Authors reused images in three papers, concludes journal probe

JBCBiologists are retracting three papers after the journal concluded they contain reused images, designed to represent different experiments. The authors stand by the conclusions, some of which they say have been “extensively validated.”

The Journal of Biological Chemistry used image analysis software to evaluate the images, first published at least a decade ago. Unfortunately, the raw data behind the problematic images were not available. The authors have also corrected a fourth paper in another journal, and wrote on PubPeer that they are working with journals to address concerns in three more.

The papers share two authors: Mireia Duñach at the Autonomous University of Barcelona, and Antonio García de Herreros at the Institut Hospital del Mar d’Investigacions Mèdiques. A representative of the Institut Hospital del Mar d’Investigacions Mèdiques told us it is looking into Garcia de Herreros’s work.

We’ll start with “β-Catenin N- and C-terminal tails modulate the coordinated binding of adherens junction proteins to β-catenin,” which has been cited 45 times since it was published in 2002, according to Thomson Reuters Web of Science. The retraction notice says:

Continue reading Authors reused images in three papers, concludes journal probe

JAMA takes all calls for retraction seriously — even from PETA

JAMAA leading medical journal is taking a second look at a recent high-profile paper about elephants’ lower risk of cancer, after receiving a call for retraction from a somewhat unusual corner: the animal rights group PETA.

This isn’t the first time the activist group has called for a retraction — last year, it nudged a journal to pull a paper that had been flagged for fraud by the U.S. Office of Research Integrity. Their latest target: A 2015 paper in JAMA, which PETA claims contains inaccurate information.

What’s more, the organization argues, Ringling Bros and Barnum & Bailey Circus — which partly funded the research — is using the findings as “justification for the continued use of abusive training techniques with elephants.” Yesterday, PETA sent a letter to the journal asking it to either retract the paper or issue an expression of concern, claiming: Continue reading JAMA takes all calls for retraction seriously — even from PETA

Fraudster’s colleague faked data, too

ori-logoA week after announcing that a researcher formerly at the University of Chicago had faked the results of more than 70 experiments, the U.S. Office of Research Integrity announced yesterday that one of his colleagues also falsified data.

According to the ORI, Karen D’Souza  Continue reading Fraudster’s colleague faked data, too

JACS corrects, removes author from previously flagged paper

JACSA paper at the center of a high-profile case of alleged misconduct in Hong Kong has earned a correction notice.

The correction replaces an expression of concern on the Journal of the American Chemical Society (JACS) paper, which followed allegations of data manipulation. It provides some un-cropped images, and removes a co-author from the paper. However, it does not appear to address previous allegations of misconduct, nor a recent ruling from an investigation at Hong Kong University (HKU), which found that some of the data were “invalid.”

Here is the correction notice for “Molecular Imaging of Peroxynitrite with HKGreen-4 in Live Cells and Tissues:”

Continue reading JACS corrects, removes author from previously flagged paper

Economists go wild over overlooked citations in preprint on prenatal stress

The_American_Economic_Review_(cover)Citation omissions in an economics preprint have set off a wave of recrimination and speculation on a widely read economics discussion board.

Commenters accuse the authors of purposely omitting citations that would have undermined the paper’s claims to novelty and contributions to the field, leveling acrimony and personal attacks. Economists Petra Persson at Stanford and Maya Rossin-Slater at the University of California, Santa Barbara told us they hadn’t been familiar with the omitted papers at the time they first posted their preprint, but their work remains distinct from these previous studies. Nevertheless, the two quickly updated the preprint of their paper – accepted by the top-tier economics journal American Economic Review – to include additional citations. An editor at the journal said it’s not unusual for authors to request such changes before publication, and dismissed the accusations made on the discussion board, calling the site “not a legitimate source of information.”

The study, “Family Ruptures, Stress, and the Mental Health of the Next Generation,” used data from Swedish national databases to compare mental health outcomes of people born to women who lost a relative while pregnant and women who lost a relative in the first year after giving birth. Continue reading Economists go wild over overlooked citations in preprint on prenatal stress

How should journals update papers when new findings come out?

