Category: basic life sciences retractions

NIH cancer paper retracted for faked data

JCIFollowing an investigation into research misconduct, the Journal of Clinical Investigation has retracted a cancer genetics paper from a laboratory at the National Institutes of Health due to “data falsification and fabrication” of four figures and a table in the paper.

The paper, “FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer,” describes an overexpressed gene in mouse prostate cancers that appears to suppress immune system cells.

The journal retracted the paper following an investigation into author Stephanie K. Watkins, then a postdoctoral fellow at the National Cancer Institute. According to a NIH press release released about the study in March 2011, the work “has led to the submission of a patent application by the NIH on behalf of Hurwitz and Watkins to target FOXO3 as a way to boost immune responses in cancer and to silence excessive immune responses in autoimmune diseases.” We found an NIH record of the patent application, but no record of an approved patent at the United States Patent and Trademark Office under either Hurwitz or Watkins’ names.

The paper has been cited 62 times, according to Thomson Scientific’s Web of Knowledge. Here’s the full notice: Continue reading NIH cancer paper retracted for faked data

Drunk rats paper wasted by “significant statistical errors”, among other issues

MolBiolRep_ak5Authors from Xinxiang Medical University in Weihui, China, are retracting a 2014 paper in Molecular Biology Reports because… well, because lots of things.

The researchers exposed nine rats to acute levels of alcohol then compared them to unexposed mice rats, noting differences in gene expression and molecular pathways.

But no one is toasting these findings anymore. Here are the details behind the retraction, courtesy of the notice:

Continue reading Drunk rats paper wasted by “significant statistical errors”, among other issues

Authors retract leptin paper due to “fabricated data”

CellPress_ak2The authors of a study on the effects of the hormone leptin on the liver have retracted it from Cell Metabolism, almost four months after the Office of Research Integrity (ORI) determined it contained faked data, courtesy of its first author.

However, the authors say that the paper’s conclusions remain valid, and are supported by new experiments and additional research by outside groups.

Here’s more from the retraction notice: Continue reading Authors retract leptin paper due to “fabricated data”

NIH neuroscientist loses second paper, again the result of first author misconduct

Stanley Rapoport. Source: NIH
Stanley Rapoport. Source: NIH

Stanley Rapoport, a neuroscientist in the National Institute on Aging, isn’t having a lot of luck with his first authors. One committed misconduct and cost him a paper in the journal Age last year, and now he’s lost another paper with a different first author, but for the exact same reason.

The latest paper, in Neurochemical Research, examined whether chronic doses of aspirin reduce brain inflammation. It has been cited 14 times, according to Thomson Scientific’s Web of Knowledge.

Here’s more from the note: Continue reading NIH neuroscientist loses second paper, again the result of first author misconduct

Author from China blames translation company for plagiarism in retracted vascular paper

apjcpDo we need a “throwing vendors under the bus” category here at Retraction Watch?

Earlier this year, we reported on the retraction of a paper because of sloppy work by an outside lab. Now, we have the story of a retraction for “negligence” by a translator. Specifically, the author says the passages shared between the retracted 2015 vascular paper and another paper in EMBO Journal are a result of “negligence on the part of the translation company that I trusted to make my manuscript ready for submission.”

Here’s more from the notice in the Asian Pacific Journal of Cancer Prevention, written by Yong Jiang, of Laboratory Medical College, Jilin Medical College, China: Continue reading Author from China blames translation company for plagiarism in retracted vascular paper

Biology team with two retractions now correcting references to nixed papers

Screen Shot 2015-04-14 at 5.59.20 PMA team of biologists that retracted two papers after being “unable to replicate some of the results obtained by the first author of the paper” has now issued a correction to fix references to the two sunk publications.

The corrected paper is a review in the Journal of Virology — known there as a Gem — which discusses how viruses use the membranes of endoplasmic reticulum (ER) to replicate.

The two retractions were not signed by their first author, Riccardo Bernasconi, who won the STSBC-Roche Diagnostics award for one of the papers in 2012. The correction carries all three authors’ names, including Bernasconi’s (as second author).

Here’s more from the correction for “How Viruses Hijack the ERAD Tuning Machinery”: Continue reading Biology team with two retractions now correcting references to nixed papers

Cancer team loses two papers for image manipulation

bba_2A team spread across multiple institutions in China and McGill University in Canada has retracted two cancer papers over “inaccurate and inappropriately processed Western Blots.”

Some of the figures were also reused between the two articles, both in Biochimica et Biophysica Acta General Subjects.

The articles both tested the cancer-fighting properties of a derivative of the active compound present in Boswellia serrata gum resin.

Continue reading Cancer team loses two papers for image manipulation

Nature retracts epigenetics paper by author who lost two Science papers last year

cover_natureFrank Sauer, formerly of the University of California, Riverside, has had a 2002 letter on epigenetics retracted from Nature due to “inappropriate image manipulation.”

Sauer had two papers retracted from Science last year following a university investigation. Here’s the Nature notice for “Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1:” Continue reading Nature retracts epigenetics paper by author who lost two Science papers last year

Investigations into Voinnet’s work announced; critic publishes original peer review

Olivier Voinnet
Olivier Voinnet

The story about Olivier Voinnet, a high-profile plant biologist whose work has fallen under scrutiny, continues to build momentum. Late last week, Voinnet’s employer and one of his funders announced they were investigating his work, and one of the peer reviewers of a soon-to-be-retracted paper has made her original report public.

Here’s the statement from CNRS, which funds Voinnet: Continue reading Investigations into Voinnet’s work announced; critic publishes original peer review

Two more retractions bring lab break-in biochemist up to eleven

bbrcKarel Bezouška, the Czech biochemist who was caught on hidden camera breaking into a lab fridge to fake results, has turned it up to eleven with two new retractions.

Both retractions appeared in Biochemical and Biophysical Research Communications, one in October 2014 and one in January 2015.  His story began two decades ago in 1994, when he published a paper in Nature that couldn’t be reproduced, and was eventually retracted in 2013.

The best part of the story, of course, is that when his university was attempting to recreate his experiments, Bezouška broke into a lab fridge to tamper with the experiments. Unbeknownst to him, he was caught on hidden camera.  Continue reading Two more retractions bring lab break-in biochemist up to eleven