An international team of researchers from the NIH, Harvard, the University of Michigan, and two Chinese universities — Fourth Military Medical University and China Medical University — has retracted their 2012 paper in Nature after they — and a number of other groups — were unable to reproduce the key results.
The original abstract for “The NAD-dependent deacetylase SIRT2 is required for programmed necrosis” said that the findings
implicate SIRT2 as an important regulator of programmed necrosis and indicate that inhibitors of this deacetylase may constitute a novel approach to protect against necrotic injuries, including ischaemic stroke and myocardial infarction.
But here’s the notice, by corresponding author Toren Finkel and colleagues: Continue reading Nature paper retracted following multiple failures to reproduce results