Category: infectious disease

University of Minnesota swine flu researcher under investigation for alleged misconduct

goyal
Sagar Goyal, via University of Minnesota

In late December, we reported on the retraction of a 2010 research letter in Emerging Infectious Diseases looking at the genetics of swine flu.

The notice in the journal, a CDC publication, indicated that the conclusions were in error, although it didn’t really say much more:

To the Editor: We would like to retract the letter entitled “Triple Reassortant Swine Influenza A (H3N2) Virus in Waterfowl,” which was published the April 2010 issue of Emerging Infectious Diseases (1). The nucleoprotein gene sequences from the viruses reported in that letter are very closely related to those from the earliest detected triple reassortant swine influenza viruses [CY095676 A/sw/Texas/4199–2/1998(H3N2)]. Although these viruses could have acquired a swine-origin segment, the branch lengths are quite short for 9 years of evolution. Therefore, we have withdrawn these 4 isolates from GenBank and subsequently retract this letter.

As it happens, there was more to the story.

Continue reading University of Minnesota swine flu researcher under investigation for alleged misconduct

“Unreliable” findings fell TB gene study in PLOS ONE

plosoneHere’s a nice example of how science should work.

A team of Swiss microbiologists has retracted their 2012 paper in PLoS One on the genetics of the TB mycobacterium after learning that the fusion protein they thought they’d used in their study was in fact a different molecule.

Here’s the retraction notice for the article, “A β-lactamase based reporter system for ESX dependent protein translocation in mycobacteria,” which has been cited once, according to Thomson Scientific’s Web of Knowledge: Continue reading “Unreliable” findings fell TB gene study in PLOS ONE

Study finds many authors aren’t sharing data when they publish — and leads to a PLOS ONE retraction

clinical chemistryA new study in Clinical Chemistry paints an alarming picture of how often scientists deposit data that they’re supposed to — but perhaps not surprisingly, papers whose authors did submit such data scored higher on a quality scale than those whose authors didn’t deposit their data.

Ken Witwer, a pathobiologist at Hopkins, was concerned that a lot of studies involving microarray-based microRNA (miRNA) weren’t complying with Minimum Information About a Microarray Experiment (MIAME) standards supposedly required by journals. So he looked at 127 such papers published between July 2011 and April 2012 in journals including PLOS ONE, the Journal of Biological Chemistry, Blood, and Clinical Chemistry, assigning each one a quality score and checking whether the authors had followed guidelines.

What he uncovered wasn’t pretty — and has already led to a retraction. From the abstract: Continue reading Study finds many authors aren’t sharing data when they publish — and leads to a PLOS ONE retraction

Lyme disease diagnostics review retracted for plagiarism

Medical reviewA review paper published in the Serbian journal Medicinski pregled (Medical review) has been retracted for plagiarising a 2002 paper published in the Croatian Journal of Infection (or Infektološki glasnik).

The retraction note (in Serbian only) in the current issue (vol. 65, issue 11-12) of Medicinski pregled, published by the Society of Physicians of Vojvodina of the Medical Society of Serbia reads: Continue reading Lyme disease diagnostics review retracted for plagiarism

Plague paper partially retracted

iandi213coverPartial retractions — as opposed corrections or the full monty —  are unusual events in scientific publishing. But they appear to come in twos.

The journal Infection and Immunity, the work of whose editor, Ferric Fang, is much admired by this blog, has a fascinating example of the breed in its February issue.

The article in question, by a group from the University of Kentucky in Lexington led by Susan Straley, appeared online in 2007. It was titled “yadBC of Yersinia pestis, a New Virulence Determinant for Bubonic Plague,” and, as the words suggest, involved a gene marker for the virulence of plague. Or so it initially seemed.

But according to the partial retraction, the researchers are walking back one of their main claims. Consider: Continue reading Plague paper partially retracted

Paper on how swine flu might spread to birds retracted for error

eidcoverEmerging Infectious Diseases, a CDC journal, is retracting a 2010 paper about swine flu by a group of Minnesota researchers who acknowledged misinterpreting their results.

The study, a letter titled “Triple Reassortant Swine Influenza A (H3N2) Virus in Waterfowl,” claimed to shed new light on how flu viruses might jump between species: Continue reading Paper on how swine flu might spread to birds retracted for error

High school whiz kid retracts PLoS ONE herd immunity paper

Georgette speaking at the Davidson Institute’s award ceremony, Library of Congress, 2008

It’s pretty impressive to publish two peer-reviewed papers on complicated vaccination models while you’re still in high school. So it’s not surprising that Nathan Georgette, who grew up outside of Jacksonville, Florida, earned a prestigious fellowship from the Davidson Institute for Talent Development.

But perhaps even more impressive is realizing you’ve made a fundamental error in one of those studies, and retracting it while you’re still a college senior at Harvard. Continue reading High school whiz kid retracts PLoS ONE herd immunity paper

Another XMRV shoe drops: PLoS Pathogens study linking prostate cancer to virus retracted

Less than 24 hours after the publication of a study showing no link between XMRV, aka xenotropic murine leukemia-related virus, and chronic fatigue syndrome (CFS), the authors of a a study claiming a link between the virus and prostate cancer have has been retractedit. The move comes along with the publication of a new study showing that no such link exists.

Here’s the notice, from PLoS Pathogens: Continue reading Another XMRV shoe drops: PLoS Pathogens study linking prostate cancer to virus retracted

New study “puts…speculation to rest” about link between XMRV and chronic fatigue syndrome

Could this really — and finally — be the end for the alleged link between XMRV, also known as xenotropic murine leukemia-related virus, to chronic fatigue syndrome (CFS)?

The title of the press release announcing a long-awaited study of the subject in mBio is blunt: “Viruses not to blame for chronic fatigue syndrome after all.” A quote in the release from Ian Lipkin, who led the study, is even more direct: Continue reading New study “puts…speculation to rest” about link between XMRV and chronic fatigue syndrome

More shoes drop for Chinese author who made up peer reviewer addresses

Last month, we brought you the story of Guang-Zhi He of the Guiyang College of Traditional Chinese Medicine in China, an enterprising fellow who got caught faking the email addresses of potential peer reviewers. At the time, Elsevier, who published journals where He published, told us there would be several retractions other than the one we reported on.

Three of those have appeared, in the same journal, Experimental Parasitology, and saying the same thing: Continue reading More shoes drop for Chinese author who made up peer reviewer addresses