that parts of three figures should be discounted.

We’ve also recently unearthed multiple corrections and two retractions from the pair that we missed from earlier in 2015.

After questions about the data in the corrected paper arose, the authors were able to replicate most of the experiments in the paper, according to the note. But since the paper was published, the senior author passed away, closing her lab, so they couldn’t repeat all of the work.

Here’s the correction notice for “Mast cell TNF receptors regulate responses to Mycoplasma pneumoniae in surfactant protein A (SP-A)−/− mice,” published in The Journal of Allergy and Clinical Immunology:

Continue reading List of retractions, corrections grows for Duke researchers