Category: plos

Leading diabetes researcher corrects paper as more than a dozen studies are questioned on PubPeer

maelder
Kathrin Maedler

Prominent German diabetes researcher Kathrin Maedler has issued corrections on two papers, and told Retraction Watch she is in the process of defending the data on others.

14 of her papers have been critiqued by PubPeer commenters. The commentary, which spans from her graduate work in 2002 to a 2014 publication in Nature Medicine, includes questions about image manipulation and self-plagiarism.

Laborjournal’s blog (we have a column in their English-language publication) first flagged these suspicions in July 2014, after being approached by pseudonymous Clare Francis.

Here’s a comparison between figures in Maedler’s 2009 PLoS One paper, “Deletion of the Mitochondrial Flavoprotein Apoptosis Inducing Factor (AIF) Induces β-Cell Apoptosis and Impairs β-Cell Mass,” and one she co-authored in 2006 in Diabetes, “Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets,” via PubPeer:  Continue reading Leading diabetes researcher corrects paper as more than a dozen studies are questioned on PubPeer

PLOS Genetics investigating paper by Ariel Fernandez

Ariel Fernandez, via Wikipedia
Ariel Fernandez, via Wikipedia

Ariel Fernandez‘s list of papers with editorial asterisks next to them grew again this week.

Fernandez has had one paper retracted, two papers subject to Expressions of Concern, including one from Nature, and another put on hold over data concerns. He threatened to sue us for covering one of the Expressions of Concern.

Here’s the “Notice from PLOS Genetics” for “Protein Under-Wrapping Causes Dosage Sensitivity and Decreases Gene Duplicability:”

Please be advised that PLOS is working with the authors on an investigation regarding one or more issues that have been raised with respect to the content or authorship of this paper.

We asked Fernandez for more details. He did not provide any, saying only that the criticisms of the work “have no scientific value” because they were made anonymously: Continue reading PLOS Genetics investigating paper by Ariel Fernandez

“Incorrect data” kills apoptosis paper

Screen Shot 2014-12-19 at 5.52.16 PMFrontiers in Pharmacology has retracted a paper on baicalin, an antioxidant sold in health food stores, because it had both “incorrect data and invalid statistical analyses.”

A comment on PubPeer notes that one of the figures (see image to the right) contains two similar-looking flow cytometry images labeled with different values, which could be what the retraction is hinting at.

Here’s the notice for “Baicalin induced dendritic cell apoptosis in vitro”: Continue reading “Incorrect data” kills apoptosis paper

Heart journal pulls paper for image manipulation

cardresCardiovascular Research has retracted a 2010 paper by a group of prominent cardiology researchers in Brazil.

The reason: Image manipulation — which the authors say didn’t materially affect the conclusions of the paper.

The article, “FAK mediates the activation of cardiac fibroblasts induced by mechanical stress through regulation of the mTOR complex,” came from a group led by Ana Paula Dalla Costa, from the State University of Campinas.

Here’s the abstract of the study, which has been cited 19 times, according to Thomson Scientific’s Web of Knowledge: Continue reading Heart journal pulls paper for image manipulation

Cell line switch sinks PLoS ONE cancer paper

plosWe’ve written before about how common cell line mix ups are in cancer research; according to a 2012 Wall Street Journal article (paywalled), between a fifth and a third of cancer cell lines tested by suspicious researchers turned out to be misidentified.

Obviously, mistakenly studying the wrong kind of cancer is a waste of precious resources, both time and money. And it’s clear the problem hasn’t gone away. PLoS ONE just retracted a cancer paper originally published in December 2012 for studying two cell lines that had been contaminated by other cell types.

Here’s the notice for “Epithelial Mesenchymal Transition Is Required for Acquisition of Anoikis Resistance and Metastatic Potential in Adenoid Cystic Carcinoma”:
Continue reading Cell line switch sinks PLoS ONE cancer paper

Data questions prompt retraction of PLOS ONE cardiovascular paper

plosonePLoS One has retracted a 2013 article on atherosclerosis in mice over concerns about the integrity of the data.

The paper, “The Effect of Soluble RAGE on Inhibition of Angiotensin II-Mediated Atherosclerosis in Apolipoprotein E Deficient Mice,” came from a group of researchers in South Korea.

It purported to show that: Continue reading Data questions prompt retraction of PLOS ONE cardiovascular paper

Sampling the wrong part of the aorta sinks aneurysm paper

plosoneA paper on an experimental treatment for abdominal aneurysms has been retracted after it was discovered samples had been taken from the wrong part of the aorta.

Here is the PLOS ONE notice for “Inhibition of Rho-Kinase by Fasudil Suppresses Formation and Progression of Experimental Abdominal Aortic Aneurysms:” Continue reading Sampling the wrong part of the aorta sinks aneurysm paper

PLOS ONE retraction notice blames deceased author for image manipulation

A 2011 paper in PLOS ONE has been retracted due to “inappropriately assembled” images. The issues, which were highlighted in a correction in TK, are attributed to the corresponding author, Paola Palozza, who has since passed away.

Here’s the notice for “Lycopene Inhibits NF-kB-Mediated IL-8 Expression and Changes Redox and PPARγ Signalling in Cigarette Smoke–Stimulated Macrophages,” which has been cited 33 times, according to Thomson Scientific’s Web of Knowledge: Continue reading PLOS ONE retraction notice blames deceased author for image manipulation

Authors of three retracted PLOS ONE papers to retract four more, with one researcher resigning

ChemosphereThe hits keep coming for a research group at the Institute of Microbial Technology (IMTECH) in Chandigarh, India.

Last week, we reported that PLoS ONE was retracting three papers by the research group because “there are no data available underlying this study and thus…the published results are fabricated.” Now, according to The Hindu, four more papers are being retracted:
Continue reading Authors of three retracted PLOS ONE papers to retract four more, with one researcher resigning

PLOS ONE retracts breast cancer genetics paper after claim of misappropriated data

plosonePLOS ONE has retracted a 2012 article by a group of breast cancer researchers after another scientist — a leading U.S. oncologist — objected that the data came from his lab.

The paper, “GREB1 Functions as a Growth Promoter and Is Modulated by IL6/STAT3 in Breast Cancer,” came from a team composed of researchers at the Morehouse School of Medicine, Xavier University of Louisiana and the University of Miami School of Medicine. It purported to find that: Continue reading PLOS ONE retracts breast cancer genetics paper after claim of misappropriated data