Category: doing the right thing

“[T]hese things can happen in every lab:” Mutant plant paper uprooted after authors correct their own findings

FrontiersThree biologists at Tokyo Gakugei University in Japan have retracted a 2014 Frontiers in Plant Science paper on abnormal root growth in Arabidopsis “in light of new experimental evidence” showing they fingered the wrong mutant gene. The journal editors are hailing the retraction as an “excellent example of self-correction of the scientific record.”

The paper, “Mechanosensitive channel candidate MCA2 is involved in touch-induced root responses in Arabidopsis,” described the abnormally behaving roots of a mca2-null mutant Arabidopsis plant.

A subsequent string of experiments by the same research team—including DNA microarrays, RT-PCR, and a PCR-based genomic deletion analysis—demonstrated that two other mutations that somehow creeped into their experimental populations may have been to blame for the abnormal root behavior.

It’s a notably thorough and informative retraction notice from Frontiers, an open-access publisher with a history of badly handled and controversial retractions and publishing decisions. The notice describes the new experiments and the previous, erroneous results: Continue reading “[T]hese things can happen in every lab:” Mutant plant paper uprooted after authors correct their own findings

Chip slip: Irreproducibility erases computer memory paper

nanoscaleResearchers at the Chinese Academy of Sciences have retracted a paper in Nanoscale about an experimental computer chip after they were unable to recreate their published results.

“We retract this article to avoid misleading readers and intend to undertake further tests to confirm our previous results,” they write in the notice.

The scientists are working on developing a chip that uses resistive random-access memory, which allows a huge amount of information to be stored in a tiny package and accessed quickly while using very little power. A number of companies are working on the technology, but none have successfully commercialized it.

Here’s the notice for “High uniformity and improved nonlinearity by embedding nanocrystals in selector-less resistive random access memory” (free, but requires login): Continue reading Chip slip: Irreproducibility erases computer memory paper

The “worst moment of my scientific career:” Two bird migration articles brought down by analytical error

JAvianBio_ak19Evolutionary and conservation biologists in Spain are retracting two articles – one from the Journal of Avian Biology and the other from Ardeola – because they discovered a fatal flaw in their analysis.

The Journal of Avian Biology article, “Are European birds leaving traditional wintering grounds in the Mediterranean?” aimed to determine whether the abundance of passerines had decreased in recent decades, but failed to control for birds that may have gotten killed by hunters. Although it was published in January, we can only find an abstract from its acceptance by the journal in November 2014.

The authors detail the saga of their error in the retraction notice: Continue reading The “worst moment of my scientific career:” Two bird migration articles brought down by analytical error

PNAS paper on dengue virus pulled due to contamination

PNAS_ak11smThe authors of a paper on dengue virus vaccine design published last year in PNAS are retracting it after discovering that their experimental dengue virus was contaminated.

Although they are confident that the strategy is sound, the authors write in their commendably detailed retraction notice that the “inadvertent error” rendered the results “uninterpretable.”

Here’s the retraction notice: Continue reading PNAS paper on dengue virus pulled due to contamination

Teflon toxicity paper fails to stick

toxicological sciencesAn advanced online paper on prenatal toxicity of perfluorooctanoic acid (PFOA), an industrial chemical used to make waterproof coatings and Teflon, is being retracted due to “some minor errors.”

High blood levels of PFOA have been tied to kidney disease in humans, as well as several cancers in animal models. The majority of the U.S. Environmental Protection Agency’s scientific advisory board deemed PFOA “likely to be carcinogenic in humans” in 2006, though a decade later the EPA has yet to make a decision on regulations. The retracted paper found that exposing pregnant mice to PFOA altered hormone pathways in mammary glands.

According to the notice in Toxicological Sciences, there was a duplicated image in one of the figures, as well as “some minor errors.” Here’s figure 5B: Continue reading Teflon toxicity paper fails to stick

Molecular mixup burns chemistry paper

advanced synthesis and catalysisChemists at Lanzhou University in China did the right thing last month, retracting a paper in Advanced Synthesis & Catalysis because of issues with a reactant that could only be corrected by changing “all the text and quantities.”

