Category: molecular biology

Authors pull 14-year-old paper from PNAS over concerns of fabrication

13.coverAuthors have retracted a 2002 paper from PNAS because part of a figure “may have been fabricated,” and they no longer have the original data to prove otherwise.

The paper in question, “Deficient Smad7 expression: A putative molecular defect in scleroderma,” studied the signaling pathways that may underlie the autoimmune disease. It has been cited 198 times, according to Thomson Reuters Web of Science.

The authors, led by Pascal J Goldschmidt-Clermont, currently the Dean of the School of  Medicine at the University of Miami, have issued a retraction note, which appeared online yesterday: Continue reading Authors pull 14-year-old paper from PNAS over concerns of fabrication

Cancer researcher earns 9th retraction, for image duplication

Journal of Clinical InvestigationAlfredo Fusco, a researcher in Italy who has been under criminal investigation for scientific misconduct, has earned his ninth retraction.

Retraction number nine, by The Journal of Clinical Investigation, is for duplicating data from another publication — which has also faced questions on PubPeer about image manipulation, along with many other papers by Fusco.

The retraction note for “The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells” explains that the journal is pulling the paper even though the authors claim that they can reproduce the data:

Continue reading Cancer researcher earns 9th retraction, for image duplication

Poop paper flushed due to possible sample contamination

cover (3)The authors of a paper on a new probiotic strain of bacteria found in pig feces have retracted it from Animal Science Journal after discovering some of the bacteria might have been contaminated.

Readers likely know by now how easy it is for this to happen, as we frequently report on retractions due to similar reasons. Like other instances of mistaken cell identity, the authors of this 2013 paper realized the mistake following further tests of the bacteria used in the experiment.

The retraction for “Isolation, characterization, and effect of administration in vivo, a novel probiotic strain from pig feces”

Continue reading Poop paper flushed due to possible sample contamination

Mystery conflict between authors fells molecular bio paper

mirna-journal-coverA journal has pulled a paper about tools to knock out a key transcription factor because of a conflict between the authors.

The retracted article is “Generation of Knock down Tools for Transcription Factor 7-like-2 (TCF7L2) and Evaluation of its Expression Pattern in Developing Chicken Optic Tectum,” published just last year in MicroRNA.

We’ll get right to the reason — the retraction note provides one short one:

Continue reading Mystery conflict between authors fells molecular bio paper

Sperm paper impaired by “corporate company” analysis

2.coverWithout a certain protein, mouse sperm have motility disorders. That’s the conclusion of a paper that has itself been stopped — by errors in the data analysis, carried out by a third-party company.

The retraction note pins the analysis, which led to faulty data, on a “corporate company.” Aside from the companies that sell the kits used for substrates, assays, and detection, there’s only one company mentioned in the paper:

Generation of the mouse model was performed by the Cyagen Company (Guangzhou, China)

However, a representative of Cyagen says it does not offer the type of analysis described by the retraction note.

Here’s the full retraction note for the 2015 paper in Biology of Reproduction (which is paywalled — tsk, tsk):
Continue reading Sperm paper impaired by “corporate company” analysis

Authors retract striking circadian clock finding after failing to replicate

Screen Shot 2016-03-02 at 9.29.28 AMThe authors of a paper showing a “striking and unanticipated” relationship between light and temperature in regulating circadian rhythms are retracting it when the results couldn’t be replicated.

After being contacted by another group who couldn’t reproduce the data, the authors failed to, as well. They “have absolutely no explanation for the discrepancies with the original results,” according to the note in PLOS Biology.

It’s an unfortunate turn of events, but Continue reading Authors retract striking circadian clock finding after failing to replicate

Popular paper by famous longevity researcher gets mega-correction

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Leonard Guarente

A highly cited paper by a well-known scientist at the Massachusetts Institute of Technology who studies longevity could have aged better: The ten-year-old paper has earned its second correction.

It’s one of multiple papers by lead author Leonard Guarente that have been questioned on PubPeer. Guarente has already retracted one, and plans to address another. Continue reading Popular paper by famous longevity researcher gets mega-correction

Stem cell researcher in Spain dismissed following investigation

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Susana González

A promising early career researcher has been dismissed from her post at the National Center for Cardiovascular Research (CNIC) in Spain, following “an alleged ongoing fraud,” according to El Pais.

We don’t know what exactly the internal investigation into Susana González’s work found; El Pais relied on anonymous sources, and the CNIC confirmed only that they dismissed her on February 29th. There are allegations against her work on PubPeer, but we don’t know what role those played in the investigation.

(We had the story translated; here’s a PDF of the article in English.)

González denies that she committed misconduct, the paper reports:

Continue reading Stem cell researcher in Spain dismissed following investigation

Entire paper about cell division plagiarized

Chinese med jA paper about the role of specific proteins in the separation of newly replicated chromosomes is being retracted from the Chinese Medical Journal, after editors found out that the entire article was plagiarized.

The study, “MreBCD Associated Cytoskeleton is Required for Proper Segregation of the Chromosomal Terminus during the Division Cycle of Escherichia Coli,” names Feng Lu as the corresponding author and claims that the work was done in his lab at the Medical School of Henan University in Henan, China. The misappropriation came to light when a member of Lawrence Rothfield’s lab at the University of Connecticut saw the paper after it was published online last April, and realized that it was an exact replica of an unpublished paper that Rothfield’s own lab had produced.

Here’s the retraction note from the journal: Continue reading Entire paper about cell division plagiarized

Upon discovering several errors, authors retract gastric cancer paper

mmr_12_4After finding several errors in their paper about the molecular activity underlying gastric cancer, the authors unanimously decided to retract it.

According to the retraction note, three figures in the paper had β‑actin bands that were omitted, interchanged, or both.

The retraction note provides the details:

Continue reading Upon discovering several errors, authors retract gastric cancer paper