Category: not reproducible

Two more retractions bring lab break-in biochemist up to eleven

bbrcKarel Bezouška, the Czech biochemist who was caught on hidden camera breaking into a lab fridge to fake results, has turned it up to eleven with two new retractions.

Both retractions appeared in Biochemical and Biophysical Research Communications, one in October 2014 and one in January 2015.  His story began two decades ago in 1994, when he published a paper in Nature that couldn’t be reproduced, and was eventually retracted in 2013.

The best part of the story, of course, is that when his university was attempting to recreate his experiments, Bezouška broke into a lab fridge to tamper with the experiments. Unbeknownst to him, he was caught on hidden camera.  Continue reading Two more retractions bring lab break-in biochemist up to eleven

Stats error has chilling effect on global warming paper

global change biologyIt turns out a 2014 paper that found a surprising pattern of plant migration in response to global warming was not so surprising after all — it’s been retracted by the authors due to a mistake in the statistical analysis.

Most studies on migrating populations have found that species around the globe move north to escape the rising temperatures. But the authors of the 2014 paper in Global Change Biology found the opposite — according to their analysis, many plant species in Western North America had been migrating south, toward warmer climates.

The lead author Melanie Harsch told Science in 2014 that the team had been suspicious of the analysis, and so ran it twice: Continue reading Stats error has chilling effect on global warming paper

Drug paper gets a fix, notching several corrections

rsc_tb_1_3_COVER.inddThe Journal of Materials Chemistry B has issued a laundry list of corrections for a 2014 chemotherapy paper, which address re-use of “some text”, incorrectly stated doses, and miscalculations of the drug concentration, among other issues.

The paper described a new way to deliver gemcitabine via nanoparticles, focusing the drug on the tumors.

It turns out the authors’ focus wasn’t so clear when writing the paper. The researchers, at the Chinese Academy of Medical Science, Peking Union Medical College, and Tianjin University in China, said they used “some text” from two 2013 papers by a team of French oncologists “without appropriate attribution,” as well as repeatedly getting the in vivo dose wrong. The manuscript also contained several incorrect calculations of the “drug loading,” or the proportion of active drug.

Here’s the correction for “Tailor-made gemcitabine prodrug nanoparticles from well-defined drug–polymer amphiphiles prepared by controlled living radical polymerization for cancer chemotherapy” (free, but requires sign-in): Continue reading Drug paper gets a fix, notching several corrections

Cabbage batch skids: new experiments dry up plant paper

current biologyProminent plant researcher Mark Estelle has retracted a paper on plant hormones after follow-up studies showed the conclusions were incorrect.

The hormone in question, auxin, is a major player in plant growth and development. The retracted Current Biology paper reported that a certain auxin receptor, designated AFB4, downregulates the responses of cabbage-cousin Arabidopsis thaliana to the signaling molecule. But after publication, the researchers experimented with a mutant seedling that didn’t produce the receptor, and discovered it didn’t overreact to auxin signals, indicating the receptor wasn’t playing a major role in limiting the effects.

Estelle, a Howard Hughes Medical Institute investigator based at the University of California, San Diego, told us he and his team are working on a paper that will contain the accurate data from the paper, along with new findings.

Here’s the notice for “The AFB4 Auxin Receptor Is a Negative Regulator of Auxin Signaling in Seedlings”, which has 62 citations, per Google Scholar: Continue reading Cabbage batch skids: new experiments dry up plant paper

Sticky situation: Paper using honey for healing pulled over data issues

honey
Image via Hillary Stein

A paper on dressing wounds with honey has been retracted after the journal realized that an outlier patient was throwing off the data analysis.

Honey has been used for millennia as an antimicrobial wound dressing. Doctors can even buy sterile preparations of the sweetener. But the evidence that honey is better than other wound dressings is still inconclusive.

According to the retracted paper, published in International Wound Journal in 2008, Manuka honey has an acidic pH which helps reduce the alkaline environment of chronic woulds. Indeed, the authors found that Manuka honey dressings lowered wound pH and reduced wound size.

Sadly, the paper was pulled in 2014, after someone realized one patient had a particularly large wound that was throwing off statistics. The injury was 61 cm^2 at the beginning of the study, while the others ranged from .9 to 22 cm^2. After removing that patient from the analysis, the results no longer held up.

