Category: cancer biology

EMBO takes back Voinnet’s award, investigates other awardee who just lost a Nature Genetics paper

Screen Shot 2016-01-28 at 11.41.20 AMEMBO has taken back an award given to beleaguered plant biologist Olivier Voinnet in 2009, and is investigating a recent grantee who had a paper retracted from Nature Genetics yesterday.

The European Molecular Biology Organization (EMBO) “promotes excellence in the life sciences” in Europe, in part by awarding prizes to promising young scientists. Voinnet and Sonia Melo earned their awards by exhibiting potential as young scientists studying genetics — of plants and cancer, respectively — but now EMBO is skeptical of the papers that formed the basis of their applications.

Melo’s Installation Grant from EMBO was announced just last month, and consists of 50,000 Euros annually for three to five years. She is currently based at the University of Porto, in Portugal.

Voinnet’s problems are well-documented on this blog — 21 corrections, seven retractions, and two investigations. Earlier this week, we reported that the Swiss National Science Foundation had cut off Voinnet’s funding, and banned him for three years. Continue reading EMBO takes back Voinnet’s award, investigates other awardee who just lost a Nature Genetics paper

Following an earlier investigation, GW biologist earns two expressions of concern

3.cover (1)The Journal of Biological Chemistry has flagged two papers by a George Washington University cancer biologist with expressions of concern, following an investigation completed by the university in 2014.

The notes contain little specific information; all we know is that there are questions about the data and conclusions in the papers.

The last author on both papers is Rakesh Kumar, who adds these EoCs to a count that includes, according to our records, three retractions and five corrections. Plus an $8 million lawsuit against his employer for emotional distress when they put him on leave from his position as department chair.

The studies — “Stimulation of inducible nitric oxide by hepatitis B virus transactivator protein HBx requires MTA1 coregulator” and “Regulation of NF-B circuitry by a component of the nucleosome remodeling and deacetylase complex controls inflammatory response homeostasis” — have been cited 22 times and 33 times respectively, according to Thomson Scientific’s Web of Knowledge.

The expression of concern is the same for both papers — and matches others that we’ve seen from JBC:

Continue reading Following an earlier investigation, GW biologist earns two expressions of concern

Ontario court quashes part of misconduct finding for prominent pair

Sylvia Asa
Sylvia Asa
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Shereen Ezzat

An Ontario court has quashed part of a misconduct finding against a prominent husband and wife team by the University Health Network in Toronto.

Last year, we reported that Sylvia Asa had stepped down from her position as Program Medical Director of the Laboratory Medicine Program at the UHN — the largest hospital diagnostic laboratory in Canada — after an investigation uncovered evidence of falsified data in two papers co-authored with her husband, Shereen Ezzat. Both of their research labs were also suspended as a result. The researchers subsequently appealed the decision.

On Friday Sunday, the Toronto Star reported that the court had set aside the finding of falsification, but upheld a finding of misconduct in the form of material non-compliance. It asked UHN to review the sanctions against both researchers, and cover their legal fees of $20,000.

Here’s the conclusion from the decision:

Continue reading Ontario court quashes part of misconduct finding for prominent pair

Lawsuit against Ole Miss for rescinded Sarkar job offer dismissed; briefs filed in PubPeer case

court caseWe recently obtained court documents showing that, in September, a judge dismissed a lawsuit filed by cancer researcher Fazlul Sarkar against the University of Mississippi after it rescinded a job offer after reviewing concerns raised about his research on PubPeer.

Sarkar’s connection to PubPeer will be familiar to many readers — he has also taken the site to court to force them to reveal the identity of the anonymous commenters who have questioned his findings. He has accused the commenters of defamation, arguing they cost him the job offer. Today, the American Civil Liberties Union filed a brief on behalf of PubPeer’s appeal of the court’s most recent ruling, that the site must disclose the identity of an anonymous commenter. At the same time, some heavy hitters in science – Bruce Alberts and Harold Varmus — and technology — Google and Twitter — filed briefs in support of the appeal.

The lawsuit against Ole Miss has brought to light the reasoning behind the school’s decision to rescind their offer to Sarkar — and the key role played by the concerns raised on PubPeer.

