Category: clinical study retractions

Is post-hoc statistical analysis the new fraud detection tool? A new review looks at fraudster Reuben’s work

In the beginning, there was Scott Reuben.

Well, not quite. Reuben, a Massachusetts anesthesiologist who fabricated data and briefly topped our list of most-retracted authors, didn’t invent research fraud, although he did spend six months in federal prison for his crimes. But his case was in no small measure responsible for the birth of this blog, and, well, the rest of human history that followed.

Although Reuben’s retractions are behind him now — his count ends at 22 — and other scientists, including two anesthesiologists, Joachim Boldt and Yoshitaka Fujii, have or likely soon will dramatically eclipsed his mark, a new paper has revisited his publications with an eye toward seeing if they could identify statistical evidence of data manipulation. It’s the same  kind of effort that Ed Yong highlighted as noteworthy about the Dirk Smeesters case, which we covered yesterday and which involved an anonymous statistically inclined whistleblower.

Before we get to whether there was evidence of such manipulation Continue reading Is post-hoc statistical analysis the new fraud detection tool? A new review looks at fraudster Reuben’s work

Following investigation, Erasmus social psychology professor retracts two studies, resigns

Dirk Smeesters

The social psychology community, already rocked last year by the Diederik Stapel scandal, now has another set of allegations to dissect. Dirk Smeesters, a professor of consumer behavior and society at the Rotterdam School of Management, part of Erasmus University, has resigned amid serious questions about his work.

According to an Erasmus press release, a scientific integrity committee found that the results in two of Smeesters’ papers were statistically highly unlikely. Smeesters could not produce the raw data behind the findings, and told the committee that he cherry-picked the data to produce a statistically significant result. Those two papers are being retracted, and the university accepted Smeesters’ resignation on June 21.

The release also takes pains to say that the university has no reason to doubt the work of his co-authors. You can read the complete report in Dutch, with Smeesters’ co-authors’ names blacked out, in an NRC Handelsblad story.

Erasmus tells Retraction Watch that these are the two papers being retracted: Continue reading Following investigation, Erasmus social psychology professor retracts two studies, resigns

Three more retractions for weight loss surgeon Edward Shang for making up data

Edward Shang, the weight loss surgeon who lost his job at the University of Leipzig in May after it was revealed that he had made up most, if not all, of the patients in his research studies at the University of Mannheim, has retracted three more papers.

Here’s the notice, which is a bit, um, lean, given what we know about the case: Continue reading Three more retractions for weight loss surgeon Edward Shang for making up data

JPET corrects Janssen antidepressant paper after neuroscience blogger notes errors

Are drug company R&D departments reading blogs?

In a recent paper, “Translational evaluation of JNJ-18038683, a 5-HT7 receptor antagonist, on REM sleep and in major depressive disorder,” researchers with New Jersey-based Janssen Pharmaceuticals Inc. tested whether a potential drug code-named JNJ-18038683 that binds to a receptor linked to depression could actually help patients.

Turns out, the drug was a flop, but Continue reading JPET corrects Janssen antidepressant paper after neuroscience blogger notes errors

Serial plagiarizers banned from dermatology journal forever

Last August, we brought you the news that the Indian Journal of Dermatology had banned a group of Tunisian researchers from publishing in the journal for five years, because they had plagiarized in a 2009 study.

Well, the journal’s editors found another case in which the authors have plagiarized, and now they’re banned from the journal for good. Here’s the notice, which describes both cases: Continue reading Serial plagiarizers banned from dermatology journal forever

PLoS ONE expresses concern over flu vaccine paper

via Wikimedia

PLoS ONE has issued an expression of concern over a  2010 paper by Chinese scientists about how the immune system responds to the vaccine against the swine flu.

The article, “Protection Induced on Day 10 Following Administration of the 2009 A/H1N1 Pandemic Influenza Vaccine,” claimed to study 58 subjects given the inoculation (more on that below) and that Continue reading PLoS ONE expresses concern over flu vaccine paper

Tell-tale hearts: Cardiology journals retract redundant articles

The European Journal of Cardiothoracic Surgery has retracted a 2007 article by Chinese researchers after the senior author decided he liked the data so nice he’d publish them twice. And he appears to have done so without the knowledge of the corresponding author.

Here’s the notice for the paper, titled “Open-heart surgery in patients with liver cirrhosis”: Continue reading Tell-tale hearts: Cardiology journals retract redundant articles

Circulation retracts four papers by author who misled on IRB approval

Circulation has retracted four articles by a pediatric cardiologist in Japan who failed to obtain ethics approval for the studies in question but evidently lied about it to the journal.

The researcher, Hideaki Senzaki, of Saitama Medical University, is a highly-published investigator who trained for a time with at Johns Hopkins.

According to the Circulation notice: Continue reading Circulation retracts four papers by author who misled on IRB approval

Lead author of major breast cancer study announced at ASCO co-authored two corrected papers with Anil Potti

One of the biggest stories so far out of the American Society of Clinical Oncology (ASCO) meeting that just ended in Chicago was that of T-DM1, which, according to Ivan’s Reuters colleagues, “extended the length of time breast cancer patients lived without their disease getting worse.” (The news was even the subject of an embargo break.)

The widely-hailed study of Roche’s drug was led by Duke’s Kimberly Blackwell, who told The New York Times: Continue reading Lead author of major breast cancer study announced at ASCO co-authored two corrected papers with Anil Potti

Retraction count for resveratrol researcher Dipak Das rises to 12

Das, via UConn

Dipak Das, the UConn researcher whom the university earlier ths year found to have fabricated or falsified data more than 100 times, has four more retractions to his name.

The notices appear in the June 1, 2012 issue of the American Journal of Physiology: Heart and Circulatory Physiology, and suggest that Das was not all that cooperative: Continue reading Retraction count for resveratrol researcher Dipak Das rises to 12