Category: by journal

More questions arise over gene-editing tool

13238A new letter signed by 20 researchers is casting additional doubts on the validity of a potentially invaluable lab tool — and alleges the lab that produced the initial results turned them away when they tried to replicate its findings in mammalian cells.

In a letter published this week in Protein & Cell, the researchers add their voices to the critics of the gene-editing technique, first described earlier this year in Nature Biotechnology.

The researchers outline their attempts to apply the technique — known as NgAgo — to a variety of cell types, which fell short:

Continue reading More questions arise over gene-editing tool

Authors retract paper lacking approval to study asthma in athletes

british-journal-of-sports-medicineThe authors of a 2014 study about asthma in Norwegian athletes have retracted it after realizing they hadn’t obtained proper approval from an ethical committee.

The study’s first and corresponding author of the study in the British Journal of Sports Medicine — Julie Stang from the Norwegian School of Sports Sciences in Oslo — told us the authors had struggled to obtain ethical approval for the research, but believed the issue had been resolved.

However, earlier this year, a member of an ethical committee wrote an article in the Norwegian press about his concerns regarding the study, which tested the effects of three drugs on top athletes’ breathing. In it, he said the Regional Committees for medical and health professional research ethics (REC) had not approved the study, as members were concerned the presumably healthy athletes were being exposed to drugs used to treat asthma, which could enhance their performance. 

Stang has denied that the study had anything to do with boosting athletic performance.

Stein Evensen, the committee member who wrote the article, declined to comment beyond the published text. So we’ve gotten the kronikk article translated from Norwegian using One Hour Translation. It reads: Continue reading Authors retract paper lacking approval to study asthma in athletes

Authors pull two papers about faulty glucose meters after industry prompts

4.coverTwo papers evaluating glucose meters — used by diabetics to monitor blood sugar levels — suggested that a couple of the devices don’t work as well as they should. Perhaps unsurprisingly, the companies that sell those meters objected to how the studies were conducted. By all accounts, the companies appear to be justified in their complaints.

In both cases, researchers used blood drawn from veins to test the meters. But manufacturers of the WaveSense JAZZ and GlucoRx glucose meters said their devices are designed to work with fresh blood from a finger-prick. Both papers have now been retracted.

The retraction notice for “Technical and clinical accuracy of five blood glucose meters: clinical impact assessment using error grid analysis and insulin sliding scales,” published in 2015 in the Journal of Clinical Pathology, hints at the issue:

Continue reading Authors pull two papers about faulty glucose meters after industry prompts

Nature Cell Bio paper may be headed for retraction

ncbA Nature Cell Biology paper published only a few months ago by prominent researchers in Taiwan has sparked a heated discussion on PubPeer, which now includes a comment allegedly from an author saying they have requested its retraction.

Although a representative of the journal wouldn’t confirm to us that the authors had requested a retraction, the comment on PubPeer says the paper contains several figures that were “inappropriately manipulated” by the first author.

Here’s the full comment on PubPeer, tagged as coming from one of the authors of the paper:

Continue reading Nature Cell Bio paper may be headed for retraction

Should journals reject papers solely on ethical grounds?

biological-conservation

Recently, an ecology journal received a submission that made them pause. In order to conduct their research, the authors had to kill thousands of fish. The study had been approved by conservation authorities, but it still wasn’t sitting well with the journal.

So it rejected the paper, on ethical grounds.

Biological Conservation explained its decision in a recent paper, noting the killing of thousands of vertebrates (marine and freshwater fish) in a protected area was “unnecessary and inappropriate,” and adds the journal will continue questioning and rejecting papers that “do not meet reasonable standards of practice.”

This is not a universal practice, however — years ago, The New England Journal of Medicine (NEJM) published the results of a research project that resulted in 90 people becoming infected with HIV. Again, that study had obtained the necessary ethical approvals — but should the journal act as the final judge?

According to the editors of Biological Conservation, yes. In “Field work ethics in biological research,” they write: Continue reading Should journals reject papers solely on ethical grounds?

Two Harvard-led groups pull well-cited cancer papers for duplication

the-journal-of-clinical-investigationTwo sets of authors based largely at Harvard Medical School have each retracted a paper for duplication in the same journal.

Both papers — which are more than a decade old — were pulled in The Journal of Clinical Investigation on November 1 by their respective corresponding authors.

One paper’s last author told us it was difficult to identify how the duplications occurred since the study took place so long ago, but added that multiple experiments had corroborated the results.

Here’s the first retraction notice for “Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism:” Continue reading Two Harvard-led groups pull well-cited cancer papers for duplication

Official notice published for chem paper slated for retraction in 2011

process-safetyAfter five years, Elsevier has finally issued a notice of retraction for a paper it announced it was pulling for fraud in 2011.

All of the papers were produced by a research group in Brazil; all were retracted after the publisher conducted an investigation, concluding that the NMR results had been manipulated. At the time, the last author on the latest retraction, Claudio Airoldi, defended the work. Since then, however, Airoldi has logged two more retractions, bringing his total to 13.

Here’s the full text of the retraction notice, from Process Safety and Environmental Protection: Continue reading Official notice published for chem paper slated for retraction in 2011

Researcher denies faking reviews for 5 newly retracted papers

engineering-failure-analysisJournals have retracted five papers by a materials researcher based in Poland after concluding the peer-review process had been faked. 

According to the retraction notices — which all appear in Elsevier journals and contain the same text — the papers were accepted due to “positive advice of at least one faked reviewer report,” which were submitted from fictitious email accounts for reviewers suggested by the author.

All five studies were solely authored by Mariusz Książek, who is based at the Wrocław University of Science and Technology in Poland, and has denied any wrongdoing.

A spokesperson from the Wrocław University of Science and Technology confirmed that the university “has taken legal actions.” 

Książek told Retraction Watch why he doesn’t agree with the decision to retract his papers: Continue reading Researcher denies faking reviews for 5 newly retracted papers

Analysis casts doubt on bone researcher’s body of work

19-coverA new analysis of more than 30 clinical trials co-authored by a bone researcher based in Japan is casting doubt on the legitimacy of the findings.

Yoshihiro Sato, based at Mitate Hospital, has already retracted 12 papers, for reasons ranging from data problems, to including co-authors without their consent, to self-plagiarism. Most of these retracted papers are included in the analysis in the journal Neurology, which concluded that Sato’s 33 randomized clinical trials exhibited patterns that suggest systematic problems with the results.

Other researchers have used similar approaches to analyze a researcher’s body of work — notably, when John Carlisle applied statistical tools to uncover problems in the research of notorious fraudster Yoshitaka Fujii, and Uri Simonsohn, who sniffed out problems with the work of social psychologist  Dirk Smeesters.

Author Mark Bolland of the University of Auckland told us he was surprised by his findings: Continue reading Analysis casts doubt on bone researcher’s body of work

Genetics study flagged for reliability issues by Frontiers journal

frontiers-in-geneticsA genetics journal has issued an expression of concern (EOC) for a study after an investigation by its chief editors.

According to the notice in Frontiers in Genetics, the authors of the paper — based at Hokkaido University in Sapporo, Japan — are conducting further experiments to resolve the issues raised by the journal’s investigation.

In February, the same paper received a corrigendum due to errors in the assembly of one of the figures.

Here’s the EOC, issued earlier this week: Continue reading Genetics study flagged for reliability issues by Frontiers journal