Author: Adam Marcus

Tangled leads: Cardiac study retraction reveals a company’s stopped trials, and lots of questions

A retraction in an obscure journal. An equally obscure retraction notice. An Israeli company with no web presence. Conflicts of interest involving authors and editors.

That’s what we’ve uncovered so far after noticing the other day that the American Journal of the Medical Sciences (AJMS) had retracted a May 2010 article by a group of Israeli heart doctors led by Arthur Shiyovich, of Barzilai Medical Center in Ashkelon.

The paper described promising results in a study of a new test for diagnosing coronary artery disease at the bedside by measuring aspects of a patient’s pulse at the fingertip.

As AJMS editor David Ploth told us, the approach had seemed “kind of innovative” to him, so he’d accepted the manuscript: “It seemed like it might have some applicability.”

Ploth was therefore surprised sometime later to receive a letter from the authors requesting that the journal retract their paper. According to the journal: Continue reading Tangled leads: Cardiac study retraction reveals a company’s stopped trials, and lots of questions

Unglaublich! Boldt investigation may lead to more than 90 retractions

Ludwigshafen Hospital, via Wikimedia http://commons.wikimedia.org/wiki/File:Klinikum_Ludwigshafen_Nordseite.jpg

Self-plagiarism alert: A very similar version of this post is being published online in Anesthesiology News, where one of us (AM) is managing editor.

Unglaublich is the German word for unbelievable, and it’s an apt description for the latest development in the case of Joachim Boldt.

Boldt, a prominent German anesthesiologist, has been at the center of a research and publishing investigation since last October, when the journal Anesthesia & Analgesia retracted a 2009 article of his over concerns of data manipulation. This morning, the German medical board overseeing the case, the Landesärztekammer Rheinland-Pfalz (LÄK-RLP),  released its findings — and they are truly stunning.

According to LAK, somewhere in the neighborhood of 90 of Boldt’s published articles might require retraction because the investigator failed to obtain approval from an institutional review board to conduct the research.

We don’t read German. But, fortunately, the LÄK-RLP announcement was accompanied by a joint letter posted to the websites of 11 major anesthesia journals. We do read English, and here’s what that letter says: Continue reading Unglaublich! Boldt investigation may lead to more than 90 retractions

Retractions arrive in case of Edward Erin, British allergist who tried to poison mistress

Good people can make bad researchers, but can bad people make good science?

We’re agnostic on the question, but anyone who thinks the answer is no need look only as far as Edward Erin for validation of that view. An allergy expert in the U.K., Erin was convicted in 2009 of attempting to poison a mistress in an effort to induce an abortion.

Erin, who is now serving a six-year prison sentence for his crime, was evidently something of a libertine. The Mirror described him as a

serial adulterer who revelled in the sexual freedom of the ‘open relationship’ his wife allowed him.

According to the Mirror: Continue reading Retractions arrive in case of Edward Erin, British allergist who tried to poison mistress

We wrote what? Breast cancer paper falls to rogue author

Something was fishy at China Normal University. According to the journal Anti-Cancer Drugs, a 2010 paper by researchers at the Beijing school — “3,30′-Diindolylmethane negatively regulates Cdc25A and induces a G2/M arrest by modulation of microRNA21 in human breast cancer cells” — turned out to have suffered from an unfortunate anomaly. According to the retraction notice: Continue reading We wrote what? Breast cancer paper falls to rogue author

Georgia (well, the Medical College there, anyway) on our minds for a mysterious retraction

We’re watching a case which appears to involve more than meets the eye.

Molecular Endocrinology has retracted a 2010 study by researchers at the Medical College of Georgia. According to the Spartan retraction notice (we added a link): Continue reading Georgia (well, the Medical College there, anyway) on our minds for a mysterious retraction

And that’s 14: More (and more) Mori retractions, as Japanese cancer journal pulls three papers

Naoki Mori

The steady drip-drip-dripping sound you hear from the cancer literature these days comes from the stream of retractions involving studies by Naoki Mori, the now jobless scientist whose work on cancer viruses appears to be evaporating before our eyes.

Cancer Science, which used to be called the Japanese Journal of Cancer Research,  has retracted three more of Mori’s papers, each of which, according to the journal, contained multiple unreliable images. That brings the tally of retractions involving Mori’s articles to 14 by our count, an impressive number by any measure. Mori has more than 50 papers to his name, however, so it’s possible that the number of retractions will grow.

Here are the latest retractions: Continue reading And that’s 14: More (and more) Mori retractions, as Japanese cancer journal pulls three papers

Inability to reproduce Dutch grad student’s data prompts two retractions from the cancer lit

We are watching an intriguing case out of the Netherlands, involving a young researcher whose dubious results have led to the retraction of a pair of papers.

The retracted articles, which appeared in 2008 in Cancer Research and the British Journal of Cancer, come from the lab of the prominent Dutch scientist Ed Roos, of the Netherlands Cancer Institute in Amsterdam. Both papers addressed the actions of certain chemokine receptors — molecules on cell surfaces that interact with blood proteins involved in the immune response — on the behavior of tumor cells.

The first author on each paper was Joost Meijer, at the time a graduate student in Roos’ shop.

The retraction notices contain essentially the same information, although in the case of the BJC article — “Effect of the chemokine receptor CXCR7 on proliferation of carcinoma cells in vitro and in vivo” — the letter is quite personal. Dated Jan. 4, 2011, it reads: Continue reading Inability to reproduce Dutch grad student’s data prompts two retractions from the cancer lit

Cracking the Mori case: A reviewer describes how manipulated images came to light

Naoki Mori

We’ve had two questions since learning of the fraud case involving Naoki Mori: Who discovered the manipulations? And how?

We now have answers. We recently received an e-mail from a researcher who specializes in Mori’s field — cancer viruses — and who claims to have been a reviewer of a paper he submitted early last year to a journal in his field. (We’re obscuring some details to maintain our source’s anonymity.)

During what turned out to be a “painful” review of the manuscript: Continue reading Cracking the Mori case: A reviewer describes how manipulated images came to light

Lab gadfly PETA pressures AACR, gets retraction from sanctioned scientist

People for the Ethical Treatment of Animals (PETA) may not be on most scientists’ list of Facebook friends, but we’re grateful to them for a hat tip. Several days ago, we were approached by Justin Goodman, associate director of PETA’s laboratory investigations department, with a new twist on an old story.

First, a little history: In September 2009, the Office of Research Integrity sanctioned an ex-Vanderbilt cancer researcher named Nagendra S. Ningaraj. According to the agency, Ningaraj Continue reading Lab gadfly PETA pressures AACR, gets retraction from sanctioned scientist

Mori, now up to 11 retractions, was dismissed in August over fraud matter

We’ve been honored by all the attention Retraction Watch has been getting for breaking the story of Naoki Mori—the Japanese virologist who recently received a 10-year publishing ban from the American Society of Microbiology over concerns that he manipulated his images. Mori’s retraction count is now up to 11, we’ve been able to report with help from loyal Retraction Watch tipsters.

So in that spirit, we have to give credit to Dennis Normile at ScienceInsider, for advancing the story a bit. As Normile reports today, Nori lost his job at University of the Ryukyus in August and has resorted to “legal mediation” to get it back. (We’ve been unsuccessful in reaching Mori.) Continue reading Mori, now up to 11 retractions, was dismissed in August over fraud matter