Category: jbc retractions

Researcher in Ireland loses two 13-year old studies

journal-of-biological-chemistryThe Journal of Biological Chemistry (JBC) has retracted two 2003 studies after concluding that figures in the papers had been duplicated, and portions of some figures in one paper “did not accurately represent the results of the experimental conditions.”

The two newly retracted papers have the same last author — Therese Kinsella, a biochemist at the University College Dublin (UCD), who told us the data have been upheld by subsequent research, but that she supports the retractions, which are now part of a UCD investigation.

The retractions will bring up some familiar names: The first author on one of the papers is Sinéad Miggin from Maynooth University in the Republic of Ireland; in 2014, Miggin logged two retractions in the JBC, which triggered an investigation into co-author Aisha Qasim Butt. Last year, Maynooth University revoked Butt’s PhD after she admitted to “falsification and misrepresentation” of data in both studies as well as her PhD thesis. At the time, Miggin and two other researchers were fully exonerated by Maynooth University from “any wrongdoing.”

Butt, however, is not an author of either of the newly retracted papers. Although Butt’s LinkedIn page still lists her as a postdoctoral researcher at UCD, a spokesperson from the institution told us she is no longer based there.

We don’t often see such old papers retracted. Kaoru Sakabe, Manager of Publishing Issues at the American Society for Biochemistry and Molecular Biology, which publishes JBC, told us how this decision came about: Continue reading Researcher in Ireland loses two 13-year old studies

Correction cites “unreliable” data in paper by researchers at center of Duke lawsuit

Journal of Biological ChemistryA researcher charged with embezzlement — and now the subject of a multi-million dollar lawsuit — has earned another correction, again citing “unreliable” data.

But this doesn’t appear to be a run-of-the-mill correction notice.

Firstly, it affects a paper co-authored by Erin Potts-Kant and William Foster, former Duke employees now being sued (along with Duke) for including fraudulent data in $200 million worth of federal grants. Secondly, the notice in the Journal of Biological Chemistry is four paragraphs long, and includes six figures — it would normally be considered a “mega-correction.” But lastly, even though the notice is labeled a “correction,” it’s not immediately apparent which aspects of the paper are being changed.

Here are some excerpts from the newest notice: Continue reading Correction cites “unreliable” data in paper by researchers at center of Duke lawsuit

Spanish lab admits to image manipulation, retracts one paper, corrects another

JBCA group has retracted one paper and corrected another in the Journal of Biological Chemistry (JBC) for image manipulations.

Last author José G. Castaño told us the manipulation occurred at the Universidad Autónoma de Madrid, where he and one other co-author are based. He declined to name who was responsible.

Here’s the retraction notice for “Cytomegalovirus promoter up-regulation is the major cause of increased protein levels of unstable reporter proteins after treatment of living cells with proteasome inhibitors:”

Continue reading Spanish lab admits to image manipulation, retracts one paper, corrects another

Retraction appears for group whose former member was sanctioned by ORI

Journal of Biological ChemistryResearchers whose former colleague was recently reprimanded by the U.S. Office of Research Integrity (ORI) have retracted a biology paper for duplication.

The retraction includes some familiar names: The last author Steven Grant, senior author of the newly retracted study, is also the last author of 11 papers flagged in a report by the ORI in December, 2015. That report focused on Girija Dasmahapatra, a co-author of the 11 studies who was also based at at Virginia Commonwealth University (VCU). Dasmahapatra left VCU in 2015, and is not listed on the latest retraction.

The retracted paper, published in The Journal of Biological Chemistry (JBC), was also co-authored by Paul Dent, a biochemist at the VCU, who we mentioned last year when he offered to retract another paper in Molecular Pharmacology after concerns arose on PubPeer. The journal has instead issued a lengthy correction (what we call a “mega-correction”).

A VCU spokesperson told us:
Continue reading Retraction appears for group whose former member was sanctioned by ORI

Seven retractions for prominent cancer researcher brings total to 18

Bharat Aggarwal
Bharat Aggarwal

A cancer researcher has earned seven more retractions following an investigation into his work by his former employer, MD Anderson Cancer Center in Texas, bringing his total to 18 retractions.

Bharat Aggarwal‘s name will be familiar to some readers, as he has threatened to sue Retraction Watch for reporting on his case.

All of the new retraction notices, issued by The Journal of Biological Chemistry (JBC), stem from image-related issues. The now-retired Aggarwal has seven papers that have each been cited at least 1,000 times, and in 2015, he was on Thomson Reuters Web of Science’s list of The World’s Most Influential Scientific Minds. With these new notices, he also has made it to our leaderboard of individual researchers who’ve racked up the most retractions.

