Category: by author

Macchiarini defends ethics of 2011 Lancet paper

Paolo Macchiarini
Paolo Macchiarini

Embattled trachea surgeon Paolo Macchiarini, who has spent more than a year fighting misconduct allegations, is defending the ethical oversight behind one of his seminal papers published in The Lancet.

The 2011 paper “Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept study” described a first-of-its-kind procedure: A 36-year-old man with recurrent tracheal cancer received an artificial airway seeded with his own stem cells. The news launched Macchiarini into the stratosphere. And then the questions came. Continue reading Macchiarini defends ethics of 2011 Lancet paper

Court dismisses lawsuit by XMRV-chronic fatigue syndrome researcher

mikovitsA California court has dismissed virologist Judy Mikovits’s lawsuit against fourteen people and two Nevada corporations, in part because she failed to submit necessary documents on time.

Mikovits is the author on a now-retracted Science paper suggesting a link between a virus known as XMRV and chronic fatigue syndrome, which has no known cause. She alleged that she was fired from the Whittemore-Peterson Institute for blowing the whistle on her former colleague’s activities, and that the defendants then colluded to imprison and defame her.

The court dismissed her case last Wednesday. According to the court minutes,

Continue reading Court dismisses lawsuit by XMRV-chronic fatigue syndrome researcher

Seralini paper released by predatory publisher is plagiarized by predatory journal

ijtra-logoA 2012 paper co-authored by Gilles Seralini, who has published controversial research showing the dangers of genetically modified foods, has been plagiarized by another researcher.

The 2016 paper, published in the International Journal of Technical Research and Applications, has not been retracted, but the text comparison is fairly obvious.

It’s a case of intra-predatory crime: the International Journal of Technical Research and Applications is on the list of predatory journals compiled by Jeffrey Beall, and the Seralini paper appeared in the Journal of Environmental Protection, which is published by Scientific Research Publishing, which Beall considers to be a predatory publisher.

Here’s the abstract from Seralini’s 2012 paper, “Glyphosate Exposure in a Farmer’s Family:” Continue reading Seralini paper released by predatory publisher is plagiarized by predatory journal

8th retraction appears for researcher who faked patient records

S00219150An 8th paper has been retracted for Anna Ahimastos, a heart researcher who faked patient records.

It’s the last in a chain of retractions that were the result of an investigation by her former workplace, Baker IDI Heart & Diabetes Institute in Australia. As with the others, she did not agree to the retraction.

The investigation found fabricated patients records in some papers; in other papers, such as the newly retracted 2010 study in Atherosclerosis, the original data source could not be verified.  The latest retraction — “A role for plasma transforming growth factor-β and matrix metalloproteinases in aortic aneurysm surveillance in Marfan syndrome?” — followed up on a previous clinical trial, examining how a blood pressure drug might help patients with a life-threatening genetic disorder.

That previous trial — which also included 17 patients with Marfan syndrome treated with either placebo or perindopril — has been retracted from JAMA; the New England Journal of Medicine has also retracted a related letter.

The latest retraction note conveys similar information to the other perindopril/Marfan syndrome retractions: Continue reading 8th retraction appears for researcher who faked patient records

Karolinska vice-chancellor resigns following criticism of Macchiarini investigation

Anders Hamsten
Anders Hamsten

Anders Hamsten announced he would be resigning as vice-chancellor from Karolinska Institutet (KI) in the early hours of Saturday, February 13.

In a press release we received at 12:16 a.m. local time in Stockholm, Hamsten issued the following statement:

Following the criticism on the so called Macchiarini affair at KI I conclude it will be hard for me to serve as Vice-Chancellor with the strength and credibility this university needs. I will therefore leave office.

Good thing we published a primer on the whole story a few hours ago. To recap: Continue reading Karolinska vice-chancellor resigns following criticism of Macchiarini investigation

Reading about embattled trachea surgeon Paolo Macchiarini? Here’s what you need to know

Paolo Macchiarini
Paolo Macchiarini

The media has been abuzz in the last few weeks with developments in the ongoing story about “super surgeon” Paolo Macchiarini. We’ve been covering the allegations against him for years (and invited him to publish a guest post on our site). Below, we present a timeline of recent events, to keep you abreast of what we know so far.

Macchiarini was famous long before accusations of misconduct arose, once-heralded for creating tracheas from cadavers and patients’ own stem cells. However, the glow of his success was diminished somewhat after some Karolinska Institutet (KI) surgeons filed a complaint in 2014 — alleging, for instance, Macchiarini had downplayed the risks of the procedure and not obtained proper consent. In response, KI issued an external review by Bengt Gerdin of Uppsala University.

Here’s what’s happened since: Continue reading Reading about embattled trachea surgeon Paolo Macchiarini? Here’s what you need to know

Nobel Prize official resigns in wake of Macchiarini case

Urban Lendhal
Urban Lendhal

The secretary general of the Nobel Assembly, the body responsible for choosing the Nobel Prizes, has resigned from his post because “he may be involved” in the Karolinska Institutet investigation of trachea surgeon Paolo Macchiarini.

Urban Lendahl, professor of genetics at the Karolinska, has also resigned as secretary general of the Nobel Committee in Physiology or Medicine. Here’s a statement released yesterday by the Nobel Assembly: Continue reading Nobel Prize official resigns in wake of Macchiarini case

Investigation prompts 5th retraction for cancer researcher for “unresolvable concerns”

3.coverAn investigation at the University of New South Wales in Australia has led to a fifth retraction for a cancer researcher long accused of misconduct, due to “unresolvable concerns” with some images.

As we reported in December, UNSW cleared Levon Khachigian of misconduct, concluding that his previous issues stemmed from “genuine error or honest oversight.” Now, Circulation Research is retracting one of his papers after an investigation commissioned by UNSW was unable to find electronic records for two similar images from a 2009 paper, nor records of the images in original lab books.

Again, the retraction note affirms that this is not a sign of misconduct:

UNSW has not attributed any instance of research misconduct or responsibility for the unavailability of the original data to Professor Khachigian or to any of the authors of the publication.

Here’s the retraction note in full for “Angiotensin II-Inducible Smooth Muscle Cell Apoptosis Involves the Angiotensin II Type 2 Receptor, GATA-6 Activation, and FasL-Fas Engagement:” Continue reading Investigation prompts 5th retraction for cancer researcher for “unresolvable concerns”

Karolinska orders new investigation of trachea surgeon Macchiarini

Paolo Macchiarini
Paolo Macchiarini

The Karolinska Institutet University Board announced today it was issuing a new external investigation of trachea surgeon Paolo Macchiarini, looking into questions about his recruitment and the handling of previous allegations of misconduct.

According to a press release:

The University Board deems such an inquiry to be an important part of restoring the confidence of the public, the scientific community, staff and students in the university.

The board hopes to appoint the investigative team, which will not consider “matters of a medical-scientific nature,” next week. The goal is to conclude the investigation by the summer.

There were many signs this was coming:  Continue reading Karolinska orders new investigation of trachea surgeon Macchiarini

Karolinska won’t extend star surgeon Macchiarini’s contract

dr-paolo-macchiarini
Paolo Macchiarini

Karolinska Institutet announced today it would not extend the contract of star surgeon Paolo Macchiarini. He has been instructed to “phase out” his research from now until November 30.

According to a press release issued today: Continue reading Karolinska won’t extend star surgeon Macchiarini’s contract