NEJM Logo

When authors get new data that revise a previous report, what should they do?

In the case of a 2015 lung cancer drug study in the New England Journal of Medicine (NEJM), the journal published a letter to the editor with the updated findings.

Shortly after the paper was published, a pharmaceutical company released new data showing the drug wasn’t quite as effective as it had seemed. Once the authors included the new data in their analysis, they adjusted their original response rate of 59%  — hailed as one of a few “encouraging results” in an NEJM editorial at the time of publication — to 45%, as they write in the letter. One of the authors told us they published the 2015 paper using less “mature” data because the drug’s benefits appeared so promising, raising questions about when to publish “exciting but still evolving data.”

It’s not a correction, as the original paper has not been changed; it doesn’t even contain a flag that it’s been updated. But among the online letters about the paper is one from the authors, “Update to Rociletinib Data with the RECIST Confirmed Response Rate,” which provides the new data and backstory:

Continue reading How should journals update papers when new findings come out?

Duplicated data gets corrected — not retracted — by psych journal

Psychological Science

A psychology journal is correcting a paper for reusing data. The editor told us the paper is a “piecemeal publication,” not a duplicate, and is distinct enough from the previous article that it is not “grounds for retraction.”

The authors tracked the health and mood of 65 patients over nine weeks. In one paper, they concluded that measures of physical well being and psychosocial well being positively predict one another; in the other (the now corrected paper), they concluded that health and mood (along with positive emotions) influence each other in a self-sustaining dynamic.

As a press release for the now-corrected paper put it: Continue reading Duplicated data gets corrected — not retracted — by psych journal

Software glitch — not intentional manipulation — sunk immunology paper, says author

kuo photo
A black box appears over the control lane on the left

New evidence suggests a retracted paper was felled not by intentional manipulation — as it first appeared — but by a software glitch.

In 2014, we reported that Biochemical Journal had retracted a paper on suspicion it contained “shoddy Photoshopping”  — someone appeared to have blacked out a control lane in one figure. Now there’s evidence that it wasn’t done on purpose: An investigation at Duke into eight papers, including the Biochemical Journal paper, did not find evidence of misconduct; lead author Paul Kuo, currently chair of surgery at Loyola Medicine, told us that a glitch in the software caused the black box. Nevertheless, the journal does not plan to un-retract the paper. Continue reading Software glitch — not intentional manipulation — sunk immunology paper, says author

In major shift, medical journal to publish protocols along with clinical trials

AIMA major medical journal has updated its instructions to authors, now requiring that they publish protocols of clinical trials, along with any changes made along the way.

We learned of this change via the COMPare project, which has been tracking trial protocol changes in major medical journals — and been critical of the Annals of Internal Medicine‘s response to those changes. However, Darren Taichman, the executive deputy editor of the journal, told us the journal’s decision to publish trial protocols was a long time coming: Continue reading In major shift, medical journal to publish protocols along with clinical trials

After painful retraction, authors republish replicated findings five years later

chembiochemIt was one of the most difficult posts we’ve ever written: A researcher’s eagerness to publish a paper before asking all co-authors for their permission forced him to retract the article, wasting a postdoc’s time and destroying a professional relationship in the process.

This 2011 post wasn’t difficult to write because the facts were complex; they weren’t particularly (although the science involved was intricate). Rather, the man responsible for the incident, Graham Ellis-Davies, was so clearly and sincerely distressed by the mistake he’d made, it was impossible not to feel sorry for the him.

Well, we’re delighted to report that the tale has a happy ending. Ellis-Davies and his former postdoc have recently republished their once-retracted work with a new set of co-authors — and in the same journal that previous retracted it. What’s more, they have turned what initially was a proof-of-concept study into a much more robust article with exciting implications for the field.  Continue reading After painful retraction, authors republish replicated findings five years later