An MD Anderson spokesperson sent us this statement: Continue reading Seven retractions for prominent cancer researcher brings total to 18

Harvard researcher’s PhD revoked, former group earns three more retractions

Journal of Biological ChemistryA research fellow at Harvard has lost his PhD from a university in Singapore after being found guilty of falsifying data, and his former group leader’s contract has been terminated by his institution.

But that’s not the whole story. This tangled mess involves not only the Harvard researcher, Sudarsanareddy Lokireddy, and his former boss, Ravi Kambadur at the Nanyang Technological University (NTU) in Singapore, but an as-yet unnamed colleague of theirs who, we’re told, has admitted making up data in three papers, on which Lokireddy and Kambadur are co-authors. Bear with us as we walk you through this tale.

Two of those papers have been retracted by The Journal of Biological Chemistry (JBC); one in Molecular Endocrinology has yet to be pulled. Kambadur, who held joint appointments at the NTU and the Agency for Science, Research and Technology (A*STAR) in Singapore, has now had his contract terminated at both institutions.  Continue reading Harvard researcher’s PhD revoked, former group earns three more retractions

Second retraction for researcher who faked 70+ experiments

Journal of Biological ChemistryTwo researchers found to have faked data by the U.S. Office of Research Integrity (ORI) have lost a paper that they co-authored.

According to the ORI report issued on May 25, Ricky Malhotra, one of the researchers in question, admitted to fabricating 74 experiments, and falsifying well over 100 Western blots while at the Universities of Michigan (UM) and Chicago (UC). One week later, the ORI issued additional findings about Karen D’Souza, a colleague of Malhotra’s at the UC, concluding that she had also falsified some data.

Both researchers agreed to the retraction of a 2010 paper published in The Journal of Biological Chemistry (JBC), the reports note.

Here’s the retraction notice, issued on July 1: Continue reading Second retraction for researcher who faked 70+ experiments

Diabetes researcher logged 1 retraction, 3 correx, after PubPeer comments

Kathrin Maelder
Kathrin Maedler

A journal has retracted a paper by a leading diabetes researcher — who has also issued three corrections — after questions about her research were raised on PubPeer.

Kathrin Maedler — who works at the University of Bremen in Germany — corrected another paper in 2014. All of the notices are dated from 2015, and all describe issues with figures.

The ongoing comments have led Maedler to carefully look through her original data, according to a statement she emailed us: Continue reading Diabetes researcher logged 1 retraction, 3 correx, after PubPeer comments

1st retraction for biologist who doctored 40+ images, received funding ban

JBC CoverThe Journal of Biological Chemistry has retracted a paper that was one of eight flagged in a recent investigation by the Office of Research Integrity (ORI). The investigation — which concluded that a biologist had falsified or fabricated more than 40 images — resulted in a five-year funding ban. 

In May, the ORI announced that John Pastorino, an erstwhile cell biologist at Rowan University in New Jersey, falsified and/or fabricated eight of his published papers (and one unpublished one). Nataly Shulga is a co-author on all eight papers. Six of those eight papers had already received expressions of concern (EOC).

The first retraction to result from the investigation is one of the two published papers that had not been tagged by an EOC. Here’s the retraction notice: Continue reading 1st retraction for biologist who doctored 40+ images, received funding ban

Authors reused images in three papers, concludes journal probe

JBCBiologists are retracting three papers after the journal concluded they contain reused images, designed to represent different experiments. The authors stand by the conclusions, some of which they say have been “extensively validated.”

The Journal of Biological Chemistry used image analysis software to evaluate the images, first published at least a decade ago. Unfortunately, the raw data behind the problematic images were not available. The authors have also corrected a fourth paper in another journal, and wrote on PubPeer that they are working with journals to address concerns in three more.

The papers share two authors: Mireia Duñach at the Autonomous University of Barcelona, and Antonio García de Herreros at the Institut Hospital del Mar d’Investigacions Mèdiques. A representative of the Institut Hospital del Mar d’Investigacions Mèdiques told us it is looking into Garcia de Herreros’s work.

We’ll start with “β-Catenin N- and C-terminal tails modulate the coordinated binding of adherens junction proteins to β-catenin,” which has been cited 45 times since it was published in 2002, according to Thomson Reuters Web of Science. The retraction notice says:

Continue reading Authors reused images in three papers, concludes journal probe