Category: bmj

Following criticism, BMJ “clarifies” dietary guidelines investigation

downloadThe BMJ has issued two “clarifications” to an investigation it published last week that questioned whether the new U.S. dietary guidelines were evidence-based.

The article criticized several aspects of the new dietary guidelines, such as “deleting meat from the list of foods recommended as part of its healthy diets” — without, according to author Nina Teicholz, reviewing the scientific literature on meat. However, according to the clarification, that sentence should have specified “lean” meats.

After The BMJ‘s article appeared, an analysis on The Verge questioned whether Teicholz was guided by her own opinions. She’s the author of a book The Big Fat Surprise: Why Butter, Meat and Cheese Belong in a Healthy Diet. The Dietary Guidelines Advisory Committee also posted a lengthy “rapid response” — The BMJ‘s refined version of a comment section — to Teicholz’s article, saying it “strongly disagrees with many of the statements represented as facts.”

This afternoon, Rebecca Coombes, head of investigations and features at The BMJ, posted a response: Continue reading Following criticism, BMJ “clarifies” dietary guidelines investigation

Can you spot the signs of retraction? Just count the errors, says a new study

downloadClinical studies that eventually get retracted are originally published with significantly more errors than non-retracted trials from the same journal, according to a new study in BMJ.

The authors actually called the errors “discrepancies” — for example, mathematical mistakes such as incorrect percentages of patients in a subgroup, contradictory results, or statistical errors.

The study doesn’t predict which papers will eventually be retracted, since such discrepancies occur frequently (including one in the paper itself), but the authors suggest a preponderance could serve as an “early and accessible signal of unreliability.”

According to the authors, all based at Imperial College London, you see a lot more of these in papers that are eventually retracted: Continue reading Can you spot the signs of retraction? Just count the errors, says a new study

Re-analysis of controversial Paxil study shows drug “ineffective and unsafe” for teens

downloadThe antidepressant Paxil isn’t safe or effective for teens after all, says a re-analysis of a 2001 study published today in The BMJ.

The original 2001 paper in Journal of the American Academy of Child and Adolescent Psychiatry — study 329, as it’s known — helped greenlight use of the drug (generically known as paroxetine) in young people. But it’s faced accusations of ghostwriting, undisclosed conflicts of interest, and issues with data analysis since publication.

According to a BMJ feature, also published today: Continue reading Re-analysis of controversial Paxil study shows drug “ineffective and unsafe” for teens

Nutrition researcher Chandra loses libel case against CBC

CBCThe self-proclaimed “father of nutritional immunology,” Ranjit Kumar Chandra, has lost a libel lawsuit against the Canadian Broadcasting Company (CBC).

The suit was in response to a 2006 three-part documentary from the CBC, which examined allegations of fraud against the former Memorial University researcher.

After the 58-day trial, the Ontario Superior Court of Justice “ruled in favour of CBC, on the grounds that the words in the broadcast were true,” according to CBC producer Lynn Burgess: Continue reading Nutrition researcher Chandra loses libel case against CBC

Half of anesthesiology fraudster’s papers continue to be cited years after retractions

ethicsIn yet more evidence that retracted studies continue to accrue citations, a new paper has shown that nearly half of anesthesiologist Scott Reuben’s papers have been cited five years after being retracted, and only one-fourth of citations correctly note the retraction.

According to the new paper, in Science and Engineering Ethics: Continue reading Half of anesthesiology fraudster’s papers continue to be cited years after retractions

“Irregularities” lead to retraction of paper on delirium

spcarecoverA paper on delirium in older adults has been withdrawn by a geriatric journal, after the clinical hospital notified the journal of problems in the data.

Here’s the notice for “Issues Associated with Delirium Severity Among Older Patients,” which first appeared in BMJ Supportive & Palliative Care: Continue reading “Irregularities” lead to retraction of paper on delirium

Panel says BMJ was right to not retract two disputed statin papers

bmjA panel reviewing The BMJ‘s handling of two controversial statin papers said the journal didn’t err when it corrected, rather than retracted, the articles.

The articles — a research paper and a commentary — suggested that use of statins in people at low risk for cardiovascular disease could be doing far more harm than good. Both articles inaccurately cited a study that provided data important to their conclusions — an error pointed out vigorously by a British researcher, Rory Collins, who demanded that the journal pull the pieces.

In a letter to Godlee this spring, Collins wrote: Continue reading Panel says BMJ was right to not retract two disputed statin papers

Second paper falls for ex-Leiden researcher accused of fraud

atrdLast November we wrote about the retraction of a 2010 paper in PNAS by Annemie Schuerwegh and colleagues. Schuerwegh had been fired from Leiden University in The Netherlands for fraud, which said there would be a second retraction coming.

It has.

The article, “Anti-citrullinated protein antibodies in rheumatoid arthritis: a functional role for mast cells and basophils?” had appeared in the Annals of the Rheumatic Diseases. According to the retraction notice: Continue reading Second paper falls for ex-Leiden researcher accused of fraud

BMJ authors take back inaccurate statin safety statements

bmjcover514Last October, the BMJ published a paper by a group of researchers from the United States and Canada questioning the use of statins in patients considered at low risk of cardiovascular disease.

The article has been cited eight times since then, according to Thomson Scientific’s Web of Knowledge. It mentioned data from another study that reported a high rate of side effects in patients who used the drugs, between 18% and 20% — suggesting that those who received little or no benefit from the therapy could be more more likely to suffer harm than good.

But that citation turns out to have been flawed — prompting the journal to take the unusual step of removing those “statements” from the article and another it published about the issue that has been cited six times. And in an editorial, BMJ editor Fiona Godlee said she has asked a panel of experts to review the original paper to determine if it ought to be retracted completely: Continue reading BMJ authors take back inaccurate statin safety statements

Data “irregularities” prompt retraction of palliative care papers

bmjspcA group of researchers in Singapore has lost two 2013 articles in BMJ Supportive & Palliative Care for problems with their data.

One of the articles was titled “Patients with Dysphagia: Encounters in Taking Medication;” the other, “Issues Associated with Delirium Severity Among Older Patients.” In both cases, the first and second authors were Rajaram S and Chua HC, of Khoo Teck Puat Hospital.

According to the retraction notices:

Continue reading Data “irregularities” prompt retraction of palliative care papers