Category: clinical study retractions

Two more retractions appear for prominent MIT cancer researcher Robert Weinberg

genes and developmentTwo identical retraction notices have popped up for MIT professor Robert Weinberg, a highly-cited cancer researcher who had a retraction and a correction in 2013, both in Cancer Cell. 

These two new retractions, in Genes and Development, stem directly from another paper by Weinberg and colleagues in Cell that will apparently be retracted, as the “same analytical methodology was used,” according to the notices [see bottom of the post for an update].

Weinberg is highly regarded, and at least 20 of his papers have been cited over a thousand times.

First author Scott Valastyan was a promising postdoc at the time of the paper’s publication. He was a 2011 Runyon Fellow at Harvard, a three-year, $156,000 award for outstanding cancer postdocs. He doesn’t seem to have published anything since 2012, though he is listed as a joint inventor with Weinberg on patents filed in 2009 and 2014.

Here are the notices for “Concomitant suppression of three target genes can explain the impact of a microRNA on metastasis” (cited 73 times, according to Thomson Scientific’s Web of Knowledge) and “Activation of miR-31 function in already-established metastases elicits metastatic regression” (cited 54 times), both paywalled: Continue reading Two more retractions appear for prominent MIT cancer researcher Robert Weinberg

Sticky situation: Paper using honey for healing pulled over data issues

honey
Image via Hillary Stein

A paper on dressing wounds with honey has been retracted after the journal realized that an outlier patient was throwing off the data analysis.

Honey has been used for millennia as an antimicrobial wound dressing. Doctors can even buy sterile preparations of the sweetener. But the evidence that honey is better than other wound dressings is still inconclusive.

According to the retracted paper, published in International Wound Journal in 2008, Manuka honey has an acidic pH which helps reduce the alkaline environment of chronic woulds. Indeed, the authors found that Manuka honey dressings lowered wound pH and reduced wound size.

Sadly, the paper was pulled in 2014, after someone realized one patient had a particularly large wound that was throwing off statistics. The injury was 61 cm^2 at the beginning of the study, while the others ranged from .9 to 22 cm^2. After removing that patient from the analysis, the results no longer held up.

Continue reading Sticky situation: Paper using honey for healing pulled over data issues

Psychology retractions have quadrupled since 1989: study

stapel
Diederik Stapel

Marc Hauser. Dirk Smeesters. Diederik Stapel.

Psychology has been home to some of the most infamous cases of fraud in recent years, and while it’s just a few bad apples who are spoiling the bunch, the field itself has seen an overall increase in retractions, according to a new paper by Jürgen Margraf appearing in Psychologische Rundschau and titled “Zur Lage der Psychologie.”

That increase, Margraf found, is not entirely due to its most well-known fraudsters. Here’s the relevant figure:

Continue reading Psychology retractions have quadrupled since 1989: study

Diabetes researcher won’t give up court fight to quash expressions of concern

Mario Saad, via unicamp.br
Mario Saad, via unicamp.br

Apparently, you can’t keep Mario Saad down.

The researcher, who had 12 figures in a paper corrected this week, was dealt a setback last week when a judge denied his motion to remove expressions of concern on four of his papers in the journal Diabetes, saying that would have amounted to prior restraint — essentially, censorship (a no-no, thanks to the First Amendment).

Saad and his attorneys, however, were undeterred. They filed a motion for reconsideration just four days later, along with a brief, arguing: Continue reading Diabetes researcher won’t give up court fight to quash expressions of concern

Second exercise study retracted in four-paper pileup

nursing and health scienceWe recently wrote about three papers on heart health and exercise that came under fire for reporting the same trial in three different ways. Actually, make that four ways (so far).

The Wiley journal Nursing and Health Sciences has retracted a fourth paper from the group, saying the “main study” was “previously published.” The notice mentions all three previous papers, one of which has already been retracted and another withdrawn from publication.

Here’s the notice for “Can the transtheoretical model motivate patients with coronary heart disease to exercise?”: Continue reading Second exercise study retracted in four-paper pileup

Heart journal issues expression of concern after fraud report

circulationThe American Heart Association’s journal Circulation has issued an expression of concern for a paper about the molecular underpinnings of arrhythmias that was co-authored by a biomedical engineer who committed fraud on a massive scale.

According to an investigation by the Office of Research Integrity (ORI), former Vanderbilt engineer Igor Dzhura faked nearly 70 images and drastically over-estimated the number of experiments he conducted. He was banned from receiving federal funding for three years.

The fraud has resulted in six retracted papers, Dzhura has agreed to retract six papers, which have been cited more than 500 times. [Ed. note: at this time, only one paper has actually been retracted]

Continue reading Heart journal issues expression of concern after fraud report

Judge denies motion by researcher to quash Diabetes expressions of concern

Mario Saad, via unicamp.br
Mario Saad, via unicamp.br

American Diabetes Association 1, Mario Saad 0.

As reported by the National Law Journal, a federal judge in Boston has denied Saad’s requests to stop the ADA’s flagship journal, Diabetes, from publishing expressions of concern about four of Saad’s papers, and to prevent the journal from retracting the studies.

Saad filed suit against the ADA on February 5. Judge Timothy Hillman wrote in his order yesterday that approving the researcher’s motion would have violated the right to free speech: Continue reading Judge denies motion by researcher to quash Diabetes expressions of concern

Frontiers lets HIV denial article stand, reclassifies it as “opinion”

frontiers phFollowing an investigation sparked by criticism for its decision to publish a paper questioning the link between HIV and AIDS, a Frontiers journal has decided to not retract the article but rebrand it as an “opinion.”

In September, 2014, Patricia Goodson, a professor of health education at Texas A&M University, published an article called “Questioning the HIV-AIDS hypothesis: 30 years of dissent.”

The paper was quickly called into question, and the journal, Frontiers in Public Health, issued a statement of concern and promised to look into the problem. Now, they’ve announced their solution: call the paper an “opinion” and publish an argument against it.

Continue reading Frontiers lets HIV denial article stand, reclassifies it as “opinion”

A rare event: Toronto Star retracts fear-mongering vaccine story

TorontoStarOriginalGardasilHeadlineFifteen days after publishing a widely-criticized article linking anecdotal health problems to the HPV vaccine Gardasil, the Toronto Star has issued a retraction.

The Page 1 story, “A wonder drug’s dark side,” was full of health horror stories from women who became sick “sometime after” the vaccine, as the retraction notes – twitching limbs, feeding tubes, even death. Each of these stories came from the Vaccine Adverse Event Reporting System, a public database of anecdotes maintained by the U.S. government to help monitor rare side effects that might emerge when the vaccine is given to millions of people.

In mining this database of self-reported illness, the Star failed to give equal weight to the large body of scientific evidence that says Gardasil has very low rates of adverse effects and a huge public health benefit. The publisher’s note both acknowledges the criticism and explains where the story went wrong:

Continue reading A rare event: Toronto Star retracts fear-mongering vaccine story

Misconduct forces retraction of health behavior paper

j behav medA pair of psychology researchers at West Virginia University have lost their 2013 article in the Journal of Behavioral Medicine after one of the authors was found to have cooked the data.

The paper, “Preference for immediate reinforcement over delayed reinforcement: relation between delay discounting and health behavior,” was written by Shane Melanko and Kevin Larkin. It examined whether people who place less importance on the future were also less likely to adopt healthy behaviors, which come with delayed benefits. Melanko, then a doctoral candidate under Larkin, was evidently at one time a psychology student of some promise.

That promise might go unfulfilled. According to the retraction notice: Continue reading Misconduct forces retraction of health behavior paper