Category: by institution

Stem cell researchers sue Harvard, claiming faulty investigation lost them job offers

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Piero Anversa

Piero Anversa, a stem cell researcher at the Brigham & Women’s Hospital, and a colleague, Annarosa Leri, have sued Harvard over an investigation into their work that they claim has cost them millions in a forfeited sale of their company, and job offers.

The team has had a paper in Circulation retracted, and a paper in The Lancet subject to an expression of concern.

In the suit, first reported by the Boston Business Journal and the Boston Globe, Anversa and Leri blame a co-author for the issues in the papers, and claim that their Continue reading Stem cell researchers sue Harvard, claiming faulty investigation lost them job offers

New method sinks newish paper…or does it?

cover_2009_BB_viz_biomassThe timing on a recent retraction of a paper from Biotechnology and Bioengineering makes it a bit difficult to figure out what happened, but here’s a try.

An article first published online May 16th by a group of researchers at Brown University was retracted on June 1st, apparently because a new and better method for analyzing the data was developed…at some point.

The timeline is not exactly clear from the retraction, though we’ve reached out to the author and publisher and will update with any new information.

Here’s the (paywalled) notice for “High-level production of 3-hydroxypropionatein Escherichia coli and Saccharomyces cerevisiae by introducing part of the 3-hydroxypropionate/4-hydroxybutyrate cycle from Metallosphaera sedula”:

Continue reading New method sinks newish paper…or does it?

Harvard stem cell scientist Vacanti taking leave in wake of STAP retractions

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Charles Vacanti, by Diemut Strebe via BWH

Charles Vacanti, a Harvard anesthesiologist and stem cell pioneer whose name appeared on both retracted STAP stem cell papers, is giving up his post as chair of anesthesiology at Brigham and Women’s Hospital, and taking a year-long sabbatical.

According to the Knoepfler Lab Stem Cell Blog, which as become a must-read for anyone interested in the STAP saga, Vacanti — the corresponding author, with Haruko Obokata, on one of the Nature articles, and a co-author on the other — told colleagues in an email: Continue reading Harvard stem cell scientist Vacanti taking leave in wake of STAP retractions

Authors retract highly cited XMRV-prostate cancer link paper from PNAS

pnas 1113Retraction Watch readers may recall that nearly two years ago, an editor at PLOS declared the scientific story of a link between XMRV, aka xenotropic murine leukemia-related virus, and prostate cancer over, saying that a retraction from PLOS Pathogens was the “final chapter.” (That retraction led to an apology from the journal about how it was handled.)

Perhaps, however, there is an epilogue. This week, a group of authors who published a highly cited 2009 study in the Proceedings of the National Academy of Sciences (PNAS) making the same link retracted it. Here’s the notice, signed by all five authors: Continue reading Authors retract highly cited XMRV-prostate cancer link paper from PNAS

Mystery box sinks immunology paper

Screen Shot 2014-06-30 at 12.30.32 PMBiochemical Journal has pulled a 2006 paper for an undisclosed “background subtraction box” in an image – which, if you take a not-particularly-close look at the figure to the right, means somebody added a black rectangle over the control lane.

Here’s the notice: for “Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4a transcriptional activity”: Continue reading Mystery box sinks immunology paper

Alleged Medicare cheat loses paper for data mix-up

A Boston doctor indicted on charges of Medicare fraud in 2007 has had a paper relating to the case retracted this month.

Abdul Razzaque Ahmed was considered something of a miracle worker by his patients, treating two rare and disfiguring skin conditions called pemphigoid and pemphigus vulgaris. He used more powerful medicines than the typical course of treatment, including a drug normally used to treat cancer.

The initial indictment stated that Ahmed mixed blood samples to falsely show a “dual diagnosis” of both diseases, and prove to Medicare that they required the more rigorous (and expensive) treatment. It also alleged that he profited massively from the government pay-outs. He was convicted of obstruction in 2007; the other charges were dropped when he agreed to forfeit assets worth $2.9 million.

Now, a 2001 paper by Ahmed, which claimed fifteen patients had a dual diagnosis, has been retracted because the samples were all mixed. Here is the retraction notice from Clinical Immunology: Continue reading Alleged Medicare cheat loses paper for data mix-up

Braggadacio, information control, and fear: Life inside a Brigham stem cell lab under investigation

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Piero Anversa

The following post was written by a former research fellow in the lab of Piero Anversa to whom we’ve promised confidentiality. Anversa has previously told us that he cannot comment because of an ongoing investigation.

Regular readers of Retraction Watch will note the recent news regarding the work conducted in the laboratory of Piero Anversa at Brigham and Women’s Hospital, a Harvard Medical School affiliate. In the early 2000s, his laboratory published a series of papers regarding the regenerative qualities of bone marrow-derived and cardiac-resident “stem cells.”

Those initial findings, as well as the research conducted since those early studies, have always been surrounded by controversy, as many have been unsuccessful in efforts to replicate their results. Controversy among competitors is not uncommon in our profession, but this particular one has blossomed into a formal investigation of their findings, and has, to date, led to the retraction of one paper and an expression of concern about another. Continue reading Braggadacio, information control, and fear: Life inside a Brigham stem cell lab under investigation

“Misrepresentation,” “reckless disregard for basic scientific standards”: Hauser report reveals details of misconduct

Harvard-logo_7Courtesy of a Freedom of Information Act request, The Boston Globe has a very good piece detailing what investigators found had actually happened in the Marc Hauser lab before the former Harvard psychology researcher resigned in 2011 and was found guilty of misconduct by the Office of Research Integrity (ORI) in 2012.

The Globe requested the 2010 report Harvard sent the ORI. Here’s a summary:

The 85-page report details instances in which Hauser changed data so that it would show a desired effect. It shows that he more than once rebuffed or downplayed questions and concerns from people in his laboratory about how a result was obtained. The report also describes “a disturbing pattern of misrepresentation of results and shading of truth” and a “reckless disregard for basic scientific standards.”

The Globe quotes key passages from the report: Continue reading “Misrepresentation,” “reckless disregard for basic scientific standards”: Hauser report reveals details of misconduct

Serial fakery: Researcher found to have committed misconduct at Harvard and Oxford

harvardA former Harvard postdoc who was found guilty of faking data at Oxford as a student did the same thing at Harvard, according to the Office of Research Integrity (ORI).

We first wrote about Helen Freeman in February, when we covered a retraction in Cell Metabolism that said the UK’s Medical Research Council had found that she committed misconduct while working as a student at Oxford. Today, a Federal Register notice from the ORI reports that Freeman faked images in a manuscript submitted to Nature while she was working on federally funded grants at Harvard Medical School and Beth Israel Deaconess Medical Center.

From the ORI’s report: Continue reading Serial fakery: Researcher found to have committed misconduct at Harvard and Oxford

NIH/Harvard team loses aging study to manipulated data

agecoverAge has retracted a 2012 article by a group of scientists from the National Institutes of Health and Brigham and Women’s Hospital in Boston after an NIH inquiry turned up evidence of data manipulation in the work.

The article, “Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver,” came from the lab of Stanley Rapoport, chief of the brain physiology and metabolism section of the National Institute on Aging.

As the abstract explained: Continue reading NIH/Harvard team loses aging study to manipulated data