When the scientists were adding what was labeled Reactant 1 to the mix, they believed it was α-ethoxycarbonyl-α-azido-N-phenylacetamides. Unfortunately, what they were actually using was a decomposed version of the molecule, which threw everything off.

Here’s the notice for “tert-Butyl Hydroperoxide and Tetrabutylammonium Iodide- Promoted Free Radical Cyclization of α-Azido-N-arylamides”: Continue reading Molecular mixup burns chemistry paper

Retraction and republication for Lancet Resp Med tracheostomy paper

lancetrmA paper whose expression of concern we covered in November 2014 has been retracted and republished “because of the extent of the changes necessary,” according to the Lancet Respiratory Medicine.

This isn’t the first time we’ve seen retraction/republications at the Lancet, accompanied by thorough breakdowns of the problem.

This study was a meta-analysis of research on how the timing of tracheostomies — placing a breathing tube directly into the windpipe — affects patients’ mortality rate. The original paper found that critically ill patients who received a tracheostomy earlier fared better than those for whom the procedure was delayed for weeks after intubation, the recommended practice.

However, when the authors calculated how many patients died, they assumed that any patient who wasn’t discharged from the intensive care unit (ICU) had died there, instead of looking for other explanations. This made their estimates unreliable.

The publisher convened a panel, which ultimately decided retraction and republication was the most appropriate course of action.

The original expression of concern contained a quote from the authors about the “data discrepancy” that would later sink the paper: Continue reading Retraction and republication for Lancet Resp Med tracheostomy paper

Slippery slope? Data problems force retraction of landslide paper

The Mameyes Landslide, in Puerto Rico, buried more than 100 homes in 1985. Source: USGS
The Mameyes Landslide, in Puerto Rico, buried more than 100 homes in 1985. Source: USGS

The authors of a 2014 paper in The Scientific World Journal on rock slopes have retracted their article for “erroneous” data.

The paper, “Slope Stability Analysis Using Limit Equilibrium Method in Nonlinear Criterion,” came from a group of researchers from institutions including the Changjiang River Scientific Research Institute in Wuhan, and the Key Laboratory of Transportation Tunnel Engineering at Southwest Jiaotong University in Chengdu. It’s about (we think) how to calculate the safety of rock slopes, and how vulnerable they are to landslides.

Here’s the notice, which as a pretty fair ratio of words to information:

Continue reading Slippery slope? Data problems force retraction of landslide paper

“Serious and obvious mistakes” kill paper on heart attacks in rats

j card pharmA group of researchers in China and the United States have retracted a 2014 paper in the Journal of Cardiovascular Pharmacology after discovering the data were fatally flawed.

The article examined whether the anti-arrhythmia drug zacopride affected cardiac remodeling after heart attack, and came from Bo-We Wu, of Shanxi Medical University, in Taiyuan, and colleagues, including one author from Savannah, Georgia.

Here’s more from the notice for “Activation of IK1 channel by zacopride attenuates left ventricular remodeling in rats with myocardial infarction”:

Continue reading “Serious and obvious mistakes” kill paper on heart attacks in rats

Cabbage batch skids: new experiments dry up plant paper

current biologyProminent plant researcher Mark Estelle has retracted a paper on plant hormones after follow-up studies showed the conclusions were incorrect.

The hormone in question, auxin, is a major player in plant growth and development. The retracted Current Biology paper reported that a certain auxin receptor, designated AFB4, downregulates the responses of cabbage-cousin Arabidopsis thaliana to the signaling molecule. But after publication, the researchers experimented with a mutant seedling that didn’t produce the receptor, and discovered it didn’t overreact to auxin signals, indicating the receptor wasn’t playing a major role in limiting the effects.

Estelle, a Howard Hughes Medical Institute investigator based at the University of California, San Diego, told us he and his team are working on a paper that will contain the accurate data from the paper, along with new findings.

Here’s the notice for “The AFB4 Auxin Receptor Is a Negative Regulator of Auxin Signaling in Seedlings”, which has 62 citations, per Google Scholar: Continue reading Cabbage batch skids: new experiments dry up plant paper