In a letter dated June 19, 2014 to Sarkar from Larry Walker, the director of the National Center for Natural Products Research at the University of Mississippi, Walker chides Sarkar for not revealing the extent of the ongoing questions over his research during the interview process:

Continue reading Lawsuit against Ole Miss for rescinded Sarkar job offer dismissed; briefs filed in PubPeer case

Authors retract two papers for “severe conflicts of author sequences”

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A group of authors has earned two retractions for a pair of papers on which they had “severe conflicts of author sequences,” according to the retraction note.

All of the authors were involved in a recent spate of compromised peer review that hit Springer journals back in August. Among the 64 retracted papers this summer, one included all of the authors on the two recently retracted papers, including first author Yan-Zhi Chen. Besides authorship issues, the latest two retractions also contain a “striking similarity to other publications,” according to the retraction notices.

The notes for the two papers are the same, except for the title of the paper. (They are also paywalled, tsk tsk!)

Here’s what the notes say:

Continue reading Authors retract two papers for “severe conflicts of author sequences”

Cancer Cell paper under investigation following anonymous queries on PubPeer

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A Cancer Cell paper that caused a flurry of activity on the website PubPeer is under investigation, after the last author announced on the site that he’d requested a correction from the journal.

The 2012 paper sparked a lively dialogue last month on the post-publication discussion site, as commenters questioned Western blot images in which some bands appeared to be duplicates. The last author responded, noting he had alerted the journal to a “mishap,” and a correction would be forthcoming. However, some commenters remained unsatisfied, and questioned why the correction was taking so long to appear, as well as the explanation for what went wrong.

A spokesman from Cancer Cell confirmed to us the paper is under investigation:

Continue reading Cancer Cell paper under investigation following anonymous queries on PubPeer

Suspicions of data manipulation lead to correction of testicular cancer paper

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The corresponding author of a paper on testicular cancer is telling readers to discount a figure after she learned it may have been manipulated.

Although that one figure in the 2005 paper in the British Journal of Cancer may be problematic, the authors found data to support the other figures, and its conclusions.

This isn’t the first time first author Kerry Manton has faced questions over her data — in 2012, one of her papers was retracted following an investigation by her institution, the Queensland University of Technology. And in 2014, QUT repaid a $275,000 grant after finding Manton

failed to fulfill (her) responsibilities in relation to the responsible dissemination of research findings and that this, coupled with a failure to correct the errors, constituted research misconduct.

Here’s the corrigendum for “Hypermethylation of the 5′ CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis:”

Continue reading Suspicions of data manipulation lead to correction of testicular cancer paper

Prostate cancer paper retracted after investigation can’t review original image

1.coverAn article about how a COX-2 inhibitor (celecoxib) inhibits growth of prostate cancer in rats is being retracted after the authors were unable to provide an investigation committee at New York University with the backup they were asking for.

When the paper was published in 2003, first author Bhagavathi Narayanan worked at the Institute for Cancer Prevention in New York (also known as the American Health Foundation). But when the institute went broke the next year — thanks partly to lavish salaries and offices, as the New York Post reported —  the authors claim they could no longer obtain back up for an image in the paper, once it was questioned years later by NYU, where Narayanan is now based.

Here’s the retraction note, published in Clinical Cancer Research:

Continue reading Prostate cancer paper retracted after investigation can’t review original image

Cancer study pulled when published without supervisor’s consent

turkish jThe Turkish Journal of Medical Sciences has retracted a paper after concerns surfaced from a researcher who claims to have supervised the research but was not listed as a co-author.

The first author completed the research — which explored the use of epigenetic alterations as potential early signs of cancer — as part of her master’s degree, under the supervision of Muy-Teck Teh at the Barts & The London School of Medicine & Dentistry. When Teh contacted the journal to say he had not consented to the publication, Ayesha Umair claimed she had paid for the research herself.

Here’s the retraction note for “Quantitative study of epigenetic signature in head and neck squamous cell carcinoma,” which tells us more about the dispute: Continue reading Cancer study pulled when published without supervisor’s consent

“Compromised” peer review hits three papers from Nature Publishing Group

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Nature Publishing Group is retracting three papers today, after an investigation found evidence the peer-review process had been compromised.

The publisher issued a statement saying they had notified corresponding authors and institutions associated with the three papers, which were all published last year in the journals Cancer Gene Therapy and Spinal Cord. 

Here’s the note that’s going on each of the papers, (they’re the same, except for the publication date):

Continue reading “Compromised” peer review hits three papers from Nature Publishing Group