The journal Cancer has issued an Expression of Concern about two lung cancer screening papers long dogged by doubt.
Last April, The Cancer Letter and The New York Times jointly published an investigation into the International Early Lung Cancer Action Program (I-ELCAP) run by Claudia Henschke and David Yankelevitz. Other researchers had already criticized the design and conclusions of that trial, but as the investigation noted, an October 2008 review of the study found that the researchers couldn’t find 90 percent of the subjects’ consent forms, an ethical no-no that jeopardizes as many as 135 papers.
Don Quixote and Sancho Panza, Madrid. Photo by Zaqarbal via Wikimedia
If Retraction Watch was actually a business, as opposed — for the moment, anyway — to a labor of love for two guys with day jobs, 2011 would have been a very good year for business.
It was a year that will probably see close to 400 retractions, including a number of high-profile ones, once the dust settles. Those high numbers caught the attention of a lot of major media outlets, from Nature to NPR to the Wall Street Journal. Science publications, including LiveScience and The Scientist, have done their own end-of-year retraction lists.
“Neither snow nor rain nor heat nor gloom of night” keeps U.S. mail carriers from delivering your letters and packages, and neither seven retractions, nor being forced to resign, nor malpractice settlements (and an ongoing case) keeps former Duke oncologist Anil Potti from publishing papers.
Science is fully retracting the Report “Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome” (1). Multiple laboratories, including those of the original authors (2), have failed to reliably detect xenotropic murine leukemia virus–related virus (XMRV) or other murine leukemia virus (MLV)–related viruses in chronic fatigue syndrome (CFS) patients. In addition, there is evidence of poor quality control in a number of specific experiments in the Report. Fig. 1, table S1, and fig. S2 have been retracted by the authors (3).
If there’s one consistent lesson of covering retractions, it’s that science doesn’t stop when researchers publish a paper. But what also seems true is that once a paper is published, lots of people — authors and editors, in particular — are often reluctant to say just what’s happened next, particularly if it casts the study or the journal in a negative light.
Some of this is understandable, given the weight given papers by tenure committees and granting agencies. Still, Retraction Watch readers will not be surprised to know we’d like that to change, so when Nature asked us to contribute an end-of-the-year commentary, we decided to focus on post-publication peer review. In our piece, which appears this week, titled “The paper is not sacred,” we argue: Continue reading Stop fetishizing the scientific paper: Our invited Comment in Nature
By now, Retraction Watch readers are familiar with papers that are withdrawn because of faked data. Those cases may involve pressure cooker environments, bad seeds, or both, but they’re usually intentional. But what if a researcher fabricated findings without even knowing it?