Category: cell

“I kind of like that about science:” Harvard diabetes breakthrough muddied by two new papers

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Doug Melton

Harvard stem cell researcher Doug Melton got a lot of press last year for research on a hormone he named betatrophin, after its supposed ability to increase production of beta cells, which regulate insulin.

Now, the conclusions from that paper, which has been cited 59 times, according to Thomson Scientific’s Web of Knowledge, have been called into question by research from an independent group, as well as follow-up work from the original team.

The interest was driven by the hormone’s potential as a new treatment for diabetes. In 2013, Melton told the Harvard Gazette that betatrophin could be in clinical trials within three to five years. Here’s Kerry Grens in The Scientist: Continue reading “I kind of like that about science:” Harvard diabetes breakthrough muddied by two new papers

A PNAS expression of concern appears — and so does its revealing backstory

pnas 1113When retraction notices and expressions of concern appear, particularly those that are opaque, we try our best to find out what’s behind them, whether it’s better explanations or the steps that led to moves. Today, we have one story in which we’ve been able to learn a lot more than usual.

In April, Bas van Steensel, Wendy Bickmore, Thomas Cremer, and Kerstin Bystricky sent a letter to about 80 leading labs in nuclear organization and steroid receptor biology. It began (we’ve added some relevant links): Continue reading A PNAS expression of concern appears — and so does its revealing backstory

Cell retraction of Alzheimer’s study is second for Tufts neuroscientist

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Gizem Donmez, via Tufts

A researcher at Tufts University has retracted a paper in Cell, a year after retracting a study on a similar subject from the Journal of Biological Chemistry.

Here’s the notice for “SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10,” a 2010 paper by Tufts’ Gizem Donmez, MIT’s Leonard Guarante — of longevity research fame — and colleagues: Continue reading Cell retraction of Alzheimer’s study is second for Tufts neuroscientist

Fraud fells Alzheimer’s “made to order” neurons paper in Cell

cell414In 2011, a group of researchers at Columbia University reported in Cell that they had been able to convert skin cells from patients with Alzheimer’s disease into functioning neurons — a finding that raised the exciting prospect of “made to order” brain cells for patients with the degenerative disease. As one researcher not involved with the study, led by Asa Abeliovich, put it:

“[This is] simply a remarkable and complete piece of work which will now set a standard for stem cell work in neurological disease. The standard of the characterization of the neuronal cultures is very high,” John Hardy at University College London, U.K., wrote to [Alzforum]. He was not involved in the work but is taking a similar approach in his own lab.

According to the abstract of “Directed Conversion of Alzheimer’s Disease Patient Skin Fibroblasts into Functional Neurons:”

Continue reading Fraud fells Alzheimer’s “made to order” neurons paper in Cell

“I am deeply saddened and disturbed:” Co-author of retracted Nature paper reveals how problems came to light

Ben Scheres
Ben Scheres

On Wednesday, we reported on a Nature retraction of a paper whose corresponding author had also had a Cell paper retracted, and had been found to have committed a “violation of academic integrity” by Utrecht University. Today, we present the back story of how those retractions came to be, from another co-author of both papers, Ben Scheres, of Wageningen University: Continue reading “I am deeply saddened and disturbed:” Co-author of retracted Nature paper reveals how problems came to light

Utrecht University finds “violation of academic integrity” by former researcher

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Pankaj Dhonukshe

We have an update on the case of Pankaj Dhonukshe, a scientist about whom we reported in November. Utrecht University has found that Dhonukshe, a former researcher at the Dutch university, committed “a violation of academic integrity” in work that led to a number of papers, including one published in Nature and once since retracted from Cell.

Here’s the university’s statement: Continue reading Utrecht University finds “violation of academic integrity” by former researcher

Cell update: Co-corresponding author let go from Belgian university; retraction notice language changed

cell november 2013We’ve learned more about the circumstances behind a Cell retraction that we covered last week.

First, one of the two corresponding authors left the institution where he most recently worked. Belgium’s VIB Ghent told us that Pankaj Dhonukshe was no longer employed there and said: Continue reading Cell update: Co-corresponding author let go from Belgian university; retraction notice language changed

Authors retract Cell paper amid ongoing investigation

cell november 2013The authors of a 2012 paper in Cell have retracted it after discovering “serious issues with several figures.”

Here’s the notice for “A PLETHORA-Auxin Transcription Module Controls Cell Division Plane Rotation through MAP65 and CLASP:” Continue reading Authors retract Cell paper amid ongoing investigation

Nature yanks controversial genetics paper whose co-author was found dead in lab in 2012

naturecover1113Nature has retracted a controversial 2012 paper by a group from Johns Hopkins University which has been the subject of a protracted public dispute.

The article, “Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK,” came from the lab of Jef Boeke,  a celebrated biochemist. But a former lab member, Daniel Yuan, who was fired by Hopkins in late 2011 after 10 years at the institution, had repeatedly raised questions about the validity of the findings. Those concerns eventually made their way into the Washington Post, prompting this response from the university. Continue reading Nature yanks controversial genetics paper whose co-author was found dead in lab in 2012

Cell reviewing allegations of image reuse in human embryonic stem cell cloning paper

cell cloningCell is looking into whether the authors of a widely hailed study published last week claiming to have turned human skin cells into embryonic stem cells manipulated images inappropriately, Retraction Watch has learned.

The potential image problems came to light on PubPeer, a site designed to allow for post-publication peer review. A commenter, identified as Peer1, identified “several examples of image reuse which might be of interest to PubPeer members and readers:” Continue reading Cell reviewing allegations of image reuse in human embryonic stem cell cloning paper