Category: clinical study retractions

Fraud’s long tail: Measles outbreak shows why it’s important to look downstream of retractions

Child with measles, via Wikipedia/CDC
Child with measles, via Wikipedia/CDC

As Retraction Watch readers know, public health officials are concerned about a U.S. measles outbreak. As The New York Times notes:

The United States has already had more cases of measles in the first month of 2015 than the number that is typically diagnosed in a full year. This follows a year in which the number of cases was several times more than the average since 2000, when the disease was declared eliminated in the United States.

As Retraction Watch readers also know, the discredited autism-vaccines link, fears of which lead some parents to skip their kids’ vaccations, rears its ugly head periodically. Much of the related anti-vaccine movement can be tied to a 1998 study in the Lancet by Andrew Wakefield and colleagues that was eventually retracted in 2010: Continue reading Fraud’s long tail: Measles outbreak shows why it’s important to look downstream of retractions

After 25 years, AIDS fraud comes back swinging

Screen Shot 2015-01-30 at 5.20.32 PMHenk Buck, a Dutch chemist who once claimed he could cure AIDS, is back, publishing a long explanation of why he was right all along in a journal by what Jeffrey Beall calls a possible predatory publisher.

Buck spent a few months in 1990 as a hero. In April of that year, he and his team published a paper in Science that claimed they could prevent HIV from infecting human cells. Buck went on a press blitz, appearing on TV and the radio claiming that there would be a treatment for AIDS “in a few years,” according to an 1991 comment published in Science. 

Like many things that sound too good to be true, the AIDS cure was a fraud. Continue reading After 25 years, AIDS fraud comes back swinging

Unspecified questions earn central line study an expression of concern

ajicThe American Journal of Infection Control has issued an expression of concern for a paper looking at ways to reduce infections associated with central venous catheters, or central lines.

The catheters are placed directly into a large vein and end close to the heart, allowing long-term access for medication or fluid administration. According to the CDC, infections associated with central lines cause thousands of deaths and cost billions of dollars every year.

Here’s the abstract for “Comparison of central line-associated bloodstream infection rates when changing to a zero fluid displacement intravenous needleless connector in acute care settings“: Continue reading Unspecified questions earn central line study an expression of concern

Lancet retracts and republishes cardiology paper with admirable notice

logo_lancetOne of the papers from a massive heart disease study in China, published in the Lancet, has been retracted and republished after the authors noticed a statistical error.

The article, by authors from Peking Union Medical College in China, Yale University, and elsewhere, presented the results of the China PEACE-Retrospective Acute Myocardial Infarction Study, part of a national initiative to study and improve care for cardiac problems. After being posted online on June 24, 2014, the authors noticed that they’d incorrectly weighed one of the cities in their calculations, which threw off a number of national estimates.

After the corrections were made, the paper was peer-reviewed again, and reviewers stated that despite the mistakes, the original conclusions were sound.

Today is a banner day on Retraction Watch: This is our second excellent example of transparency in 24 hours, and therefore the second entry in our “doing the right thing” category. An editorial lays out exactly what happened, including a timeline, allowing scientists to feel confident they’re basing the next research step on solid and accurate data. (We also appreciate the hat tip to the Committee on Publication Ethics retraction guidelines, which we often send out to editors of bad notices as a gentle reminder.)

Here’s the notice for “ST-segment elevation myocardial infarction in China from 2001 to 2011 (the China PEACE-Retrospective Acute Myocardial Infarction Study): a retrospective analysis of hospital data”: Continue reading Lancet retracts and republishes cardiology paper with admirable notice

Authors issue a model retraction for mistaken bacterial identity

jcmA group in the Netherlands has retracted a case study on the diarrheal pathogen Campylobacter jejuni, commonly found in animal feces, after repeated tests showed the bacteria was actually C. fetus, which also causes spontaneous abortion in cows and sheep.

The 46-year-old man who had previously had an aortic valve replacement came to the doctors with endocarditis, an inflammation of the heart. Initial tests showed that it was due to a C. jejuni infection, which often lives in chickens, wombats, kangaroos, and sheep.

Only a few cases of endocarditis caused by C. jejuni had ever been reported. Unfortunately, a thorough followup made it clear that a different pathogen was at play. Let’s consider this retraction a model for all others in its clarity and thoroughness.

Take it away, notice for “Aortic Homograft Endocarditis Caused by Campylobacter jejuni“: Continue reading Authors issue a model retraction for mistaken bacterial identity

Fraud retraction appears for deceased Maryland dental researcher

osomoporeA former dental researcher at the University of Maryland, Baltimore, has lost a 2009 paper in the journal Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology for fabricating his data on an NIH-funded study.

The researcher, Mark A. Scheper, is not identified in the retraction notice as the person implicated in the university investigation. However, one of his co-authors confirmed his involvement. Scheper died in January 2014 at age 45 of natural causes, according to the Maryland State Medical Examiner.

The article was titled “The oncogenic effects of constitutive Stat3 signaling in salivary gland cancer cells are mediated by survivin and modulated by the NSAID sulindac.” It appeared online in March 2009, and has been cited six times, according to Thomson Scientific’s Web of Knowledge.

According to the abstract: Continue reading Fraud retraction appears for deceased Maryland dental researcher

Bad image prompts correction of Harvard-Brigham stem cell paper by Anversa

circresA group of Harvard stem cell researchers who already have one retraction and an expression of concern now have a correction. This one’s in Circulation Research, and it involves an image that previously had been flagged as suspicious in our comments.

The group is led by Piero Anversa, who as we reported last year is one of two researchers suing Harvard because the institution’s investigation into their work

has cost them millions in a forfeited sale of their company, and job offers.

Continue reading Bad image prompts correction of Harvard-Brigham stem cell paper by Anversa

Former Pitt cancer researcher admits to faking findings

Dong Xiao
Dong Xiao

A former researcher at the University of Pittsburgh inflated the number of mice used in his experiments, and faked data in a number of images in a paper reporting the results, according to the Office of Research Integrity (ORI).

Dong Xiao admitting to having

intentionally fabricated data contained in a paper entitled ‘Guggulsterone inhibits prostate cancer growth via inactivation of Akt regulated by ATP citrate signaling,’ specifically Figure 6G,

the ORI reports. The paper was published in  in July 2014 in Oncotarget. Here’s Figure 6: Continue reading Former Pitt cancer researcher admits to faking findings

Retracted paper on herbicide-ovarian cancer connection republished

ehpA retracted 2008 paper originally flagged by Clare Francis has been republished in Environmental Health Perspectives with updated figures and new data.

According to the editor’s note appended to the newly published paper, there was no evidence of intentional misconduct on the part of the authors. The new paper went through peer review as an entirely new submission, and comes to the same conclusion as the original:  Continue reading Retracted paper on herbicide-ovarian cancer connection republished

Franken-paper from U.S. federal contractor heads to the grave

Image via Insomnia Cured Here.
Image via Insomnia Cured Here.

Hindawi journal PPAR Research has pulled a cancer immunology paper after discovering it contained almost no new information.

Instead, it was a Frankenstein-style stitch job, containing sentences ripped from 33 different papers. 18 of those ended up in the citations; for 15 more, the authors didn’t even do them that courtesy. You can see a meticulously color-coded call out here.

Here’s the notice for “A Role for PPARy in the Regulation of Cytokines in Immune Cells and Cancer”: Continue reading Franken-paper from U.S. federal contractor heads to the grave