Category: by journal

Nature journal retracts controversial CRISPR paper after authors admit results may be wrong

Nature Methods has retracted a 2017 paper suggesting a common gene editing technique may cause widespread collateral damage to the genome.

The notice has a long backstory: After the paper was published, it immediately drew an outcry from critics (including representatives from companies who sell the tool, whose stock fell after publication). Some critics argued that the authors, led by Vinit B. Mahajan at Stanford University, hadn’t employed sufficient controls, so they couldn’t be sure that the observed mutations stemmed from the tool, rather than normal background variation between mice. Only months after the paper appeared, the journal issued an expression of concern about the article. In a new preprint posted on BioRxiv on Monday, the authors concede that their critics may be right.

In the new preprint, Mahanjan and his colleagues acknowledge that the gene editing technique — known as CRISPR-Cas9 — “may not introduce numerous, unintended, off-target mutations.”

However, according to the retraction notice, Mahajan and several of his co-authors object to the retraction: Continue reading Nature journal retracts controversial CRISPR paper after authors admit results may be wrong

Caught Our Notice: Duplicates, errors prompt two retractions for same author

Titles: 1) Angiopoietin-Like 4 Confers Resistance to Hypoxia/Serum Deprivation-Induced Apoptosis through PI3K/Akt and ERK1/2 Signaling Pathways in Mesenchymal Stem Cells

2) Novel Mechanism of Inhibition of Dendritic Cells Maturation by Mesenchymal Stem Cells via Interleukin-10 and the JAK1/STAT3 Signaling Pathway

What Caught Our Attention: In the span of 48 hours, PLOS ONE retracted two papers this month that were co-authored by Bo Yu, based at Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment and The Second Affiliated Hospital of Harbin Medical University in China. Both notices cite multiple duplications and errors, and conclude:

Continue reading Caught Our Notice: Duplicates, errors prompt two retractions for same author

PNAS wouldn’t let authors cite unpublished manuscript. Now, it admits it was wrong.

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When researchers submitted a paper about a type of microparticle to PNAS, they wanted to give credit where it was due, and cite an unpublished manuscript that helped guide their work. But the journal’s policy forbid citing unpublished work, and the reference was removed before publication. Now, concerns from the authors of that unpublished work have prompted the journal to have a change of heart.  

Continue reading PNAS wouldn’t let authors cite unpublished manuscript. Now, it admits it was wrong.

“Absolutely mortified” after unintentionally plagiarizing, author offers to step down from new post

A few months ago, Dirk Werling discovered he had made a horrible mistake: He had inadvertently plagiarized in his recent review.

On January 20, Werling said he came across a 2016 paper while working on a grant and realized he had published some of the text in his 2018 review in Research in Veterinary Science. Werling — based at Royal Veterinary College at the University of London — told Retraction Watch:

I knew I needed to retract my paper.

Continue reading “Absolutely mortified” after unintentionally plagiarizing, author offers to step down from new post

Caught Our Notice: Yes, a 20-year-old article is wrong — but it won’t be corrected online

Title: AMPA receptor-mediated regulation of a Gi-protein in cortical neurons

What Caught Our Attention:  Usually, when journals publish corrections to articles, they also correct the original article, except when the original is unavailable online.  When Nature noticed that some figure panels in a 20-year-old paper were duplicated, it flagged the issue for readers — but didn’t correct the online version of the original paper. According to the notice, the duplications don’t disturb the conclusion illustrated by the figure, the original data couldn’t be found, and the last two authors had retired. We contacted a spokesperson at Nature, who told us “the information at the start of the paper clearly links to the corrigendum.”   Continue reading Caught Our Notice: Yes, a 20-year-old article is wrong — but it won’t be corrected online

Paper used to support WHO guidelines on preventing infections “has no scientific validity”

A surgery journal retracted a 2014 paper last month after discovering that the study has “no scientific validity.”

Mario Schietroma and his coauthors, based at the University of L’Aquila in Italy, reported that giving patients high concentrations of oxygen during and after colorectal surgery significantly reduced their risk of infections. Although the authors reported significant p-values, the retraction notice states that, “upon recalculation, no p-values were close to significant.” The University of L’Aquila told Retraction Watch it is investigating, but did not provide details. Continue reading Paper used to support WHO guidelines on preventing infections “has no scientific validity”

Authors claim clinical trial data came from one center. It came from three.

A BMJ journal has retracted a 2017 paper that made a false claim about the clinical trial in question. 

The Acupuncture in Medicine paper reported the results of a clinical trial about the impact of acupuncture and Chinese herbal medicine on stroke, gathered from one center. However, in November, the editors of the journal discovered that the authors had completed the trial at three centers, and had already published the data in Scientific Reports in 2016. The authors say the duplication and misrepresentation of the data stemmed from “confusion and misunderstanding.” Continue reading Authors claim clinical trial data came from one center. It came from three.

Author: “The retractions were about bureaucracy, not science”

A researcher has retracted two 2014 papers, after discovering they had not gone through the proper approval process before being submitted.

The papers were part of a collaboration funded by the U.S. National Institutes of Health, which focused on solving protein structures. Adam Godzik, the senior author, told Retraction Watch that all papers had to be approved by a special committee before being submitted to a journal. Given the scale of the collaboration, the committee for the Joint Center for Structural Genomics (JCSG) would assess whether researchers who had made a previous contribution to the work should be added as authors.

Proteins: Structure, Function, and Bioinformatics retracted both papers after Godzik informed the editor in August 2014 that neither article had undergone the required review before being submitted to the journal. Although Wiley agreed to the retractions in an email to Godzik in September 2014,  the papers were only pulled in January—more than three years later. Continue reading Author: “The retractions were about bureaucracy, not science”

Caught Our Notice: “The first author cut the thermoprinter paper printout into pieces and reassembled them”

Title: A mitochondrial ferredoxin is essential for biogenesis of cellular iron-sulfur proteins

What Caught Our Attention: Here’s a cut-and-paste issue that gave us pause. The authors of an 18-year-old paper in PNAS corrected it after realizing some bands in a figure were duplicated (an issue raised on PubPeer one year ago). It turns out, the first author had cut the paper into pieces and reassembled them to present the blots in the “desired order,” and some had become duplicated by mistake. The overall results were unaffected, so the journal swapped the image with a corrected version. Continue reading Caught Our Notice: “The first author cut the thermoprinter paper printout into pieces and reassembled them”

Journal retracts study linking “gut makeover” to weight loss, improved health

Over the objections of the authors, PLOS ONE has retracted a paper linking a diet designed to restore healthy gut bacteria to weight loss and other benefits.

The study, published in June 2017, claimed to show that a “Microbiome restoration diet improves digestion, cognition and physical and emotional wellbeing.” The diet was one championed by The Gut Makeover, whose author, Jeannette Hyde, is also a co-author on the paper (which the paper clearly disclosed). The diet is “designed to improve the health and diversity of the microbiome,” the microbiota that live within us.

The paper apparently prompted some criticisms, and even led one academic editor at PLOS ONE to resign. The journal  now says “the conclusions of this study are not supported by the data presented,” and have retracted it. But the case may reveal more about the limitations of peer review at the journal than it does about any weaknesses of the study. Continue reading Journal retracts study linking “gut makeover” to weight loss, improved health