Category: lancet

Lancet issues expression of concern for 2011 Macchiarini paper

Paolo Macchiarini
Paolo Macchiarini

The Lancet has tagged an expression of concern onto a seminal 2011 paper by Paolo Macchiarini, the Italian surgeon whose work and conduct outside the operating room has earned months of  heavy criticism that recently culminated in his dismissal from the Karolinska Institutet.

“Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept study,” which described the first case of a transplant using an artificial trachea seeded with the patient’s own stem cells, now bears an expression of concern from The Lancet editors, citing ongoing investigations. The journal has also removed three more authors from the paper, upon their request.

The expression of concern essentially presents the timeline of the controversy that led the journal to make this move:

Continue reading Lancet issues expression of concern for 2011 Macchiarini paper

Top journals give mixed response to learning published trials didn’t proceed as planned

Ben Goldacre
Ben Goldacre

Ben Goldacre has been a busy man. In the last six weeks, the author and medical doctor’s Compare Project has evaluated 67 clinical trials published in the top five medical journals, looking for any “switched outcomes,” meaning the authors didn’t report something they said they would, or included additional outcomes in the published paper, with no explanation for the change. The vast majority – 58 – included such discrepancies. Goldacre talked to us about how journals – New England Journal of Medicine (NEJM), JAMA, The Lancet, BMJ, and Annals of Internal Medicine — have responded to this feedback.

Retraction Watch: When you discover a published trial has switched outcomes, what do you do? Continue reading Top journals give mixed response to learning published trials didn’t proceed as planned

Lancet retracts 24-year-old paper by “father of nutritional immunology” after reopening inquiry

lancetFollowing questions from outside experts, a retraction of a related paper, a university investigation and a court case, The Lancet has decided to retract a 1992 paper by Ranjit Kumar Chandra, the self-proclaimed “father of nutritional immunology.”

In a lengthy retraction note included in the January 30 issue, the journal explains that:

the balance of probabilities in our judgment is that the reliability of the 1992 Lancet paper by Chandra can no longer be assured.

Chandra is objecting to the retraction.

This retraction was a long time coming, so sit back and relax as we fill in the backstory. Continue reading Lancet retracts 24-year-old paper by “father of nutritional immunology” after reopening inquiry

Did a clinical trial proceed as planned? New project finds out

Ben Goldacre
Ben Goldacre

A new project does the relatively straightforward task of comparing reported outcomes from clinical trials to what the researchers said they planned to measure before the trial began. And what they’ve found is a bit sad, albeit not entirely surprising.

As part of The Compare Project, author and medical doctor Ben Goldacre and his team have so far evaluated 36 clinical trials published by the top five medical journals (New England Journal of Medicine, the Journal of the American Medical Association, The Lancet, Annals of Internal Medicine, and British Medical Journal). Many of those trials included “switched outcomes,” meaning the authors didn’t report something they said they would, or included additional outcomes in the published paper, with no explanation for the change.

Here are the latest results from the project, according to its website:

Continue reading Did a clinical trial proceed as planned? New project finds out

Nutrition researcher Chandra loses libel case against CBC

CBCThe self-proclaimed “father of nutritional immunology,” Ranjit Kumar Chandra, has lost a libel lawsuit against the Canadian Broadcasting Company (CBC).

The suit was in response to a 2006 three-part documentary from the CBC, which examined allegations of fraud against the former Memorial University researcher.

After the 58-day trial, the Ontario Superior Court of Justice “ruled in favour of CBC, on the grounds that the words in the broadcast were true,” according to CBC producer Lynn Burgess: Continue reading Nutrition researcher Chandra loses libel case against CBC

Macchiarini co-author objects to investigation’s misconduct verdict

dr-paolo-macchiarini
Paolo Macchiarini

One of Paolo Macchiarini’s co-authors on a 2011 Lancet paper describing an allegedly groundbreaking procedure to transplant an artificial trachea seeded with stem cells is objecting to a recent investigation that concluded Macchiarini had committed misconduct.

Ola Hermanson, who studies neural stem cells at Karolinska Institutet, argued in a report dated June 29 that the investigation contained “serious flaws and formal errors.”

Hermanson’s lengthy response (uploaded here except for supporting emails) is to the findings of an external review of allegations about Macchiarini’s work, conducted by Bengt Gerdin, of Uppsala University. In regards to the 2011 Lancet paper, Gerdin’s investigation found:

Continue reading Macchiarini co-author objects to investigation’s misconduct verdict

Lancet retracts and republishes cardiology paper with admirable notice

logo_lancetOne of the papers from a massive heart disease study in China, published in the Lancet, has been retracted and republished after the authors noticed a statistical error.

The article, by authors from Peking Union Medical College in China, Yale University, and elsewhere, presented the results of the China PEACE-Retrospective Acute Myocardial Infarction Study, part of a national initiative to study and improve care for cardiac problems. After being posted online on June 24, 2014, the authors noticed that they’d incorrectly weighed one of the cities in their calculations, which threw off a number of national estimates.

After the corrections were made, the paper was peer-reviewed again, and reviewers stated that despite the mistakes, the original conclusions were sound.

Today is a banner day on Retraction Watch: This is our second excellent example of transparency in 24 hours, and therefore the second entry in our “doing the right thing” category. An editorial lays out exactly what happened, including a timeline, allowing scientists to feel confident they’re basing the next research step on solid and accurate data. (We also appreciate the hat tip to the Committee on Publication Ethics retraction guidelines, which we often send out to editors of bad notices as a gentle reminder.)

Here’s the notice for “ST-segment elevation myocardial infarction in China from 2001 to 2011 (the China PEACE-Retrospective Acute Myocardial Infarction Study): a retrospective analysis of hospital data”: Continue reading Lancet retracts and republishes cardiology paper with admirable notice

Contrary to reports, Lancet not retracting controversial letter to people of Gaza

logo_lancetDespite the claims of a widely circulated news report today, The Lancet has no plans to retract a controversial open letter to the people of Gaza that has drawn criticism since being published in August.

The Jewish Telegraphic Agency (JTA) reported this morning: Continue reading Contrary to reports, Lancet not retracting controversial letter to people of Gaza

Harvard-Brigham heart researcher under investigation earns Lancet Expression of Concern

logo_lancetOn Tuesday, we broke the news of the retraction in Circulation of a paper on cardiac stem cells by a group of researchers being investigated by Harvard Medical School and the Brigham and Women’s Hospital. Today, The Lancet has issued an Expression of Concern about another paper led by Piero Anversa, the last author of the Circulation paper.

Continue reading Harvard-Brigham heart researcher under investigation earns Lancet Expression of Concern

Lancet retracts Jikei Heart Study of valsartan following investigation

logo_lancetThe Lancet has retracted a study of Novartis’ blood pressure drug valsartan (Diovan) that has been subject to an investigation following the retraction of a related study earlier this year.

Continue reading Lancet retracts Jikei Heart Study of valsartan following investigation