Category: germany retractions

Retractions follow revelations of misconduct by diabetes biotech

diabetes careSeveral months after a drug company cancelled development of a potential diabetes cure because it found evidence that a biotech they had recently acquired had committed misconduct in studies of the drug, two retractions of relevant studies have appeared.

The research involves DiaPep277, which, as Josh Levy explained here in September, “would cause the immune system to stop attacking beta cells,” the cells in the pancreas that produce insulin. But Hyperion Therapeutics, which had acquired DiaPep277 developer Andromeda Biotech in June, announced in September that it had

uncovered evidence that certain employees of Andromeda Biotech, Ltd., which Hyperion acquired in June 2014, engaged in serious misconduct, including collusion with a third-party biostatistics firm in Israel to improperly receive un-blinded DIA-AID 1 trial data and to use such data in order to manipulate the analyses to obtain a favorable result.

The retractions are both of papers published in Diabetes Care in May 2014. Here’s the notice for “Treatment of Recent-Onset Type 1 Diabetic Patients With DiaPep277: Results of a Double-Blind, Placebo-Controlled, Randomized Phase 3 Trial:” Continue reading Retractions follow revelations of misconduct by diabetes biotech

Stem cell researcher retracts neuron paper for “image aberrations”

embo journalJens Christian Schwamborn, a stem cell researcher at the University of Luxembourg, is retracting a 2007 paper on how to grow brain cells.

The paper, “Ubiquitination of the GTPase Rap1B by the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity,” was published while Schwamborn was at Westfälische Wilhelms‐Universität Münster in Germany. An anonymous critic had sent questions about the study to Germany’s DFG in the middle of last year, and later to Paul Brookes, who posted them on PubMed Commons.

Those criticisms match the problems listed in the detailed notice: Continue reading Stem cell researcher retracts neuron paper for “image aberrations”

Boldt’s data were fake in 1996 paper

Ludwigshafen Hospital, via Wikimedia http://commons.wikimedia.org/wiki/File:Klinikum_Ludwigshafen_Nordseite.jpg
Ludwigshafen Hospital, via Wikimedia http://commons.wikimedia.org/wiki/File:Klinikum_Ludwigshafen_Nordseite.jpg

Update, 4 p.m. EST, 10/29/14: As a commenter points out, we didn’t quite get this one right. The Boldt paper that has been retracted was not previously retracted for lack of IRB approval. Rather, it was a heretofore unretracted article, from 1996, which German investigators have determined contained faked data. We’ve made edits below using strikethroughs, and have changed the headline to better reflect the content. We apologize for the errors.

We’ve commented before on the fact that we’ve noticed there’s often more to retractions whose stated reason is lack of institutional review board (IRB) approval. We can understand editors’ inclination to act as quickly as possible to issue a retraction, the scientific publishing equivalent of jailing Al Capone for tax evasion. But we appreciate it even more when said editors return to the scene of the crime, as it were, when new important details come out.

Case in point: Anesthesia & Analgesia has amended its retraction of a 2009 1996 study by Joachim Boldt — who with nearly 90 retractions once held the record in that department — based on findings that the data in that paper were fabricated.

The article was titled “Cardiopulmonary bypass priming using a high dose of a balanced hydroxyethyl starch versus an albumin-based priming strategy,” “The effects of albumin versus hydroxyethyl starch solution on cardiorespiratory and circulatory variables in critically ill patient.”  had previously been retracted because Boldt had failed to obtain adequate ethics approval for the research. But now comes this, According to the retraction notice from editor in chief Steven Shafer: Continue reading Boldt’s data were fake in 1996 paper

Quantum physics paper pulled for “serious theoretical errors,” notice accidentally paywalled

physicalreviewlettersA paper on photonic quantum walks has been retracted over a theoretical disagreement.

The notice is also paywalled, which the editorial director has assured us is a mistake that is being corrected.

We sent the COPE guidelines on retraction to the American Physical Society, which publishes Physical Review Letters. Editorial director Dan Kulp told us the paywall was the unintentional consequence of a web redesign, and that they are in the process of restoring public access to “all Errata-types, including Retractions.”

Here’s the rest of his statement: Continue reading Quantum physics paper pulled for “serious theoretical errors,” notice accidentally paywalled

After 16 retractions, management professor Lichtenthaler resigns post

Ulrich Lichtenthaler
Ulrich Lichtenthaler

Ulrich Lichtenthaler, a management professor at the University of Mannheim who has had to retract 16 papers for data irregularities, has resigned his faculty position.

According to a terse release from the university (translated from German): Continue reading After 16 retractions, management professor Lichtenthaler resigns post

Two-timing sinks papers on ships in journal shaken by major scandal

jvcWhen we heard about this retraction, we were forced to ask: Are there any articles left in Journal of Vibration & Control?

The publication was forced to retract 60 papers by the same author in July, after he was caught exploiting a technological loophole to review his own papers.

Now, papers on loading cargo ships has been felled by a much less tech-savvy method: Two authors submitted a paper to both Mathematical and Computer Modelling of Dynamical Systems and the Journal of Vibration & Control, both of which accepted and published the paper.

The authors, Yousef M. Al-Sweiti and Dirk Soeffker, have now lost three papers in total. Here’s the joint notice from SAGE and Taylor & Francis (we’ve added links to relevant retractions): Continue reading Two-timing sinks papers on ships in journal shaken by major scandal

Authors retract PNAS brain genetics paper for statistical issues

pnas 1113The authors of a paper on brain genetics published online in June in the Proceedings of the National Academy of Sciences (PNAS) are retracting it for “a potential confound relating to statistical inference.”

Here’s the notice for “Identification of gene ontologies linked to prefrontal–hippocampal functional coupling in the human brain:” Continue reading Authors retract PNAS brain genetics paper for statistical issues

Another Nature stem cell paper is retracted

nature 73014Another stem cell paper has been retracted from Nature, this one a highly cited 2008 study that had already been the subject of what the journal’s news section called a “furore” in 2010.

According to that 2010 news story:

The researchers behind the original work1, led by Thomas Skutella of the University of Tübingen, reported using cells from adult human testes to create pluripotent stem cells with similar properties to embryonic stem cells.

But a 2010 Brief Communication Arising called those findings into question. And now, the authors have retracted the paper. Here’s the notice for “Generation of pluripotent stem cells from adult human testis:” Continue reading Another Nature stem cell paper is retracted

Cardiology researcher who admitted to fraud earns four-year funding ban

dfg_logoA researcher who admitted in 2012 to “intentional and systematic manipulation” of data and had two papers retracted has been banned from funding by the German Research Foundation (DFG).

Dennis Rottländer, who will also be returning prize money he was awarded for the research, worked in Uta C. Hoppe’s lab at the University of Cologne. Hoppe, now at University Hospital Salzburg, remains under investigation, according to a statement from the DFG.

Excerpt: Continue reading Cardiology researcher who admitted to fraud earns four-year funding ban

PLoS ONE issues expression of concern when company won’t share bacterial strain

plosoneThe editors of PLoS ONE have issued an expression of concern for a 2014 article on a form of nitrogen-fixing bacteria called Bacillus pumilus.

The reason: The company that provided the strain of microbe used in the research won’t let other researchers look at the organism.

The article is titled “Bacillus pumilus Reveals a Remarkably High Resistance to Hydrogen Peroxide Provoked Oxidative Stress,” and it came from a group led by Stefan Handtke, of the University of Greifswald, in Germany.

Here’s the notice: Continue reading PLoS ONE issues expression of concern when company won’t share bacterial strain