Retraction Watch

Tracking retractions as a window into the scientific process

Archive for the ‘cell death and differentiation’ Category

Journal retracts paper due to image mismatch; one co-author alleges fraud

with 18 comments

Researchers have retracted a biology paper that included an image mismatch — despite the fact that, as they claim, another image in the same paper confirms the original findings.

The authors say they plan to resubmit the paper with the corrected figure panel.

The second to last author — Carlo Croce, chair of the department of cancer biology and genetics at The Ohio State University — told us he believes there’s more to the retraction than what the notice says. Specifically, he said that the paper includes an image from a previous paper by the same authors, which he called “fraud.”

Here’s the latest retraction notice, published in Cell Death and Differentiation:

Read the rest of this entry »

Authors retract 2016 cancer study when data don’t align with figures

with 2 comments

cell-death-and-differentiationResearchers have retracted a 2016 cancer study, citing discrepancies between the data and images presented in the paper. 

Although the retraction notice itself contains relatively little information, we’ve obtained a letter from the last author — Jun-Li Luo of The Scripps Research Institute in Jupiter, Florida — to the editor-in-chief of Cell Death and Differentiation that says a bit more. 

According to the letter, after receiving the anonymous email, Luo conducted an investigation, contacting co-authors who contributed each of the figures in question. Although Luo writes that he has no reason to suspect fraud, the researchers were not able to provide some of the original data.

PubPeer commenters have questioned figures 1, 3, 4, 5, 6 and 7 in the study, “IKKα-mediated biogenesis of miR-196a through interaction with Drosha regulates the sensitivity of cancer cells to radiotherapy.”

In the letter, Luo tells Gerry Melino, co-editor-in-chief of the journal from the University of Leicester, UK, that figures 3D and 3E were provided by the study’s first author, Xing Fang, adding: Read the rest of this entry »

Figure duplication kills cell death paper

with 16 comments

cdd_cimageA pair of researchers at the University of Maryland have retracted a paper in Cell Death & Differentiation after it became clear that one of the figures had been duplicated from an earlier paper.

Here’s the notice, dated December 13, 2013, for “INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis,” by Suryakant Niture and Anil Jaiswal: Read the rest of this entry »

Should scientific misconduct be handled by the police? It’s fraud week at Nature and Nature Medicine

with 33 comments

naturemed1213It’s really hard to get papers retracted, police might be best-equipped to handle scientific misconduct investigations, and there’s finally software that will identify likely image manipulation.

Those are three highlights from a number of pieces that have appeared in Nature and Nature Medicine in the past few weeks. Not surprisingly, there are common threads, so join us as we follow the bouncing ball. Read the rest of this entry »

ALS paper retracted for figure problems

with 11 comments

cd&dA group of researchers in Ireland has retracted their 2013 article on a possible new method for treating amyotrophic lateral sclerosis — ALS, also commonly called Lou Gehrig’s disease — after identifying errors in several images in the paper.

The article, “Acidotoxicity and acid-sensing ion channels contribute to motoneuron degeneration,” was published online in Cell Death & Differentiation (and appeared in the April 1 print issue, although we think that was a coincidence…). Read the rest of this entry »

Two retractions for scientist whose work is “not fully supported by the available laboratory records”

with 12 comments

SK Manna

SK Manna

The head of immunology at India’s Centre for DNA Fingerprinting and Diagnostics, Sunil Kumar Manna, has retracted two papers for image problems.

Here’s the notice from Cell Death and Differentiation for “Inhibition of RelA phosphorylation sensitizes apoptosis in constitutive NF-kappaB-expressing and chemoresistant cells:” Read the rest of this entry »

University College London mitochondrial biologist resigns after three retractions for image fraud

with 10 comments

Courtesy Nature Publishing Group

A biologist at University College London (UCL) has resigned his post and taken responsibility for “inappropriate figures manipulations” in three now-retracted papers.

Assegid Garedew, formerly a senior research investigator in Salvador Moncada‘s group, stepped down earlier this summer in the midst of an investigation that should be completed soon, Moncada tells Retraction Watch.

The three retraction notices for papers by Garedew and colleagues are all similar.

From Cell Metabolism: “Mitochondrial Dynamics, Biogenesis, and Function Are Coordinated with the Cell Cycle by APC/CCDH1“, cited once, according to Thomson Scientific’s Web of Knowledge: Read the rest of this entry »