Archive for the ‘cell biology’ Category
Two cancer researchers who hold a patent on a particular pathway that might be a target for new drugs — and one of whom leads a company that is studying those potential drugs — have retracted two related papers in the Journal of Biological Chemistry (JBC).
The notices for “Kinase suppressor of Ras signals through Thr269 of c-Raf-1“ and “The kinase activity of kinase suppressor of Ras1 (KSR1) is independent of bound MEK,” which share H. Rosie Xing and Memorial Sloan-Kettering’s Richard Kolesnick as authors, say the same thing: Read the rest of this entry »
mBio, whose editor, Arturo Casadevall, has contributed greatly to our knowledge about why articles are retracted, has an interesting retraction of its own.
The journal — a publication of the American Society for Microbiology and the American Academy of Microbiology — is pulling a 2011 paper by a trio of researchers from the University of Alabama, Birmingham, Li Tan, Mei Li and Charles L. Turnbough Jr. The article was titled “An Unusual Mechanism of Isopeptide Bond Formation Attaches the Collagenlike Glycoprotein BclA to the Exosporium of Bacillus anthracis.” The paper, which has been cited twice, according to Thomson Scientific’s Web Knowledge, purported to show that:
A team of researchers led by Daniel St. Johnston, director of the Gurdon Institute at Cambridge and a prominent developmental biologist in the UK, has lost a pair of articles after finding that their data were unreliable. But rather than “correct” the record with subsequent papers, they’ve withdrawn the problematic work.
To our mind, this is a poster case of doing the right thing by science. We think the notices — as provided by the authors and reported by the journals — pretty much say it all, so we’ll let them speak for themselves, followed by some details St. Johnston shared with us.
The first article, “LKB1 and AMPK maintain epithelial cell polarity under energetic stress,” appeared in 2007 in the Journal of Cell Biology and has been cited 108 times, according to Thomson Scientific’s Web of Knowledge.
According to the retraction notice:
Here’s a retraction from Stem Cells and Development that we’re just now getting around to covering. The paper, “Non-viral reprogramming of skeletal myoblasts with valproic acid for pluripotency,” appeared in June 2012 in a preliminary online form and was written by a group at the University of Cincinnati. As the retraction notice states: Read the rest of this entry »
The paper, “Derivation and Genetic Modification of Embryonic Stem Cells from Disease-Model Inbred Rat Strains,” came from the lab of Aron Geurts, of the Medical College of Wisconsin.
Here’s a warning to would-be plagiarizers: Don’t submit to the journal Molecules unless you have no problem being called out by name when you’re busted.
Consider: The journal is retracting a paper it published earlier this year after learning that the article contained verbatim text — and lots of it — from previously published papers.
The article, “Cytotoxicity and Anti-Inflammatory Activity of ethylsulfanyltriazoloquinazolin,” was written by a group that included Amira M. Gamal-Eldeen, of the National Research Center in Cairo, Egypt. Why single out Dr. Gamal-Eldeen, you ask? Read for yourself: Read the rest of this entry »
MIT’s Robert Weinberg, a leading cancer researcher who retracted a Cancer Cell paper earlier this year for “inappropriate presentation” of figures, has corrected a different paper in the same journal.
Here’s the correction for “Species- and Cell Type-Specific Requirements for Cellular Transformation:”
We were apprised recently of errors made in the assembly of Figures 2B, 3A, 4A, 4B, and 5G, resulting in the incorporation of incorrect representative images in these figures. These errors occurred during the electronic assembly and have no bearing on the conclusions of the study. The corrected figures are shown below. The authors apologize for any possible confusion this might have caused.
Here’s the original Figure 2 and caption, followed by the new version (read all the way to the end of the post for more details on how this came to light): Read the rest of this entry »
We’ll say it again: We like being able to point out when researchers stand up and do the right thing, even at personal cost.
In December 2011, Pamela C. Ronald, of the University of California, Davis, and colleagues published a paper in PLOS ONE,”Small Protein-Mediated Quorum Sensing in a Gram-Negative Bacterium.” Such quorum sensing research is a “hot topic” right now, so not surprisingly the paper caught the attention of other scientists, and the media, including the Western Farm Press. The study has been cited eight times, according to Thomson Scientific’s Web of Knowledge.
One of those scientists who took notice was Ronald’s UC Davis colleague Jonathan Eisen, who posted about the paper on his blog. That was on January 9, 2012. But if you go to that post today, you’ll see that Eisen struck through most of it, and added this comment: Read the rest of this entry »