Study by deceased award-winning cancer researcher retracted because some patients were “invented”

cancerA 2002 paper has been retracted by Cancer after some of the authors notified the journal that they hadn’t agreed to submit it — and an investigation found that a number of the patients described had been made up.

Here’s the notice for “Radioimmunotherapy of small-volume disease of metastatic colorectal cancer: results of a phase II trial with the iodine-131–labeled humanized anti–carcinoembryonic antigen antibody hMN-14:” Continue reading Study by deceased award-winning cancer researcher retracted because some patients were “invented”

Stats error has chilling effect on global warming paper

global change biologyIt turns out a 2014 paper that found a surprising pattern of plant migration in response to global warming was not so surprising after all — it’s been retracted by the authors due to a mistake in the statistical analysis.

Most studies on migrating populations have found that species around the globe move north to escape the rising temperatures. But the authors of the 2014 paper in Global Change Biology found the opposite — according to their analysis, many plant species in Western North America had been migrating south, toward warmer climates.

The lead author Melanie Harsch told Science in 2014 that the team had been suspicious of the analysis, and so ran it twice: Continue reading Stats error has chilling effect on global warming paper

Poll: What to do when peer review feels inadequate?

Imagine via Raul Pacheco-Vega
Image via Raul Pacheco-Vega

How should scientists think about papers that have undergone what appears to be a cursory peer review? Perhaps the papers were reviewed in a day — or less — or simply green-lighted by an editor, without an outside look. That’s a question Dorothy Bishop, an Oxford University autism researcher, asked herself when she noticed some troubling trends in four autism journals.

Recently, Bishop sparked a firestorm when she wrote several blog posts arguing that these four autism journals had a serious problem. For instance, she found that Johnny Matson, then-editor of Research in Developmental Disabilities and Research in Autism Spectrum Disorders, had an unusually high rate of citing his own research – 55% of his citations are to his own papers, according to Bishop. Matson also published a lot in his own journals – 10% of the papers published in Research in Autism Spectrum Disorders since Matson took over in 2007 have been his. Matson’s prodigious self-citation in Research in Autism Spectrum Disorders was initially pointed out by autism researcher Michelle Dawson, as noted in Bishop’s original post.

Short peer reviews of a day or less were also common. Matson no longer edits the journals, both published by Elsevier.

Bishop noted similar findings at Developmental Neurorehabilitation and Journal of Developmental and Physical Disabilities, where the editors (and Matson) frequently published in each others’ journals, and they often had short peer reviews: The median time for Matson’s papers in Developmental Neurorehabilitation between 2010 and 2014 was a day, and many were accepted the day they were submitted, says Bishop.

Although this behavior may seem suspect, it wasn’t necessarily against the journals’ editorial policies. This is the peer review policy at RIDD:

Continue reading Poll: What to do when peer review feels inadequate?

Wayne State neuroscientist fudged images in five papers

Teresita L. Briones
Teresita L. Briones

Teresita Briones, a former nursing professor at Wayne State University in Detroit who studied neuroscience, manipulated images in five papers, according to the Office of Research Integrity.

Briones, who focused on neuroplasticity: Continue reading Wayne State neuroscientist fudged images in five papers

Former Columbia postdoc faked Alzheimer’s research in Cell and Nature

cover_natureRyousuke Fujita, a former Columbia University postdoc who admitted to having faked the findings of a 2011 Cell paper in a retraction notice last year, also faked the results of a 2013 Nature paper, according to a new report from the Office of Research Integrity (ORI).

Fujita’s work, in conjunction with Asa Abeliovich, was widely hailed as a significant step forward, a way to turn skin cells into brain cells. But the story began falling apart when the Cell retraction said that he “acknowledged inappropriately manipulating image panels and data points, as well as misrepresenting the number of repeats performed.”

The ORI’s findings in the case also involve a 2013 Nature paper, “Integrative genomics identifies APOE ε4 effectors in Alzheimer’s disease,” and a paper never published. Fujita, according to the ORI: Continue reading Former Columbia postdoc faked Alzheimer’s research in Cell and Nature

Second paper for Duke lung researchers expires in a retraction

pnas 3 5 13Scientists at Duke and the National Institutes of Health have retracted a PNAS paper on asthma treatment after realizing the data from two sources didn’t match, and “most primary data” from several experiments were missing.

