Authors defend publishing clinical trial six times, even as they earn two more retractions

Screen Shot 2015-09-30 at 12.14.06 PMIn August, we reported on a clinical trial on hundreds of hypertensive patients that was published six times. Now, copies published in Expert Opinion on Drug Safety and Journal of the American Society of Hypertension (JASH) have been retracted, making for a total of three retractions for the group of papers.

The authors have defended the papers as being decidedly “different,” but one of the latest retraction notes points to an earlier retraction by some of the same authors (including first author Giuseppe Derosa, at the University of Pavia in Italy) for publishing two papers that “contain considerable text that is duplicative.”

Inflammation editor in chief Bruce Cronstein, who retracted one of the six duplicated papers from the clinical trial, told us in August that he and the editors of the other journals were all contacted “en masse” by an author doing a Cochrane Review on hypertension, who noticed that all six papers were “nearly identical.”

Just recently, we received a statement from the authors — sent by corresponding author Derosa — which argued that even if six papers stem from one trial, each was decidedly “different:”

Continue reading Authors defend publishing clinical trial six times, even as they earn two more retractions

Much of preclinical research into one cancer drug is flawed, says report

elife-identity-headerA review of preclinical research of a now widely used cancer drug suggests the studies contain multiple methodology flaws and overestimate the benefits of the drug.

Specifically, the researchers found that most studies didn’t randomize treatments, didn’t blind investigators to which animals were receiving the drug, and tested tumors in only one animal model, which limits the applicability of the results. Importantly, they also found evidence that publication bias — keeping studies that found no evidence of benefit from the drug, sunitinib, out of the literature — may have caused a significant overestimation of its effects on various tumor types.

Together, these findings suggest the need for a set of standards that cancer researchers follow, the journal notes in a “digest” of the paper, published Tuesday by eLife:
Continue reading Much of preclinical research into one cancer drug is flawed, says report

Is less publishing linked to more plagiarism?

glogoCountries that publish less science appear to “borrow” more language from others than other, more scientifically prolific countries, according to a new small study.

Using a novel approach of comparing a country’s total citations against its total published papers (CPP), the authors categorized 80 retractions from journals in general and internal medicine. This is a relatively small number of retractions from one specific field of research; still, they found that:

Thus, retractions due to plagiarism/duplication were 3.4 times more likely among low-CPP countries than among high-CPP countries.

The CPP authors’ suggested interpretation? Continue reading Is less publishing linked to more plagiarism?

Elsevier retracting nine papers for fake peer review

elsevierThe fake peer review retraction count continues to mount.

Elsevier is retracting nine papers from five journals because fake email addresses for reviewers were provided during submission of the original manuscripts. According to a statement from the publisher: Continue reading Elsevier retracting nine papers for fake peer review

Nature: No plans to change wording of STAP retractions

cover_nature (2)Despite acknowledging in its own pages that two recent high-profile retraction notices turned out to not tell the whole story, Nature will not be updating the original retraction notices, the journal tells us.

We checked in with Nature after it published two Brief Communications Arising regarding two high-profile retractions of papers describing a new method of reprogramming cells to a pluripotent state. (This method is also known as stimulus-triggered acquisition of pluripotency, or STAP.)

We were particularly intrigued by the journal’s plans for the retractions, published in 2014, when an editorial in the September 23 issue about the new BCAs (here and here) suggested the wording of the notices might be problematic: Continue reading Nature: No plans to change wording of STAP retractions

Boldt’s retraction count upped to 94, co-author takes legal action to prevent 95th

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We’ve found two recent retractions and an expression of concern for Joachim Boldt, former prominent anesthesiologist and currently Retraction Watch leaderboard’s 2nd place titleholder. He now has 94 retractions.

One of the retracted articles contains falsified data, along with a researcher who didn’t agree to be a co-author, according to an investigation by the Justus Liebig University Giessen, where Boldt used to work. The expression of concern is regarding some questionable data. The other new retraction is actually one of 88 papers that a group of editors agreed to retract back in 2011, after they were “unable to verify” approval by the Institutional Review Board (IRB) for the studies.

One of those 88 papers, we’ve discovered, has still has not been retracted. According to an editor at the journal, they haven’t removed it because one of Boldt’s co-authors has threatened them with legal action. Continue reading Boldt’s retraction count upped to 94, co-author takes legal action to prevent 95th

13th retraction issued for Jesús Ángel Lemus

Proceedings of the Royal Society B- Biological SciencesA 13th retraction has been published for Jesús Ángel Lemus, the Spanish veterinary researcher whose work colleagues have had trouble verifying.

This paper was pulled for similar reasons as his other retractions: After retrying the experiments in two independent labs, fellow authors were “unable to arrive to any sound conclusion about the validity of his analyses.” 

Proceedings of the Royal Society B: Biological Sciences posted the notice September 16, three years after the paper received an expression of concern.

The retraction notice, signed by every co-author but Lemus, reads:

Continue reading 13th retraction issued for Jesús Ángel Lemus

Authors pull Science paper on molecular wires for “inappropriate data handling”

pic.mag.current-issueThis week’s issue of Science includes a retraction of a highly cited paper about manipulating the current in a string of molecules with a magnet, after an investigation by the co-authors revealed “inappropriate data handling” by the first author.

According to the note, the co-authors’ suspicions arose when they tried to follow-up on the data. Following a “thorough investigation,” they concluded that first author Rabindra N. Mahato had handled the data in such a way that they could no longer trust the conclusions. In the end, Mahato agreed to the retraction.

Here’s more from the note: Continue reading Authors pull Science paper on molecular wires for “inappropriate data handling”

So you want to be a whistleblower? Part III

John Thomas
John Thomas

This is the third and final article in a series by John R. Thomas, Jr., a lawyer at Gentry Locke [Editor’s note, 3/26/19: He has since moved to Haley, Hafemann, Magee and Thomas] who represents whistleblowers in a variety of False Claims Act cases.  His first article discussed the background of the False Claims Act (“FCA”) and how it might apply to scientific misconduct, and his second article provided advice on how to know if you have a viable FCA case. In this installment, he writes about the procedure for bringing an FCA case and how the damages and whistleblower’s share are calculated.

Suppose you are a potential whistleblower. You believe that your PI is manipulating data in publications. You suspect that a fellow lab technician is tampering with experiments. You are a PI who knows that your colleague is “double dipping” on Federal grants. What should you do? Continue reading So you want to be a whistleblower? Part III

Authors “did not have permission” to use pesticide data

10661An environmental journal is retracting an article about the risks of pesticides to groundwater after determining it contained data that “the authors did not have permission (implicit or explicit) to publish.”

According to the retraction note in Environmental Monitoring and Assessment, the paper said the data came from a non-author’s PhD thesis, but it’s not there. Those mysterious data were used to validate a model for pesticide exposures, described in an excerpt from the abstractContinue reading Authors “did not have permission” to use pesticide data