Continue reading Sticky situation: Paper using honey for healing pulled over data issues

Frontiers lets HIV denial article stand, reclassifies it as “opinion”

frontiers phFollowing an investigation sparked by criticism for its decision to publish a paper questioning the link between HIV and AIDS, a Frontiers journal has decided to not retract the article but rebrand it as an “opinion.”

In September, 2014, Patricia Goodson, a professor of health education at Texas A&M University, published an article called “Questioning the HIV-AIDS hypothesis: 30 years of dissent.”

The paper was quickly called into question, and the journal, Frontiers in Public Health, issued a statement of concern and promised to look into the problem. Now, they’ve announced their solution: call the paper an “opinion” and publish an argument against it.

Continue reading Frontiers lets HIV denial article stand, reclassifies it as “opinion”

Harvard-Smithsonian space center retracts ruling on asteroid

Image of near Earth astroid Ida, via NASA
Image of main-belt asteroid Ida, via NASA

Between Mars and Jupiter floats a little rock with big dreams.

For three whole weeks in January and February, it was designated as 2015 BS515, a near Earth object, one of the many space rocks that astrophysicists keep an eye on for their potential to strike our planet. But then on February 12 came the announcement: the Minor Planet Center (MPC) at the Harvard-Smithsonian Center for Astrophysics had downgraded the rock to a “routine main-belt object.” That means the asteroid is far enough away that we don’t have to worry about it hitting Earth any time soon.

The MPC gets sent two million observations of asteroids and comets every month. The five staff members then catalog these findings and figure out what’s new and what’s been seen before. The goal is to keep track of all near Earth objects, which make up about 1% of the observations the Center receives. It’s remarkable that there are so few corrections, given the 120 million observations on the MPC’s books.

Here’s a portion of the note that appeared in the most recent Minor Planet Electronic Circular (MPEC), which provides updates about comets, “observable unusual objects,” and other asteroid news: Continue reading Harvard-Smithsonian space center retracts ruling on asteroid

Cry me a retraction: Scientists pull Cry protein paper for irreproducibility

world journal of microbialA paper on the biological insecticide Cry protein — most famously produced by genetically modified “Bt” corn — has been retracted because the authors couldn’t reproduce the findings.

The initial paper concluded that their modified gene produced a Cry protein that was significantly more toxic than the one currently spliced into food crops to make them resistant to moths, beetles, and other insects. However, when repeating the experiments, the modified proteins weren’t any more deadly than the original version.

Here is the notice: Continue reading Cry me a retraction: Scientists pull Cry protein paper for irreproducibility

Chem paper retracted because “a significant amount of data” was wrong

Jced_coverThe editors of ACS’s Journal of Chemical and Engineering Data have sunk a paper on halogenated alkanes after realizing that “a significant amount” of the data was “inaccurate,” thereby “invalidating” the paper.

Here’s the notice for “Influence of Solvent Nature on the Solubility of Halogenated Alkanes” (which has only been cited twice, according to Google Scholar): Continue reading Chem paper retracted because “a significant amount of data” was wrong

Can’t spell Novartis without VART: Drug study retracted for conflict of interest, data issues

JHH(Cover).inddA major scandal in Japan over the Novartis hypertension drug valsartan has resulted in a retraction from the Journal of Human Hypertension. 

Frequent Retraction Watch subject Hiroaki Matsubara resigned his post at Kyoto Prefectural University in 2013, after his work on valsartan was shown to be riddled with data errors and undisclosed conflicts of interest.

Also that year, suspicions about Chiba University hypertension researcher Issei Komuro’s work were first raised by an anonymous blog, which detailed numerous image manipulations in the researcher’s published works. Komuro, who frequently collaborated with Matsubara, has been a senior author on a number of valsartan papers, including the now-retracted one, which reported the results of Novartis-sponsored Valsartan Amlodipine Randomized Trial in 2011 without reporting the Novartis funding.

The paper, which has been cited three times, according to Thomson Scientific’s Web of Knowledge, had already been subject to a correction in 2013:  Continue reading Can’t spell Novartis without VART: Drug study retracted for conflict of interest, data issues