The mix up seems to have come from the pulmonary function laboratory that tested how well asthmatic patients’ lungs were functioning on an experimental anti-inflammatory therapy. As the authors say in the retraction note: Continue reading Second paper for Duke lung researchers expires in a retraction

Other shoe drops for MIT cancer researcher Robert Weinberg as Cell retraction appears

cell cloningRobert Weinberg, a prominent cancer scientist whose papers often notch hundreds or thousands of citations, has lost a fourth paper, this time a 2009 publication in Cell.

Journal Genes and Development pulled two of Weinberg’s papers in March, stating that they had retracted the 2009 study because data from several experiments was used in figures that seemed to represent only one. The Genes and Development papers were sunk because the “same analytical methodology was used.”

At the time, the Cell retraction was unavailable, though a spokesperson informed us it was forthcoming. The paper has been cited 482 times, according to Thomson Scientific’s Web of Knowledge.

Now that the notice has landed, here’s why the paper is being retracted: Continue reading Other shoe drops for MIT cancer researcher Robert Weinberg as Cell retraction appears

Retraction and republication for Lancet Resp Med tracheostomy paper

lancetrmA paper whose expression of concern we covered in November 2014 has been retracted and republished “because of the extent of the changes necessary,” according to the Lancet Respiratory Medicine.

This isn’t the first time we’ve seen retraction/republications at the Lancetaccompanied by thorough breakdowns of the problem.

This study was a meta-analysis of research on how the timing of tracheostomies — placing a breathing tube directly into the windpipe — affects patients’ mortality rate. The original paper found that critically ill patients who received a tracheostomy earlier fared better than those for whom the procedure was delayed for weeks after intubation, the recommended practice.

However, when the authors calculated how many patients died, they assumed that any patient who wasn’t discharged from the intensive care unit (ICU) had died there, instead of looking for other explanations. This made their estimates unreliable.

The publisher convened a panel, which ultimately decided retraction and republication was the most appropriate course of action.

The original expression of concern contained a quote from the authors about the “data discrepancy” that would later sink the paper: Continue reading Retraction and republication for Lancet Resp Med tracheostomy paper

Cancer Cell issues big correction over “incorrectly cropped” figures, other issues

cancer cell A 2014 Cancer Cell paper became the subject of an erratum in January 2015, shortly after PubPeer members began criticizing the data. However, many issues brought up by commenters weren’t addressed in the correction notice, including a figure that might be two experiments spliced together to look like one.

The paper, led by Guido Franzoso at Imperial College London, claims that a new cancer drug called DTP3 kills myeloma cells “without causing any toxic side effects,” according to a press release from the school. Guido Franzoso is the founder of Kesios Therapeutics, a drug company which is set to begin clinical trials on DTP3.

The correction indicates that Western blots were cropped badly, which omitted several panels discussed in the text, while an “extra time point” was included accidentally. An antibody was also omitted from the description of the procedure.

PubPeer commenters have noticed additional issues, such as a criticism of figure 3D, which were not included or changed in this correction.

Here’s the correction for “Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors”: Continue reading Cancer Cell issues big correction over “incorrectly cropped” figures, other issues

“Serious and obvious mistakes” kill paper on heart attacks in rats

j card pharmA group of researchers in China and the United States have retracted a 2014 paper in the Journal of Cardiovascular Pharmacology after discovering the data were fatally flawed.

The article examined whether the anti-arrhythmia drug zacopride affected cardiac remodeling after heart attack, and came from Bo-We Wu, of Shanxi Medical University, in Taiyuan, and colleagues, including one author from Savannah, Georgia.

Here’s more from the notice for “Activation of IK1 channel by zacopride attenuates left ventricular remodeling in rats with myocardial infarction”:

Continue reading “Serious and obvious mistakes” kill paper on heart attacks in rats